MXene Sorbent For Removal Of Small Molecules From Dialysate

Patent metadata

Field	Value
Publication number	US-2024017239-A1
Application number	US-202318353257-A
Country	US
Kind code	A1
Filing date	Jul 17, 2023
Priority date	Aug 1, 2017
Publication date	Jan 18, 2024
Grant date	—

Abstract

The present disclosure is directed to methods for scrubbing low levels of urea from aqueous solutions such as a dialysate from dialysis, and including blood and blood products, and devices capable of employing these methods.

First claim

1 . A cartridge for removing urea from an initial aqueous solution of urea, comprising:
A MXene composition through which the initial aqueous solution is directed to pass,
the cartridge adapted to allow the initial aqueous urea solution to contact the MXene composition contained in the cartridge.

2 . The cartridge of claim 1 , wherein the cartridge is exchangeable.

3 . The cartridge of claim 1 , wherein the cartridge comprises a plurality of channels and wherein the MXene composition is present as a coating on the channels.

4 . The cartridge of claim 1 , wherein the MXene composition is comprised in a permeable bed.

5 . The cartridge of claim 1 , wherein the MXene composition is present in bulk form.

6 . The cartridge of claim 1 , wherein the MXene composition comprises a composition comprising at least one layer having first and second surfaces, each layer described by a formula M n+1 X n T x , such that
each X is position within an octahedral array of M, wherein M is at least on Group IIIB, IVB, VB, or VIB metal, wherein each X is C, N, or a combination thereof, n=1, 2, or 3; and wherein T x represents surface termination groups.

7 . The cartridge of claim 6 , wherein a surface termination group comprises alkoxide, carboxylate, halide, hydroxide, hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

8 . The cartridge of claim 6 , wherein M is at least one group IVB, Group VB, or Group VIB metal.

9 . The cartridge of claim 6 , wherein M is Ti, Mo, Nb, V or Ta, or a combination thereof.

10 . The cartridge of claim 6 , wherein M n+1 X n is Ti 2 C, Mo 2 Ti 2 C, Mo 2 TiC 2 , Ti 3 C 2 , or a combination thereof.

11 . The cartridge of claim 1 , wherein the MXene composition comprises a composition comprising at least one layer having first and second surfaces, each layer comprising:
a. a substantially two-dimensional array of crystal cells, b. each crystal cell having an empirical formula of M′ 2 M″ n X n+1 , such that each X is positioned within an octahedral array of M′ and M″, and where M″ 2 are present as individual two-dimensional array of atoms intercalated between a pair of two-dimensional arrays of M′ atoms, c. wherein M′ and M″ are different Group IIIB, IVB, VB, or VIB metals, d. wherein each X is C, N, or a combination thereof; and e. n=1 or 2.

12 . The cartridge of claim 11 , wherein n is 1, M′ is Mo, and M″ is Nb, Ta, Ti, or V,
or a combination thereof.

13 . The cartridge of claim 11 , wherein n is 2, M′ is Mo, Ti, V, or a combination thereof, and M″ is Cr, Nb, Ta, Ti, or V, or a combination thereof.

14 . The cartridge of claim 11 , wherein M′ 2 M″ n X n+1 comprises Mo 2 TiC 2 , Mo 2 VC 2 , Mo 2 TaC 2 , Mo 2 NbC 2 , Mo 2 Ti 2 C 3 , Cr 2 TiC 2 , Cr 2 VC 2 , Cr 2 TaC 2 , Cr 2 NbC 2 , Ti 2 NbC 2 , Ti 2 TaC 2 , V 2 TaC 2 , Mo 2 Ti 2 C 3 , Mo 2 V 2 C 3 , Mo 2 Nb 2 C 3 , Mo 2 Ta 2 C 3 , Cr 2 Ti 2 C 3 , Cr 2 V 2 C 3 , Cr 2 Nb 2 C 3 , Cr 2 Ta 2 C 3 , Nb 2 Ta 2 C 3 , Ti 2 Nb 2 C 3 , Ti 2 Ta 2 C 3 , V 2 Ta 2 C 3 , V 2 Nb 2 C 3 , or V 2 Ti 2 C 3 , or a nitride or carbonitride analog thereof.

15 . The cartridge of claim 11 , wherein the MXene composition comprises a plurality of stacked layers.

16 . The cartridge of claim 11 , wherein at least one of said surfaces of each layer has surface terminations comprising alkoxide, carboxylate, halide, hydroxide, hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

17 . A method, comprising contacting an initial aqueous urea solution to a cartridge according to claim 1 , the contacting being at ambient or near ambient temperatures and under such conditions that the urea is reduced from an initial concentration in the initial aqueous urea solution to a final concentration in a final solution, wherein the initial concentration of urea in the initial aqueous solution is in a range of from 10 mmol/L to 1000 mmol/L, or is initially in a concentration range from 15 to 40 mg/dL mg/dL, and the final concentration is at least 10% less than the initial concentration, and wherein the aqueous solution is or comprises blood or a blood product and the ambient or near ambient temperatures and conditions used do not compromise the utility of the blood or blood product for later use by a human patient.

18 . The method of claim 17 , wherein the final concentration is at least 50% less than the initial concentration.

19 . The method of claim 17 , wherein the contacting is for less than about 5 minutes.

20 . The method of claim 17 , wherein adsorption of the urea to the MXene attains equilibrium within 5 minutes.

Assignees

• Univ Drexel
• Univ Of Brighton

Inventors

• Gogotsi Yury
• Mikhalovsky Sergey
• Sandeman Susan R
• Anasori Babak
• Meng Fayan

Classifications

• B01J20/0211 Primary

  Compounds of Ti, Zr, Hf · CPC title

• A61M1/1656

  Apparatus for preparing dialysates · CPC title

• B01D15/08

  Selective adsorption, e.g. chromatography · CPC title

• B01J20/0218 Primary

  Compounds of Cr, Mo, W · CPC title

• B01J20/0274

  characterised by the type of anion · CPC title