Systems and methods for direct suppression of nerve cells

Patent metadata

Field	Value
Publication number	US-2024139513-A1
Application number	US-202318486338-A
Country	US
Kind code	A1
Filing date	Oct 13, 2023
Priority date	Jan 25, 2020
Publication date	May 2, 2024
Grant date	—

Abstract

The present technology provides systems and methods for directly suppressing nerve cells by delivering electrical stimulation having relatively long pulse widths and at amplitudes below an activation threshold of the nerve cells. For example, some embodiments include delivering a therapy signal having individual pulses with pulse widths of between about 5 ms and 100 ms. Directly suppressing the nerve cells is expected to reduce the transmission of pain signals.

First claim

1 - 58 . (canceled)

59 . A method for treating a patient, comprising:
programming a signal generator to deliver an electrical signal having a pulse width in a pulse width range of from about 600 milliseconds to about 2 seconds to a target neural population in the patient's spinal cord region via at least one implanted signal delivery element.

60 . The method of claim 59 wherein the pulse width range is from about 800 milliseconds to about 2 seconds.

61 . The method of claim 59 wherein the pulse width range is from about 1 second to about 2 seconds.

62 . The method of claim 59 wherein the electrical signal includes biphasic pulses having an anodic pulse phase and a cathodic pulse phase, and wherein at least one of the anodic pulse phase or the cathodic pulse phase has the pulse width in the pulse width range of from about 600 milliseconds to about 2 seconds.

63 . The method of claim 62 wherein the anodic pulse phase and the cathodic pulse phase each have a pulse width in the pulse width range of from about 600 milliseconds to about 2 seconds.

64 . The method of claim 59 wherein the electrical signal includes monophasic pulses, and wherein individual monophasic pulses have the pulse width in the pulse width range of from about 600 milliseconds to about 2 seconds.

65 . The method of claim 59 wherein the electrical signal has an amplitude below an activation threshold of the target neural population

66 . The method of claim 59 wherein the electrical signal has an amplitude between about 0.1 mA and about 3 mA.

67 . The method of claim 59 , further comprising:
determining a maximum amplitude of the electrical signal that does not evoke a clinically discernable response, wherein programming the signal generator includes programming the signal generator to deliver an electrical signal having an amplitude less than or equal to the maximum amplitude.

68 . The method of claim 59 wherein the electrical signal directly suppresses at least a subset of the target neural population.

69 . A method for treating a patient, comprising:
applying an electrical signal having a pulse width in a pulse width range of from about 600 milliseconds to about 2 seconds to a target neural population in the patient's spinal cord region via at least one implanted signal delivery element.

70 . The method of claim 69 wherein the pulse width range is from about 800 milliseconds to about 2 seconds.

71 . The method of claim 69 wherein the pulse width range is from about 1 second to about 2 seconds.

72 . The method of claim 69 wherein the electrical signal includes biphasic pulses having an anodic pulse phase and a cathodic pulse phase, and wherein at least one of the anodic pulse phase or the cathodic pulse phase has the pulse width in the pulse width range of from about 600 milliseconds to about 2 seconds.

73 . The method of claim 72 wherein the anodic pulse phase and the cathodic pulse phase each have a pulse width in the pulse width range of from about 600 milliseconds to about 2 seconds.

74 . The method of claim 69 wherein the electrical signal includes monophasic pulses, and wherein individual monophasic pulses have the pulse width in the pulse width range of from about 600 milliseconds to about 2 seconds.

75 . The method of claim 69 wherein the electrical signal directly suppresses at least a subset of the target neural population.

76 . A system for treating a patient, comprising:
a signal generator programmed with instructions that, when executed, cause the signal generator to generate an electrical signal having a pulse width in a pulse width range of from about 600 milliseconds to about 2 seconds; and a signal delivery element implantable in the patient's spinal cord region proximate a target neural population, wherein, in operation, the signal delivery element delivers the electrical signal to the target neural population.

77 . The system of claim 76 wherein the pulse width range is from about 800 milliseconds to about 2 seconds.

78 . The system of claim 76 wherein the pulse width range is from about 1 second to about 2 seconds.

Assignees

• Nevro Corp

Inventors

• Bradley Kerry
• Lee Dongchul

Classifications

• A61N1/36071 Primary

  Pain · CPC title

• A61N1/36062 Primary

  Spinal stimulation · CPC title

• A61N1/36175

  Pulse width or duty cycle · CPC title

• A61N1/36192

  Amplitude modulation · CPC title

• A61N1/3616

  Voltage density or current density · CPC title