Reconfigurable bioprocessing systems

Patent metadata

Field	Value
Publication number	US-2024150697-A1
Application number	US-202218550075-A
Country	US
Kind code	A1
Filing date	Apr 25, 2022
Priority date	Apr 26, 2021
Publication date	May 9, 2024
Grant date	—

Abstract

The present invention relates to a reconfigurable bioprocessing system ( 80 ) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system ( 80 ) comprises a base unit ( 60 ) comprising a plurality of valve actuators ( 102 ). At least one of the plurality of valve actuators ( 102 ) is operable to releasably engage with at least part of a pinch valve cassette ( 103, 203 ) to control fluid flow through the pinch valve cassette ( 103, 203 ). At least part of the pinch valve cassette ( 103, 203 ) is removably attachable to the base unit ( 60 ) and the pinch valve cassette ( 103, 203 ) is provided adjacent to said plurality of valve actuators ( 102 ). The reconfigurable bioprocessing system ( 80 ) also includes a control system operable to selectively actuate respective of said plurality of valve actuators ( 102 ) to provide a valve configuration within the pinch valve cassette ( 103, 203 ) to enable the base unit ( 60 ) and the pinch valve cassette ( 103, 203 ) together to perform one of the predetermined set of bioprocessing operations. A flow kit ( 107 ) for use in reconfigurable bioprocessing systems ( 80 ) and various methods ( 1000 ) for reconfiguring bioprocessing systems ( 80 ) (e.g. automatically) are also disclosed.

First claim

1 . A reconfigurable bioprocessing system operable to perform a predetermined set of bioprocessing operations therein, the reconfigurable bioprocessing system comprising:
a base unit comprising a plurality of valve actuators, wherein at least one of the plurality of valve actuators is operable to releasably engage with at least part of a pinch valve cassette to control fluid flow through the pinch valve cassette, and wherein at least part of the pinch valve cassette is removably attachable to the base unit; and a control system operable to selectively actuate respective of said plurality of valve actuators to provide a valve configuration within the pinch valve cassette to enable the base unit and the pinch valve cassette together to perform one of the predetermined set of bioprocessing operations.

2 . The bioprocessing system of claim 1 , wherein the plurality of valve actuators are provided at an actuator plate attached to the bioprocessing system base unit in a pattern.

3 . The bioprocessing system of claim 1 , wherein the pattern includes at least one non-rectangular or non-square arrangement of valve actuators.

4 . The bioprocessing system of claim 3 , wherein said arrangement of valve actuators includes at least one hexagonal, quincunx and/or triangular actuator arrangement.

5 . The bioprocessing system of any of the claim 1 , wherein the predetermined set of bioprocessing operations comprises one or more of: a chromatography operation, a mixing operation and/or a filtration operation.

6 . The bioprocessing system of claim 1 , wherein the plurality of valve actuators are operable as pinch valve actuators in conjunction with the pinch valve cassette.

7 . The bioprocessing system of claim 1 , wherein the pinch valve cassette comprises a flexible tubing manifold comprising a conduit or a plurality of interconnected conduits.

8 . The bioprocessing system of claim 7 , wherein the flexible tubing manifold comprises at least one elastomeric material and/or is optionally reinforced.

9 . The bioprocessing system of claim 8 , wherein said at least one elastomeric material includes one or more of: silicone rubber; a thermoplastic elastomer (TPE); and/or a thermoplastic rubber (TPR).

10 . The bioprocessing system of claim 1 , wherein the pinch valve cassette comprises a lock plate that is removably attachable to the base unit.

11 . The bioprocessing system of claim 1 , further operable to automatically identify said pinch valve cassette when at least said removable part thereof is attached to said base unit for use.

12 . The bioprocessing system of claim 11 , further operable to automatically configure said base unit to perform a specific bioprocessing operation, selected from said predetermined set of bioprocessing operations, in connection with said pinch valve cassette in dependence upon said automatic identification of said pinch valve cassette or said removable part thereof.

13 . A flow kit comprising at least a flexible tubing manifold for use in a pinch valve cassette, said flow kit being removably attachable to the bioprocessing system of claim 1 .

14 . The flow kit of claim 13 , further comprising at least one of: i) at least one flexible tubing manifold comprising a plurality of interconnected conduits, wherein the at least one flexible tubing manifold is configured to be removably housed within one or more channels defined by an actuator plate and/or a lock plate; ii) an actuator plate; iii) a lock plate; iv) an intermediate actuator depth adapter; and/or v) an exoskeleton insert for housing said at least a flexible tubing manifold.

15 . The flow kit as claimed in claim 13 , wherein the at least one flexible tubing manifold comprises webbing provided between at least two interconnected conduits of a plurality of interconnected conduits and/or wherein the at least one flexible tubing manifold is substantially “jumping Jack”, asterisk or star shaped.

16 . A method for reconfiguring a bioprocessing system, comprising:
replacing a first flow kit in the bioprocessing system with a second flow kit for performing a bioprocessing operation that is different from that associated with said first flow kit; identifying a model/type of the second flow kit; and reconfiguring; the bioprocessing system based upon the model/type identification information of the second flow kit.

17 . The method of claim 16 , comprising identifying a model/type of the second flow kit by automatically identifying at least part of a pinch valve cassette when it is provided for said bioprocessing system.

Assignees

• Cytiva Sweden Ab

Inventors

• Gebauer Klaus
• Francois Tim
• Lundin Andreas
• Olovsson Bjorn Markus
• Erickson Kerstin
• Dalmo Tomas

Classifications

• C12M23/40 Primary

  Manifolds; Distribution pieces (fluid transfer means B01L3/563) · CPC title

• C12M23/28

  disposable or single use · CPC title

• C12M23/44

  Multiple separable units; Modules · CPC title

• C12M29/04

  Filters; Permeable or porous membranes or plates, e.g. dialysis · CPC title

• C12M29/06

  Nozzles; Sprayers; Spargers; Diffusers (per se B01F23/231, B01J19/26) · CPC title