Process of making nanoemulsion

Patent metadata

Field	Value
Publication number	US-2024130967-A1
Application number	US-202318397626-A
Country	US
Kind code	A1
Filing date	Dec 27, 2023
Priority date	Dec 9, 2019
Publication date	Apr 25, 2024
Grant date	—

Abstract

The disclosure provides a nanoemulsion including an oil phase containing at least one cannabinoid and a water phase; wherein at least one of the oil phase and the water phase includes one or more emulsifying agents; and wherein the zeta potential of the nanoemulsion is less than about −10 mV. Further provided are processes for preparing such nanoemulsions.

First claim

1 . A nanoemulsion comprising at least one cannabinoid, wherein the nanoemulsion is obtained or obtainable by a process comprising:
(a) providing an oil phase containing at least one cannabinoid; (b) providing a water phase (c) combining the oil phase and water phase to form a macroemulsion; and (d) treating the macroemulsion to form a nanoemulsion.

2 . The nanoemulsion of claim 1 , wherein a zeta potential of the nanoemulsion is less than about −10 mV.

3 . The nanoemulsion of claim 1 , wherein the nanoemulsion comprises droplets of the oil phase dispersed in the water phase, the droplets having an average diameter from about 1 nm to about 200 nm.

4 . An oral product containing the nanoemulsion of claim 1 .

5 . The oral product of claim 4 , further comprising a filler.

6 . The oral product of claim 4 , wherein a water activity of the oral product is no greater than about 0.85.

7 . A pouched oral product comprising a saliva permeable pouch and the oral product of claim 4 incorporated within the pouch.

8 . A package containing at least one pouched oral product of claim 7 .

9 . A nanoemulsion comprising:
(a) an oil phase containing at least one cannabinoid; and (b) a water phase; wherein at least one of the oil phase and the water phase comprises one or more emulsifying agents, and wherein a zeta potential of the nanoemulsion is less than about −10 mV.

10 . The nanoemulsion of claim 9 , comprising droplets of the oil phase dispersed in the water phase, the droplets having an average diameter from about 1 nm to about 200 nm.

11 . The nanoemulsion of claim 9 , wherein a weight ratio of the oil phase to the water phase is from about 2:1 to about 1:10.

12 . The nanoemulsion of claim 9 , wherein a weight ratio of the oil to the at least one cannabinoid is from about 1:1 to about 10:1.

13 . The nanoemulsion of claim 9 , wherein the oil phase comprises castor oil.

14 . The nanoemulsion of claim 9 , wherein the at least one cannabinoid is selected from the group consisting of cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN) and cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidiolic acid (CBDA), Cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabmolic acid (THCA), tetrahydrocannabivarinic acid (THCV A), and mixtures thereof.

15 . The nanoemulsion of claim 9 , wherein the at least one cannabinoid comprises cannabidiol.

16 . The nanoemulsion of claim 9 , wherein the one or more emulsifying agents comprises a first emulsifying agent having an HLB value of from about 1 to about 9, and a second emulsifying agent having an HLB value of from about 10 to about 20.

17 . The nanoemulsion of claim 16 , wherein the first emulsifying agent is selected from the group consisting of glycol distearate, sorbitan trioleate, sorbitan tristearate, sorbitan triisostearate, glyceryl isostearate, propylene glycol isostearate, glycol stearate, sorbitan sesquioleate, glyceryl stearate, lecithin, sorbitan oleate, sorbitan monostearate, sorbitan stearate, sorbitan isostearate, steareth-2, oleth-2, polyethyleneglycol (PEG)-7 hydrogenated castor oil, laureth-2, sorbitan palmitate, laureth-3, glyceryl laurate, ceteth-2, PEG-30 dipolyhdroxystearate, glyceryl stearate self-emulsifying (SE), sorbitan stearate/sucrose cocoate, PEG-4 dilaurate, methyl glucose sesquistearate, PEG-8 dioleate, sorbitan laurate, PEG-40 sorbitan peroleate, and mixtures thereof.

18 . The nanoemulsion of claim 16 , wherein the second emulsifying agent is selected from the group consisting of laureth-4, polyethyleneglycol (PEG)-7 glyceryl cocoate, PEG-20 almond glycerides, PEG-25 hydrogenated castor oil, stearamide MEA, glyceryl stearate (and)/PEG-100 stearate, polysorbate 81, polysorbate 85, polysorbate 65, PEG-7 glyceryl cocoate, PEG-8 stearate, PEG-8 caprate, PEG-35 almond glycerides, PEG-6 laurate, laureth-7, steareth-10, isotrideceth-8, PEG-35 castor oil, isotrideceth-9, PEG-40 castor oil, ceteareth-12, laureth-9, PEG-40 hydrogenated castor oil, PEG-20 glyceryl isostearate, PEG-20 stearate, PEG-40 sorbitan perisostearate, PEG-7 olivate, cetearyl glucoside, PEG-8 oleate, polyglyceryl-3 methylglucose distearate, oleth-10, oleth-10/polyoxyl 10 oleyl ether, ceteth-10, PEG-8 laurate, cocamide monoethanolamide (MEA), polysorbate 60, polysorbate 80, isosteareth-20, PEG-60 almond glycerides, PEG-20 methyl glucose sesquistearate, ceteareth-20, oleth-20, steareth-20, steareth-21, ceteth-20, isoceth-20, polysorbate 20, polysorbate 40, ceteareth-25, ceteareth-30, PEG-30 stearate, laureth-23, PEG-75 lanolin, polysorbate 20, PEG-40 stearate, PEG-100 stearate, steareth-100, PEG-80 sorbitan laurate, polyoxyethylene stearates (e.g., polyoxyethylene (40) stearate), polyoxyethylene ethers, and mixtures thereof.

Assignees

• Nicoventures Trading Ltd

Inventors

• Gerardi Anthony Richard
• Poole Thomas H
• Alderman Steven Lee

Classifications

• A61K31/658

  o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol · CPC title

• A24B15/303 Primary

  Plant extracts other than tobacco · CPC title

• A61K9/009 Primary

  Sachets, pouches characterised by the material or function of the envelope (with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095) · CPC title

• A24B13/00

  Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff (reconstituted tobacco products A24B3/14) · CPC title

• A24B15/16

  of tobacco substitutes · CPC title