Mass spectrometer and mass spectrometry method

Patent metadata

Field	Value
Publication number	US-2024038524-A1
Application number	US-202318213974-A
Country	US
Kind code	A1
Filing date	Jun 26, 2023
Priority date	Jul 26, 2022
Publication date	Feb 1, 2024
Grant date	—

Abstract

The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.

First claim

What is claimed is:

1 . A mass spectrometer comprising:
a linear ion trap section that traps ions emitted from an ion source; and an analyzer that analyzes the ions ejected from the linear ion trap section, wherein the linear ion trap section includes a multipole rod electrode that forms a multipole electric field, the multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section, in the multipole rod electrode, a first radio frequency voltage in opposite phase is applied to adjacent rod electrodes, an electrostatic voltage having a same amplitude and a second radio frequency voltage are applied to the segments having a same position in the direction of the center axis, the second radio frequency voltage being different from the first radio frequency voltage and being in phase, the electrostatic voltage is applied to the plurality of segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section, and the second radio frequency voltage is applied to the plurality of segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.

2 . The mass spectrometer according to claim 1 , wherein
the linear ion trap section traps the ions in a region formed by the multipole rod electrode, in descending order of mass to charge ratio m/z.

3 . The mass spectrometer according to claim 2 , wherein
the linear ion trap section traps the ions at a position indicating a minimum of combined characteristics obtained by combining characteristics of the electrostatic voltage with respect to the position in the direction of the center axis and characteristics of the second radio frequency voltage with respect to the position in the direction of the center axis.

4 . The mass spectrometer according to claim 2 , wherein
the linear ion trap section scans a gradient of the electrostatic voltage from high to low, to cause the ions to be mass selectively ejected from the linear ion trap section to the analyzer.

5 . The mass spectrometer according to claim 2 , wherein
the linear ion trap section scans a gradient of the second radio frequency voltage from high to low, to cause the ions to be mass selectively ejected from the linear ion trap section to the analyzer.

6 . The mass spectrometer according to claim 1 , further comprising a plurality of the linear ion trap sections connected in parallel, wherein
the adjacent linear ion trap sections share some of the multipole rod electrodes, and the ions are dispersed in a plurality of regions formed by the plurality of linear ion trap sections, and the dispersed ions are trapped.

7 . A mass spectrometry method comprising:
emitting ions from an ion source; applying a first radio frequency voltage in opposite phase to adjacent rod electrodes in a multipole rod electrode that forms a multipole electric field in a linear ion trap section, the multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section; applying an electrostatic voltage having a same amplitude and a second radio frequency voltage to the segments having a same position in the direction of the center axis, the second radio frequency voltage being different from the first radio frequency voltage and being in phase; and ejecting the ions from the linear ion trap section to an analyzer, wherein the electrostatic voltage is applied to the plurality of segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section, and the second radio frequency voltage is applied to the plurality of segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.

8 . The mass spectrometry method according to claim 7 , further comprising trapping, in the linear ion trap section, the ions in a region formed by the multipole rod electrode, in descending order of mass to charge ratio m/z.

9 . The mass spectrometry method according to claim 8 , wherein
the linear ion trap section traps the ions at a position indicating a minimum of combined characteristics obtained by combining characteristics of the electrostatic voltage with respect to the position in the direction of the center axis and characteristics of the second radio frequency voltage with respect to the position in the direction of the center axis.

10 . The mass spectrometry method according to claim 8 , further comprising scanning, in the linear ion trap section, a gradient of the electrostatic voltage from high to low, to mass selectively eject the ions from the linear ion trap section to the analyzer.

11 . The mass spectrometry method according to claim 8 , further comprising scanning, in the linear ion trap section, a gradient of the second radio frequency voltage from high to low, to mass selectively eject the ions from the linear ion trap section to the analyzer.

12 . The mass spectrometry method according to claim 7 , further comprising:
providing a plurality of linear ion trap sections which are connected in parallel wherein adjacent linear ion trap sections of the plurality of linear ion trap sections share some of the multipole rod electrodes, and dispersing the ions in a plurality of regions formed by the plurality of linear ion trap sections to trap the dispersed ions.

Assignees

• Hitachi Ltd

Inventors

• Sugiyama Masuyuki
• Kumano Shun
• Nojima Akihiro

Classifications

• H01J49/4225 Primary

  Multipole linear ion traps, e.g. quadrupoles, hexapoles · CPC title

• H01J49/065

  having stacked electrodes, e.g. ring stack, plate stack · CPC title

• H01J49/429

  Scanning an electric parameter, e.g. voltage amplitude or frequency · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/004 Primary

  Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn · CPC title