Process of recovering 3-hydroxypropionic acid and slurry composition comprising 3-hydroxypropionic acid

Patent metadata

Field	Value
Publication number	US-2024141394-A1
Application number	US-202218570184-A
Country	US
Kind code	A1
Filing date	Nov 28, 2022
Priority date	Nov 29, 2021
Publication date	May 2, 2024
Grant date	—

Abstract

The present invention relates to a process of recovering 3-hydroxypropionic acid, comprising: forming a 3-hydroxypropionate crystal in a concentrate containing 3-hydroxypropionic acid in the presence of an alkali metal salt, preparing a solution containing 3-hydroxypropionate crystal separated from the concentrate, stirring an acid and the solution containing 3-hydroxypropionate crystal to form a precipitate, and subjecting the precipitate to a first washing, and a slurry composition comprising a precipitate prepared in the process of recovering 3-hydroxypropionic acid and 3-hydroxypropionic acid.

First claim

1 . A process of recovering 3-hydroxypropionic acid, comprising:
forming a 3-hydroxypropionate crystal in a concentrate containing 3-hydroxypropionic acid in the presence of an alkali metal salt; preparing a solution containing 3-hydroxypropionate crystal separated from the concentrate; stirring an acid and the solution containing 3-hydroxypropionate crystal to form a precipitate; and first washing the precipitate using a first washing liquid.

2 . The process of recovering 3-hydroxypropionic acid according to claim 1 ,
further comprising reusing the first washing liquid used in the first washing of the precipitate.

3 . The process of recovering 3-hydroxypropionic acid according to claim 1 ,
further comprising adding the acid to the solution containing 3-hydroxypropionate crystal at a temperature of 30° C. or more and 90° C. or less before the stirring of the acid and the solution containing 3-hydroxypropionate crystal to form a precipitate.

4 . The process of recovering 3-hydroxypropionic acid according to claim 1 ,
further comprising charging the acid and the solution containing 3-hydroxypropionate crystal into a reactor, either continuously or in 2 or more installments before the stirring of the acid and the solution containing 3-hydroxypropionate crystal to form a precipitate.

5 . The process of recovering 3-hydroxypropionic acid according to claim 4 , wherein:
the solution containing 3-hydroxypropionate crystal is continuously charged into the reactor.

6 . The process of recovering 3-hydroxypropionic acid according to claim 4 , wherein:
the acid is charged into the reactor in 3 or more installments and 20 or less installments.

7 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
a content of the acid is 20 wt. % or more and 80 wt. % or less with respect to 100 wt. % of the 3-hydroxypropionate crystal.

8 . The process of recovering 3-hydroxypropionic acid according to claim 1 , the process further comprising,
after the first washing the precipitate using a first washing liquid, second washing the first washed precipitate using a second washing liquid and reusing the used second washing liquid.

9 . The process of recovering 3-hydroxypropionic acid according to claim 8 , wherein:
at least one washing liquid selected from the first washing liquid and the second washing liquid is reused as a solvent in the preparing of the solution containing 3-hydroxypropionate crystal separated from the concentrate.

10 . The process of recovering 3-hydroxypropionic acid according to claim 8 , wherein:
at least one washing liquid selected from the first washing liquid and the second washing liquid is mixed with a filtrate in which the precipitate has been filtered to prepare a mixed liquid, and the 3-hydroxypropionic acid is recovered from the mixed liquid.

11 . The process of recovering 3-hydroxypropionic acid according to claim 8 , further comprising:
fermenting a bacterium strain having 3-hydroxypropionic acid-producing ability to produce a 3-hydroxypropionic acid fermentation liquid; and concentrating the fermentation liquid to form the concentrate containing 3-hydroxypropionic acid, wherein at least one washing liquid selected from the first washing liquid and the second washing liquid is reused in the fermenting of a bacterium strain having 3-hydroxypropionic acid-producing ability to produce the 3-hydroxypropionic acid fermentation liquid.

12 . The process of recovering 3-hydroxypropionic acid according to claim 11 , wherein:
the concentrating of the fermentation liquid to form the concentrate containing 3-hydroxypropionic acid is carried out by evaporating the fermentation liquid, and the moisture removed by the evaporation is liquefied and reused for at least one washing selected from the first washing and the second washing.

13 . The process of recovering 3-hydroxypropionic acid according to claim 8 ,
further comprising drying at least one of the first and second washed precipitates, wherein the moisture removed by the drying is liquefied and reused for at least one washing selected from the first washing and the second washing.

14 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the precipitate is represented by the following structural formula 3:
Cation(Anion)·pH 2 O  [Structural Formula 3]

wherein, Cation is a cation of the alkali metal salt, Anion is an anion of the acid, and p is the number of water molecules in the hydrate, which is an integer of 1 or more.

15 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
a particle size of the precipitate is at least 1.0 μm.

16 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
a moisture content of the precipitate is 150% or less.

17 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the 3-hydroxypropionate crystal is represented by the following structural formula 1 or structural formula 2:
Cation(3HP) n   [Structural Formula 1]

Cation(3HP) n ·m H 2 O  [Structural Formula 2]

wherein, Cation is a cation of the alkali metal salt, 3HP is 3-hydroxypropionic acid that binds to the cation, n is the number of 3HP that binds to the cation, which is an integer of 1 or more, and m is the number of water molecules in the hydrate, which is an integer of 1 or more.

18 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the alkali metal salt is Ca(OH) 2 , Mg(OH) 2 , or a mixture thereof.

19 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the 3-hydroxypropionate crystal has a particle size distribution D 50 of 20 μm or more and 90 μm or less, and a (D 90 −D 10 )/D 50 of 1.00 or more and 3.00 or less.

20 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
a recovery rate of 3-hydroxypropionic acid is at least 40%.

21 . A slurry composition comprising a precipitate represented by the following structural formula 4 and 3-hydroxypropionic acid.
Cation(Anion)·pH 2 O  [Structural Formula 4]
wherein, Cation is Na + , Mg 2+ or Ca 2+ , Anion is SO 4 2− , PO 4 3− or CO 3 2− , and p is the number of water molecules in the hydrate, which is an integer of 1 or more.

22 . The slurry composition according to claim 21 , wherein:
a particle size of the precipitate is at least 1.0 μm.

23 . The slurry composition according to claim 21 , wherein:
a moisture content of the precipitate is 150% or less.

Assignees

• Lg Chemical Ltd

Inventors

• Kim Jeong Eun
• Bang Yongju
• Choe Jae Hoon
• Kang Donggyun
• Cho Ara
• Jung Woochul
• Han Sang Won
• Kim Taeho

Classifications

• B01D9/00 Primary

  Crystallisation (crystallisation directly from the vapour phase B01D7/02; making single crystals C30B {; crystallisation as part of the Bayer process also classified in C01F7/14}) · CPC title

• C07C59/01

  Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups · CPC title

• C12P7/42

  Hydroxy-carboxylic acids · CPC title

• C12P7/52 Primary

  Propionic acid; Butyric acids · CPC title

• C07C51/43 Primary

  by change of the physical state, e.g. crystallisation · CPC title