Stents for use in the interventional treatment of vascular disorders and vascular surgery

Patent metadata

Field	Value
Publication number	US-2024050247-A1
Application number	US-202118267810-A
Country	US
Kind code	A1
Filing date	Dec 14, 2021
Priority date	Dec 17, 2020
Publication date	Feb 15, 2024
Grant date	—

Abstract

In the stent for use in the interventional treatment of vascular diseases and in vascular surgery, there is a tubular support structure formed with struts made of a first bioresorbable metallic material that are joined to one another at selective points. The surface of the struts is fully covered by a coating made with a second bioresorbable metallic material. The second metallic material has a lower dissolution rate in the implanted state under physiological conditions in the course of bioresorption, and has a more positive electrode potential compared to the first metallic material.

First claim

1 - 16 . (canceled)

17 . A stent for use in the interventional treatment of vascular diseases and vascular surgery, in which a tubular support structure, which is formed of struts that are connected to one another at selective points and made of a first bioresorbable metallic material, is formed and
a completely covering coating, which is produced with a second bioresorbable metallic material, is created on the surface of the struts, the second metallic material having a lower dissolution rate under physiological conditions when implanted during bioresorption and a more positive electrode potential compared to the first metallic material.

18 . The stent according to claim 17 , wherein the surface of the struts, which are made of the first bioresorbable metallic material, is partially or completely provided with a surface structuring, which is produced with elevations and depressions.

19 . The stent according to claim 18 , wherein the surface of the struts, which are made of the first bioresorbable metallic material, is increased with a surface structuring by a factor of 1.1 to 10 compared to an electropolished surface of the struts.

20 . The stent according to claim 17 , wherein the surface structuring is created periodically and/or using grooves, troughs or valleys and/or elevations, using rings and/or peaks.

21 . The stent according to claim 17 , wherein the first metallic material is tungsten, molybdenum, or a base alloy of one of these two metals, at least one metal contained in a molybdenum base alloy being selected from W, Re, Nb, Ta and Mn; or at least one metal contained in the tungsten base alloy being selected from Mo, Re, Nb, Ta and Mn.

22 . The stent according to claim 17 , wherein the first metallic material is made of a molybdenum base alloy which contains at least 50 at % Mo or a tungsten base alloy which contains at least 50 at % tungsten.

23 . The stent according to claim 22 , wherein a molybdenum alloy is produced with at least one alloying element which is selected from W, Ta, Nb, Re and Mn and comprises the alloying element(s) W, Ta and/or Nb in a content of greater than 0 at % to less than 50 at % and/or the alloying element Re in a content of greater than 0 at % to 42 at % and/or the alloying element Mn in a content of greater than 0 at % to 36 at %.

24 . The stent according to claim 22 , wherein a tungsten alloy is produced with at least one alloying element which is selected from Mo, Ta, Nb, Re and Mn and comprises the alloying element(s) Mo, Ta and/or Nb in a content of greater than 0 at % to less than 50 at % and/or the alloying element Re in a content of greater than 0 at % to 37 at % and/or the alloying element manganese in a content of greater than 0 at % to 20 at %.

25 . The stent according to claim 17 , wherein the second metallic material is made of rhenium or a base alloy of rhenium, molybdenum or tungsten, at least one metal contained in the rhenium base alloy being selected from W and Mo or the metal contained in a molybdenum or tungsten base alloy being Re.

26 . The stent according to claim 25 , wherein a rhenium base alloy having a content of greater than 0 at % to 14 at % of Mo or a content of greater than 0 at % to 20 at % of W is produced.

27 . The stent according to claim 26 , wherein a molybdenum base alloy having a Re content of greater than 0 at % to 42 at % is produced, the content of Re being greater than the Re content in the first metallic material when this first material ( 4 ) is a MoRe alloy.

28 . The stent according to claim 26 , wherein a tungsten base alloy having a Re content of greater than 0 at % to 37 at % is produced, the content of Re being greater than the Re content in the first metallic material when this first material ( 4 ) is a WRe alloy.

29 . The stent according to claim 17 , wherein the second metallic material is pure molybdenum, if the first metallic material is produced with tungsten or with a tungsten base alloy which contains Mo, Ta, Nb and/or Mn.

30 . The stent according to claim 17 , wherein the sum of the volume of the second metallic material is less than the volume of the first metallic material ( 4 ) that is used to produce the stent struts.

31 . The stent according to claim 17 , wherein the coating is created with a layer thickness in the range of 1 nm to 1000 nm taking into consideration the dissolution rate and the time required for the restoration of the vessel wall.

32 . The stent according to claim 17 , wherein the coating is created with a layer thickness in the range of 1 nm to 50 nm taking into consideration the dissolution rate and the time required for the restoration of the vessel wall.

33 . The stent according to claim 17 , wherein the layer thickness of the coating on the surface of the struts varies.

Assignees

• Fraunhofer Ges Forschung

Inventors

• Redlich Christian
• Pohle Georg
• Quadbeck Peter

Classifications

• A61F2/91 Primary

  made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes · CPC title

• A61L31/022 Primary

  Metals or alloys · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61L31/088

  Other specific inorganic materials not covered by A61L31/084 or A61L31/086 · CPC title

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title