Biodegradable radiopaque microsphere

Patent metadata

Field	Value
Publication number	US-2024058479-A1
Application number	US-202318451174-A
Country	US
Kind code	A1
Filing date	Aug 17, 2023
Priority date	Aug 19, 2022
Publication date	Feb 22, 2024
Grant date	—

Abstract

A microsphere includes a radiopaque material, and a biodegradable material such that the microsphere can be detected using medical imaging and biodegrade after being administered to a patient.

First claim

What is claimed is:

1 . A microsphere comprising:
a radiopaque material, and a biodegradable material.

2 . The microsphere of claim 1 , wherein the radiopaque material is a nanoparticle.

3 . The microsphere of claim 1 , wherein the biodegradable material is chemically bound to the radiopaque material.

4 . The microsphere of claim 1 , wherein the radiopaque material is encapsulated by the biodegradable material.

5 . The microsphere of claim 1 , wherein the biodegradable material is coated by the radiopaque material.

6 . The microsphere of claim 1 , wherein the biodegradable material includes at least one of gelatin, alginate, chitosan, hyaluronic acid, collagen, cellulose, fibrinogen, fibrin, silk, elastin, hydroxyapatite, decellularized matrix, heparin, agarose, natural polysaccharides, albumin, gelatin methacrylate, triacyl gelatin, and hyaluronic acid methacrylate.

7 . The microsphere of claim 1 , wherein the biodegradable material includes as least one of poly(L-lactide) (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyurethane (PU), and polyvinyl alcohol (PVA).

8 . The microsphere of claim 1 , wherein the radiopaque material includes at least one of tantalum, gold, barium, strontium, gallium or iodine which may be in the form of pure metals, metal oxides, alloys, compounds, or any other suitable chemical formulation.

9 . A method of making a microsphere comprising linking a biodegradable material with a radiopaque material.

10 . A method of making a microsphere comprising encapsulating a radiopaque material with a biodegradable material.

11 . A method of making a microsphere comprising coating a biodegradable material with a radiopaque material.

12 . A method of making microspheres comprising:
providing a radiopaque material; combining the radiopaque material with a biodegradable material to define biodegradable radiopaque microspheres; and finish processing the biodegradable radiopaque microspheres.

13 . The method of claim 12 , wherein the radiopaque material is provided by synthesizing radiopaque nanoparticles through addition of a surfactant to a raw radiopaque material.

14 . The method of claim 12 , wherein the radiopaque material is provided by creating a radiopaque material and a biodegradable linker complex.

15 . The method of claim 14 , wherein the linker complex includes at least one of an amine, a carboxyl group, a peptide, a protein or functional polymer, and is biodegradable.

16 . The method of claim 12 , wherein the radiopaque material is provided as a metal-organic complex.

17 . The method of claim 12 , wherein the finish processing includes obtaining biodegradable radiopaque microspheres of uniform size distribution and target properties.

Assignees

• Varian Med Sys Inc

Inventors

• Bejleri Donald
• Jackson Jr Theodore Ronald

Classifications

• A61K49/04 Primary

  X-ray contrast preparations · CPC title

• A61B2090/3966

  Radiopaque markers visible in an X-ray image · CPC title

• A61K49/0419 Primary

  Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer · CPC title