Low energy multimodal stimulation

Patent metadata

Field	Value
Publication number	US-2023381522-A1
Application number	US-202118248219-A
Country	US
Kind code	A1
Filing date	Oct 8, 2021
Priority date	Oct 8, 2020
Publication date	Nov 30, 2023
Grant date	—

Abstract

This disclosure is directed to devices, systems, and techniques for delivering various stimulation patterns. In some examples, a method includes generating, by stimulation generation circuitry, a first train of electrical stimulation pulses at a first frequency to a first target tissue, and generating, by the stimulation generation circuitry, a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second train of electrical stimulation pulses, and wherein the first frequency is greater than the second frequency.

First claim

1 . A system comprising:
stimulation generation circuitry configured to generate and deliver electrical stimulation therapy; and processing circuitry configured to control the stimulation generation circuitry to:
generate a first train of electrical stimulation pulses at a first frequency to a first target tissue; and
generate a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second train of electrical stimulation pulses, and wherein the first frequency is greater than the second frequency.

2 . The system of claim 1 , wherein the processing circuitry is configured to control the stimulation generation circuitry to generate a third train of electrical stimulation pulses at a third frequency to the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses, at least some of the electrical stimulation pulses of the second train of electrical stimulation pulses, and at least some of the electrical stimulation pulses of the third train of electrical stimulation pulses are all interleaved together.

3 . The system of claim 2 , wherein the processing circuitry is configured to control the stimulation generation circuitry to change an order of pulses of the first train of electrical stimulation pulses with pulses of the third train of electrical stimulation pulses over time to adjust a pulse pattern created by interleaving the at least some of the electrical stimulation pulses of the first train of electrical stimulation pulses with the at least some of the electrical stimulation pulses of the third train of electrical stimulation pulses.

4 . The system of claim 2 , wherein the first train of electrical stimulation pulses and the third train of electrical stimulation pulses are generated together with an average frequency greater than the second frequency of the second train of electrical stimulation pulses.

5 . The system of claim 4 , wherein the third frequency one of equal to the second frequency or greater than the second frequency.

6 . The system of claim 3 , wherein the average frequency is selected from a frequency range from approximately 150 Hz to approximately 600 Hz.

7 . The system of claim 1 , wherein the stimulation generation circuitry is configured to generate electrical stimulation pulses in a repeatable series of slots, the repeatable series of slots being repeatable over time for generating the first train of electrical stimulation pulses and the second train of electrical stimulation pulses, and wherein:
the processing circuitry is configured to control the stimulation generation circuitry to generate the first train of electrical stimulation pulses by at least generating one pulse for a first slot of at least some of the repeatable series of slots that achieves the first frequency, and the processing circuitry is configured to control the stimulation generation circuitry to generate the second train of electrical stimulation pulses by at least generating one pulse for a second slot of at least some of the repeatable series of slots that achieves the second frequency.

8 . The system of claim 1 , wherein the second frequency is selected from a frequency range from approximately 40 Hz to approximately 60 Hz.

9 . The system of claim 1 , wherein the processing circuitry is configured to control the stimulation generation circuitry to cycle between a first mode of a first period of time and a second mode of a second period of time, wherein the first mode comprises generating the first train of electrical stimulation pulses at least partially interleaved with the second train of electrical stimulation pulses, and wherein the second mode comprises withholding generation of the first train of electrical stimulation pulses and the second train of electrical stimulation pulses.

10 . The system of claim 9 , wherein a ratio of the first period to the second period of time is selected in a range from approximately 1:1 to 1:3.

11 . The system of claim 9 , wherein the first period of time is selected from a range from approximately 1 minute to approximately 30 minutes.

12 . The system of claim 9 , wherein the first period of time is selected from a range from approximately 5 minute to approximately 15 minutes.

13 . The system of claim 1 , wherein an amplitude of at least one of pulses of the first train of electrical stimulation pulses or pulses of the second train of electrical stimulation is below at least one of a perception threshold or a sensory threshold of a patient.

14 . The system of claim 1 , wherein the first target tissue comprises glial cells, and wherein the second target tissue comprises neurons.

15 . The system of claim 1 , further comprising an implantable medical device comprising the processing circuitry and the stimulation generation circuitry.

16 . A method comprising:
generating, by stimulation generation circuitry, a first train of electrical stimulation pulses at a first frequency to a first target tissue; and generating, by the stimulation generation circuitry, a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second train of electrical stimulation pulses, and wherein the first frequency is greater than the second frequency.

17 . The method of claim 16 , further comprising generating, by stimulation generation circuitry, a third train of electrical stimulation pulses at a third frequency to the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses, at least some of the electrical stimulation pulses of the second train of electrical stimulation pulses, and at least some of the electrical stimulation pulses of the third train of electrical stimulation pulses are all interleaved together.

18 . The method of claim 17 , further comprising changing an order of pulses of the first train of electrical stimulation pulses with pulses of the third train of electrical stimulation pulses over time to adjust a pulse pattern created by interleaving the at least some of the electrical stimulation pulses of the first train of electrical stimulation pulses with the at least some of the electrical stimulation pulses of the third train of electrical stimulation pulses, wherein:
the first train of electrical stimulation pulses and the third train of electrical stimulation pulses are generated together with an average frequency greater than the second frequency of the second train of electrical stimulation pulses, the third frequency one of equal to the second frequency or greater than the second frequency, and the average frequency is selected from a frequency range from approximately 150 Hz to approximately 600 Hz.

19 . The method of claim 16 , further comprising cycling between a first mode of a first period of time and a second mode of a second period of time, wherein the first mode comprises generating the first train of electrical stimulation pulses at least partially interleaved with the second train of electrical stimulation pulses, and wherein the second mode co

Assignees

• Medtronic Inc

Inventors

• Cleland Andrew J
• Kelley Brooke G
• Hincapie Juan G
• Sharma Vinod
• Kramer Jeffery M

Classifications

• A61N1/36178 Primary

  Burst or pulse train parameters · CPC title

• A61N1/36071

  Pain · CPC title

• A61N1/36171

  Frequency · CPC title

• A61N1/3606 Primary

  adapted for a particular treatment · CPC title

• A61N1/36062

  Spinal stimulation · CPC title