Systems and methods for personalized cardiovascular analyses

Patent metadata

Field	Value
Publication number	US-2024055120-A1
Application number	US-202318383185-A
Country	US
Kind code	A1
Filing date	Oct 24, 2023
Priority date	Dec 20, 2019
Publication date	Feb 15, 2024
Grant date	—

Abstract

Systems and methods for performing personalized cardiovascular analyses are provided. A method includes building, using a modeling and simulation computing device, a patient-specific model, storing, using the modeling and simulation computing device, the patient-specific model in a database, receiving, at the modeling and simulation computing device, remote monitoring data from at least one remote monitoring data source, and receiving, at the modeling and simulation computing device, clinical data from at least one clinical data source. The method further includes updating, using the modeling and simulation computing device, the patient-specific model using the remote monitoring data and the clinical data, performing, using the modeling and simulation computing device, at least one simulation on the updated patient-specific model, and outputting, from the modeling and simulation computing device, at least one output based on the at least one simulation.

First claim

1 - 20 . (canceled)

21 . A computer-implemented method for performing personalized cardiovascular analyses, the method comprising:
receiving, at a modeling and simulation computing device, remote monitoring data from at least one remote monitoring data source, the remote monitoring data including at least actual hemodynamic data for a particular patient; updating, using the modeling and simulation computing device, a patient-specific model using the remote monitoring data, the patient specific model representing a circulatory system of the particular patient, wherein updating the patient-specific model comprises varying parameters of the patient-specific model until the patient-specific model replicates the actual hemodynamic data for the particular patient; performing, using the modeling and simulation computing device, at least one simulation on the updated patient-specific model to simulate operation of a ventricular assist device in the particular patient, wherein the at least one simulation includes simulating operation of the ventricular assist device in the particular patient while adjusting at least one of a pulse type, a medication, and a fluid volume; analyzing, using the modeling and simulation computing device, the updated patient-specific model to generate an adjusted operating parameters for the ventricular assist device; and controlling operation of an implanted device by transmitting a control signal including the adjusted operating parameter to the implanted device, the control signal causing the implanted device to adjust operation and begin operating at the adjusted operating parameter.

22 . The method of claim 21 , further comprising displaying a recommendation including the adjusted operating parameter.

23 . The method of claim 21 , further comprising building the patient-specific model using the modeling and simulation computing device.

24 . The method of claim 23 , wherein building the patient-specific model comprises:
generating a database including a plurality of anonymized patient models; and selecting one of the plurality of anonymized patient models as the patient-specific model.

25 . The method of claim 21 , further comprising:
receiving, at the modeling and simulation computing device, clinical data from at least one clinical data source; and updating the patient specific model using the clinical data.

26 . The method of claim 21 , wherein analyzing the updated patient-specific model comprises analyzing the updated patient-specific model using machine learning.

27 . A computing device for performing personalized cardiovascular analyses, the computing device comprising:
a memory device; and a processor communicatively coupled to the memory device, the processor configured to:
receive remote monitoring data from at least one remote monitoring data source, the remote monitoring data including at least actual hemodynamic data for a particular patient;
update a patient-specific model using the remote monitoring data, the patient specific model representing a circulatory system of the particular patient, wherein to update the patient-specific model, the processor is configured to vary parameters of the patient-specific model until the patient-specific model replicates the actual hemodynamic data for the particular patient;
perform at least one simulation on the updated patient-specific model to simulate operation of a ventricular assist device in the particular patient, wherein the at least one simulation includes simulating operation of the ventricular assist device in the particular patient while adjusting at least one of a pulse type, a medication, and a fluid volume;
analyze the updated patient-specific model using machine learning to generate an adjusted operating parameters for the ventricular assist device; and
control operation of an implanted device by transmitting a control signal including the adjusted operating parameter to the implanted device, the control signal causing the implanted device to adjust operation and begin operating at the adjusted operating parameter.

28 . The computing device of claim 27 , wherein the processor is further configured to output a recommendation including the adjusted operating parameter.

29 . The computing device of claim 27 , wherein the processor is further configured to build the patient-specific model.

30 . The computing device of claim 29 , wherein to build the patient-specific model, the processor is configured to
generate a database including a plurality of anonymized patient models; and select one of the plurality of anonymized patient models as the patient-specific model.

31 . The computing device of claim 27 , wherein the processor is further configured to:
receive clinical data from at least one clinical data source; and update the patient specific model using the clinical data.

32 . The computing device of claim 27 , wherein the processor is further configured to analyze the updated patient-specific model using machine learning.

33 . Non-transitory computer-readable media having computer-executable instructions thereon, wherein when executed by a processor of a computing device, cause the processor of the computing device to:
receive remote monitoring data from at least one remote monitoring data source, the remote monitoring data including at least actual hemodynamic data for a particular patient; update a patient-specific model using the remote monitoring data, the patient specific model representing a circulatory system of the particular patient, wherein to update the patient-specific model, the instructions cause the process to vary parameters of the patient-specific model until the patient-specific model replicates the actual hemodynamic data for the particular patient; perform at least one simulation on the updated patient-specific model to simulate operation of a ventricular assist device in the particular patient, wherein the at least one simulation includes simulating operation of the ventricular assist device in the particular patient while adjusting at least one of a pulse type, a medication, and a fluid volume; analyze the updated patient-specific model to generate an adjusted operating parameter for the ventricular assist device; and control operation of an implanted device by transmitting a control signal including the adjusted operating parameter to the implanted device, the control signal causing the implanted device to adjust operation and begin operating at the adjusted operating parameter.

34 . The non-transitory computer-readable media of claim 33 , wherein the instructions further cause the processor to output a recommendation including the adjusted operating parameter.

35 . The non-transitory computer-readable media of claim 33 , wherein the instructions further cause the processor to build the patient-specific model.

36 . The non-transitory computer-readable media of claim 35 , wherein to build the patient-specific model the instructions further cause the processor to:
generate a database including a plurality of anonymized patient models; and select one of the plurality of anonymized patient models as the patient-specific model.

37 . The non-transitory computer-readable media of claim 33 , wherein the instructions further cause the processor to:
receive clinical data from at least one clinical data source; and update the patient specific model using the clinical data.

38 . The non-transitory computer-readable media of claim 33 , wherein the instructions further cause the proc

Assignees

• Tc1 Llc

Inventors

• Lee Eric
• Harjes Daniel I

Classifications

• G16H50/00 Primary

  ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics · CPC title

• G16H40/67

  for remote operation · CPC title

• G16H10/60

  for patient-specific data, e.g. for electronic patient records · CPC title

• G16H50/20 Primary

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title

• G16H70/20

  relating to practices or guidelines · CPC title