Bioactive glass compositions

Patent metadata

Field	Value
Publication number	US-2024140854-A1
Application number	US-202218279254-A
Country	US
Kind code	A1
Filing date	Mar 1, 2022
Priority date	Mar 4, 2021
Publication date	May 2, 2024
Grant date	—

Abstract

A silicate-based glass composition includes 15-65 wt. % SiO2, 2.5-25 wt. % MgO, 1-30 wt. % P2O5, and 15-50 wt. % CaO, such that the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719) and forms a bioactive crystalline phase in a simulated body fluid.

First claim

1 . A silicate-based glass composition, comprising:
15-65 wt. % SiO 2 , 2.5-25 wt. % MgO, 1-30 wt. % P 2 O 5 , and 15-50 wt. % CaO, wherein the composition:
has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and
forms a bioactive crystalline phase in a simulated body fluid.

2 . The glass composition of claim 1 , further comprising:
>0-5 wt. % F − .

3 . The glass composition of claim 1 , further comprising one of:
>0-10 wt. % Li 2 O, >0-10 wt. % Na 2 O, or >0-10 wt. % K 2 O.

4 . The glass composition of claim 1 , further comprising:
>0 to 10 wt. % ZrO 2 .

5 . The glass composition of claim 1 , further comprising:
0-10 wt. % Al 2 O 3 , 0-10 wt. % SrO, 0-10 wt. % ZnO, and 0-5 wt. % B 2 O 3 .

6 . The glass composition of claim 1 , wherein the glass comprises:
15-50 wt. % MO, and 0-30 wt. % R 2 O, wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO, and R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O.

7 . The glass composition of claim 1 , wherein the bioactive crystalline phase comprises apatite.

8 . The glass composition of claim 1 , wherein a sum of P 2 O 5 and CaO is from 25-65 wt. %.

9 . A silicate-based glass composition, comprising:
30-50 wt. % SiO 2 , 10-20 wt. % MgO, 5-15 wt. % P 2 O 5 , and 25-40 wt. % CaO, wherein the composition:
has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and
forms a bioactive crystalline phase in a simulated body fluid.

10 . The glass composition of claim 9 , further comprising:
>0-3 wt. % F − .

11 . The glass composition of claim 9 , further comprising one of:
>0-10 wt. % Li 2 O, >0-10 wt. % Na 2 O, or >0-10 wt. % K 2 O.

12 . The glass composition of claim 9 , further comprising:
>0 to 10 wt. % ZrO 2 .

13 . The glass composition of claim 9 , wherein the bioactive crystalline phase comprises apatite.

14 . The glass composition of claim 9 , wherein a sum of P 2 O 5 and CaO is from 25-65 wt. %.

15 . A matrix comprising the glass composition of claim 1 , wherein:
the matrix includes at least one of: a toothpaste, mouthwash, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation.

16 . The matrix of claim 15 , wherein the glass composition is attached to the matrix or mixed therein.

17 . An aqueous environment comprising the glass composition of claim 1 .

Assignees

• Corning Inc

Inventors

• Fu Qiang
• Li Aize
• Mcmahon Hugh Michael

Classifications

• C03C3/078 Primary

  containing an oxide of a divalent metal, e.g. an oxide of zinc · CPC title

• C03B37/02

  by drawing or extruding, {e.g. direct drawing of molten glass from nozzles; Cooling fins therefor (C03B37/04 takes precedence; sizing of the fibres C03C25/00)} · CPC title

• C03C3/062

  with less than 40% silica by weight · CPC title

• C03C3/097 Primary

  containing phosphorus, niobium or tantalum · CPC title

• C03C3/112

  containing fluorine · CPC title