Splanchnic neuromodulation for heart conditions

Patent metadata

Field	Value
Publication number	US-2024198107-A1
Application number	US-202318389093-A
Country	US
Kind code	A1
Filing date	Nov 13, 2023
Priority date	Dec 19, 2022
Publication date	Jun 20, 2024
Grant date	—

Abstract

A therapeutic system and method are described. In one example, the system may include an implantable pulse generator configured to generate a current, a plurality of electrodes configured to apply the current to one or more splanchnic nerves of a patient, where each of the plurality of electrodes comprises at least one of an anode or a cathode, a processor, and memory. In some examples, the processor may receive sensor information describing subcutaneous nerve activity of the patient and adjust one or more parameters of the implantable pulse generator based on the subcutaneous nerve activity.

First claim

What is claimed is:

1 . A therapeutic system, comprising:
an implantable pulse generator configured to generate a current; a plurality of electrodes configured to apply the current to one or more splanchnic nerves of a patient, wherein each of the plurality of electrodes comprises at least one of an anode or a cathode; a processor; and a memory storing data for processing by the processor, the data, when processed, causes the processor to:
receive sensor information describing subcutaneous nerve activity of the patient; and
adjust one or more parameters of the implantable pulse generator based on the subcutaneous nerve activity.

2 . The system of claim 1 , wherein the sensor information is received from at least one sensor provided on or implanted in the patient.

3 . The system of claim 2 , wherein the at least one sensor comprises at least one of a wearable sensor, an implantable sensor, and an environmental sensor, and wherein the sensor information is received via a wireless communication signal from the at least one sensor.

4 . The system of claim 1 , wherein the one or more parameters comprise at least one of frequency, peak current, duty cycle, and application duration.

5 . The system of claim 1 , wherein memory further stores data that, when processed by the processor, causes the processor to:
estimate a sympathetic tone based on the sensor information describing the subcutaneous nerve activity.

6 . The system of claim 1 , further comprising:
a user interface that allows at least one of the patient and a clinician to provide inputs to describe an aspect of the subcutaneous nerve activity.

7 . The system of claim 1 , wherein the one or more splanchnic nerves comprises at least one of a greater splanchnic nerve, a lesser splanchnic nerve, and a least splanchnic nerve.

8 . The system of claim 1 , wherein the one or more parameters of the implantable pulse generator are adjusted to increase a nerve blocking applied at the one or more splanchnic nerves.

9 . The system of claim 1 , wherein the one or more parameters of the implantable pulse generator are adjusted to decrease a nerve blocking applied at the one or more splanchnic nerves.

10 . The system of claim 1 , wherein the one or more parameters of the implantable pulse generator are adjusted to increase a nerve stimulation applied at the one or more splanchnic nerves.

11 . The system of claim 1 , wherein the one or more parameters of the implantable pulse generator are adjusted to decrease a nerve stimulation applied at the one or more splanchnic nerves.

12 . The system of claim 1 , wherein the sensor information is received from at least one of the plurality of electrodes.

13 . A control subsystem for use in a therapeutic system, the control subsystem comprising:
a processor; and a memory storing data for processing by the processor, the data, when processed, causes the processor to:
receive sensor information describing subcutaneous nerve activity of a patient; and
determine an electrical signal applied by an implantable pulse generator to a splanchnic nerve of the patient is to be adjusted based on the subcutaneous nerve activity; and
transmit a control signal to the implantable pulse generator thereby causing the implantable pulse generator to adjust the electrical signal applied to the splanchnic nerve.

14 . The system of claim 13 , wherein the electrical signal comprises at least one of a blocking signal that provides a nerve block and a stimulation signal that provides a nerve stimulation to the splanchnic nerve.

15 . The system of claim 14 , wherein the splanchnic nerve comprises at least one of a greater splanchnic nerve, a lesser splanchnic nerve, and a least splanchnic nerve.

16 . The system of claim 13 , wherein the sensor information is received from at least one sensor provided on or implanted in the patient.

17 . The system of claim 13 , wherein one or more parameters of the electrical signal are adjusted and wherein the one or more parameters include at least one of frequency, peak current, duty cycle, and application duration.

18 . A method, comprising:
determining a first state of a therapy for a patient, wherein the first state of the therapy includes providing electrical signals to one or more splanchnic nerves of the patient; receiving sensor information from one or more sensors; based on the received sensor information, determining a subcutaneous nerve activity associated with the patient; and based on the subcutaneous nerve activity, adjusting one or more parameters of the electrical signals to change the therapy from the first state to a second state.

19 . The method of claim 18 , wherein the first state of the therapy further comprises a unilateral ablation of at least a portion of the splanchnic nerve.

20 . The method of claim 18 , wherein the electrical signals are applied bilaterally to the one or more splanchnic nerves and wherein adjusting the one or more parameters comprises changing at least one of a frequency, peak current, duty cycle, and application duration for the electrical signals.

Assignees

• Medtronic Inc

Inventors

• Miller David John
• Shrivastav Maneesh
• Musley Shaileshkumar V

Classifications

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/36135

  using physiological parameters · CPC title

• A61N1/36057

  adapted for stimulating afferent nerves · CPC title

• A61N1/36071

  Pain · CPC title

• A61N1/36139 Primary

  with automatic adjustment · CPC title