Assessment and Management of Adverse Event Risks in Mechanical Circulatory Support Patients

Patent metadata

Field	Value
Publication number	US-2024139498-A1
Application number	US-202318498765-A
Country	US
Kind code	A1
Filing date	Oct 31, 2023
Priority date	Nov 1, 2022
Publication date	May 2, 2024
Grant date	—

Abstract

Systems and methods for assessment and management of adverse event risks in mechanical circulatory support patients are described herein. The method for post-operative risk mitigation in patients with an implanted Ventricular Assist Device (VAD) can include receiving a plurality of features relating to an attribute associated with the patient and ingesting at least some of the features into a multistate model. The multistate model can include a plurality of states, each corresponding to a patient condition. The method can include generating with the multistate model a daily prediction of a likelihood of the patient developing at least one of the conditions corresponding to the plurality of states in a predetermined time period, and controlling a user interface to output an indicator of the likelihood of the patient developing the at least one of the conditions in the predetermined time period.

First claim

1 . A method of post-operative risk mitigation in patients with an implanted Ventricular Assist Device (VAD), the method comprising:
receiving a plurality of features, each of the features relating to an attribute associated with the patient having received the implanted VAD; inputting at least some of the features into a multistate model, the multistate model comprising a plurality of states including at least one of stroke, death, and gastrointestinal bleeding, each of the states corresponding to a patient condition; generating with the multistate model a daily prediction of a likelihood of the patient developing at least one of the conditions corresponding to the plurality of states in a predetermined time period; and outputting on a user interface an indicator of the likelihood of the patient developing the at least one of the conditions in the predetermined time period so as to manage post-operative risk from VAD implantation.

2 . The method of claim 1 , wherein generating with the multistate model the daily prediction of the likelihood of the patient developing at least one of the conditions corresponding to the plurality of states in the predetermined time period comprises generating with the multistate model the daily prediction of the likelihood of the patient developing a first set of conditions corresponding to a first set of states;
and wherein outputting the indicator of the likelihood of the patient developing the at least one of the conditions in the predetermined time period comprises outputting the indicator of the likelihood of the patient developing a second set of conditions corresponding to a second set of states in the predetermined time period.

3 . The method of claim 2 , wherein the first set of conditions corresponding to the first set of states is greater than the second set of conditions corresponding to the second set of states.

4 . The method of claim 2 , wherein the first set of conditions corresponding to the first set of states is less than the second set of conditions corresponding to the second set of states.

5 . The method of claim 1 , wherein the multistate model generates the daily prediction for conditions corresponding to a greater number of states than are output via the indicator of the user interface.

6 . The method of claim 1 , wherein the plurality of features comprise at least: a baseline feature indicating a pre-operative condition of the patient; an implantation feature indicating a condition of the patient during implantation of the VAD; and a post-implantation feature indicative of a post-operative condition of the patient.

7 . The method of claim 6 , wherein the post-implantation feature is time-varying.

8 . The method of claim 7 , wherein the post-implantation feature identifies an operating attribute of the VAD.

9 . The method of claim 8 , wherein the operating attribute of the VAD comprises at least one of: a pump pulsatility index; a pump power; and a pump speed.

10 . The method of claim 1 , further comprising generating a control signal affecting an operating attribute of the VAD.

11 . The method of claim 10 , wherein the operating attribute of the VAD comprises at least one of: a pump pulsatility index; a pump power; and a pump speed.

12 . The method of claim 1 , wherein the daily prediction is generated each day for a plurality of days.

13 . The method of claim 12 , further comprising outputting with the user interface at least one trendline based on an aggregate of generated daily predictions.

14 . The method of claim 13 , wherein the at least one trendline comprises one trendline associated with one of the at least one of the conditions corresponding to one of the plurality of states.

15 . The method of claim 14 , wherein the one trendline indicates a change in risk with respect to time for the one of the at least one of the conditions corresponding to one of the plurality of states associated with the one trendline.

16 . The method of claim 13 , further comprising:
determining a change in one of the at least one trendline, the change indicating an increased risk; and generating an alert based on the change in the one of the at least one trendline.

17 . The method of claim 16 , further comprising generating a modified treatment regime based on the change in the one of the at least one trendline.

18 . The method of claim 13 , further comprising:
determining a change in one of the at least one trendline, the change indicating a decreased risk; and generating an alert based on the change in the trendline.

19 . The method of claim 1 , further comprising:
determining that at least some of the received plurality of features are aged; and generating replacement features for at least some of the aged plurality of features; and wherein the features inputted into the multistate model include the replacement features and the non-aged features.

20 . The method of claim 19 , wherein generating replacement features comprises:
selecting a replacement model for generating the replacement features; and generating replacement features with the replacement model.

21 . The method of claim 20 , wherein the replacement model comprises a patient cohort selected based on a commonality of at least one attribute with the patient having received the implanted VAD.

22 . The method of claim 20 , wherein the replacement model selects a most recent value for use as replacement data.

23 . The method of claim 1 , further comprising:
determining that at least some of the received plurality of features are aged; and determining to generate new features replacing at least one of the aged plurality of features; and scheduling an action to generate the new features.

24 . The method of claim 23 , wherein the daily prediction of the likelihood of the patient developing the at least one of the conditions corresponding to the plurality of states is generated when the new features is generated.

25 . The method of claim 1 , wherein the multistate model utilizes logistic regression to estimate transition probability.

26 .- 51 . (canceled)

Assignees

• Tc1 Llc

Inventors

• Agarwal Rahul
• Bharmi Rupinder
• Kormos Robert L
• Hu Yajing
• Lu Qianhul
• Shah Palak

Classifications

• A61M60/178 Primary

  drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices · CPC title

• G16H50/30

  for calculating health indices; for individual health risk assessment · CPC title

• A61M2205/18

  with alarm · CPC title

• G16H20/40 Primary

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title

• A61B5/7275

  Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor · CPC title