Coaxial needle adapter and guide bracket for robotic liquid handling platform

Patent metadata

Field	Value
Publication number	US-2024082110-A1
Application number	US-202218275520-A
Country	US
Kind code	A1
Filing date	Feb 1, 2022
Priority date	Feb 3, 2021
Publication date	Mar 14, 2024
Grant date	—

Abstract

A drug reconstitution system includes a robotic arm movable between a plurality of positions, at least one bracket member operably coupled with the robotic arm, and at least one coaxial needle operably coupled with the robotic arm. The at least one bracket member includes a mounting region, a support surface, an upper surface, and a throughbore extending through the support surface and the upper surface. The at least one coaxial needle is movably disposed between the throughbore of the at least one bracket member. The at least one coaxial needle is adapted to pierce at least a portion of a vial and dispense a liquid into the vial during drug reconstitution.

First claim

1 . A drug reconstitution system comprising:
a robotic arm movable between a plurality of positions; at least one bracket member operably coupled with the robotic arm, the at least one bracket member including a mounting region, a support surface, an upper surface, and a throughbore extending through the support surface and the upper surface; and at least one coaxial needle operably coupled with the robotic arm and being movably disposed between the throughbore of the at least one bracket member, wherein the at least one coaxial needle is adapted to pierce at least a portion of a vial and dispense a liquid into the vial during drug reconstitution.

2 . The drug reconstitution system of claim 1 , wherein the at least one coaxial needle includes a proximal end, a distal end, an elongated length extending therebetween, a piercing tip positioned at the proximal end, a dispensing opening positioned at or near the proximal end, and a first venting hole positioned along the elongated length.

3 . The drug reconstitution system of claim 2 , wherein the piercing tip and the dispensing opening of the at least one coaxial needle are disposed on an inner member and the first venting hole is disposed on an outer member, the outer member being at least partially hollow to receive at least a portion of the inner member.

4 . The drug reconstitution system of claim 3 , further comprising a second venting hole disposed on the outer member distally from the first venting hole, wherein the first venting hole and the second venting hole cooperate to create a venting path to an external environment.

5 . The drug reconstitution system of claim 1 , wherein the support surface of the at least one bracket member is adapted to engage a contact face of a drug vial during at least one of drug aspiration or drug reconstitution via movement of the robotic arm to a lowered position.

6 . The drug reconstitution system of claim 5 , wherein the at least one coaxial needle is adapted to be movable relative to the at least one bracket member such that the at least one coaxial needle may be selectively raised while the support surface of the at least one bracket member remains engaged with the contact face of the drug vial.

7 . The drug reconstitution system of claim 6 , further comprising an urging member adapted to exert an urging force on the at least one bracket member.

8 . The drug reconstitution system of claim 1 , further comprising a needle assembly operably coupled with the robotic arm, the at least one bracket member, and the at least one coaxial needle, the needle assembly including a liquid reservoir to dispense into the at least one coaxial needle.

9 . A method of reconstituting a drug via a robotic arm movable between a plurality of positions, the method comprising:
operably coupling at least one bracket member with the robotic arm; operably coupling at least one coaxial needle with the robotic arm, the at least one coaxial needle being fluidly coupled with a reconstituting fluid; lowering the robotic arm to a lowered position whereby the at least one bracket member and the at least one coaxial needle move to a lowered position adjacent to a drug vial; reconstituting the drug by causing the reconstituting fluid to flow through at least a portion of the at least one coaxial needle; raising the at least one coaxial needle to a raised position while the at least one bracket member remains adjacent to the drug vial; and raising the at least one bracket member to a raised position.

10 . The method of claim 9 , wherein upon lowering the robotic arm to the lowered position, the at least one coaxial needle pierces at least a portion of a seal member of the drug vial.

11 . The method of claim 9 , wherein upon lowering the robotic arm to the lowered position, an engaging surface of the at least one bracket member engages an engaging surface of the drug vial to limit axial movement thereof.

12 . The method of claim 9 , wherein the step of reconstituting the drug comprises allowing the reconstituting fluid to flow through an inner member to a dispensing opening formed on the inner member.

13 . The method of claim 9 , wherein the step of raising the at least one coaxial needle further comprises urging the at least one bracket member downwardly towards the drug vial.

14 . A system comprising:
a drug product vial containing a drug product, the drug product vial including a seal member to retain the drug product within the drug product vial; a robotic arm adapted to move between a plurality of positions; at least one bracket member operably coupled with the robotic arm, the at least one bracket member including a mounting region, a support surface, an upper surface, and a throughbore extending through the support surface and the upper surface; at least one coaxial needle operably coupled with the robotic arm and being at least partially disposed between the throughbore of the at least one bracket member and movable relative thereto, the at least one coaxial needle including a first end, a second end operably coupled with the robotic arm, an outer member, an inner member at least partially disposed within the outer member, a piercing tip positioned at the first end, and at least one venting hole disposed on the outer member; wherein upon moving the robotic arm to a lowered position, the piercing tip of the at least one coaxial needle is adapted to pierce at least a portion of the seal member of the drug product vial and the support surface of the at least one bracket member is adapted to be positioned adjacent to the seal member of the drug product vial.

15 . The system of claim 14 , the at least one coaxial needle further comprising a dispensing opening positioned at or near the first end, wherein upon moving the robotic arm to the lowered position, a fluid flows through the dispensing opening and into the drug product vial.

16 . The system of claim 14 , wherein upon moving the robotic arm to the lowered position, the at least one venting hole is adapted to be positioned at a height above a height of the drug product within the drug product vial.

17 . The system of claim 16 , further comprising a second venting hole positioned at or near the second end of the at least one coaxial needle.

18 . The system of claim 14 , wherein the at least one coaxial needle is adapted to be movable relative to the at least one bracket member such that upon raising the robotic arm, the at least one coaxial needle may move to a raised position while the support surface of the at least one bracket member remains engaged with the seal member of the drug vial.

19 . The system of claim 18 , further comprising an urging member adapted to exert an urging force on the at least one bracket member.

Assignees

• Amgen Inc

Inventors

• Umstead Russell Blake
• Johnson Michael A

Classifications

• A61J1/201 Primary

  having one piercing end · CPC title

• A61J1/2068

  Venting means · CPC title

• B01J19/0046

  Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays (synthesis methods per se C40B50/00) · CPC title

• B01J2219/00011

  Laboratory-scale plants · CPC title

• B01J2219/00373

  Hollow needles · CPC title