Systems for treating pulmonary infections

Patent metadata

Field	Value
Publication number	US-2023338405-A1
Application number	US-202318142532-A
Country	US
Kind code	A1
Filing date	May 2, 2023
Priority date	May 21, 2012
Publication date	Oct 26, 2023
Grant date	—

Abstract

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

First claim

1 - 31 . (canceled)

32 . A method for treating or providing prophylaxis against a pulmonary infection in a patient, the method comprising:
aerosolizing a pharmaceutical formulation comprising a liposomal complexed aminoglycoside, wherein the pharmaceutical formulation is an aqueous dispersion and is aerosolized at a rate greater than about 0.53 gram per minute, and administering the aerosolized pharmaceutical formulation to the lungs of the patient; wherein the aerosolized pharmaceutical formulation comprises a mixture of free aminoglycoside and liposomal complexed aminoglycoside, wherein the lipid component of the liposome consists of electrically neutral lipids, and the FPF of the aerosol is greater than or equal to about 64%, as measured by the ACI, or greater than or equal to about 51%, as measured by the NGI.

33 - 146 . (canceled)

Assignees

• Insmed Inc

Inventors

• Perkins Walter
• Malinin Vladimir
• Li Xingong
• Miller Brian
• Seidel Dominique
• Holzmann Philipp
• Schulz Harald
• Hahn Michael

Classifications

• B05B17/0646

  Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto · CPC title

• A61M15/00

  Inhalators {(drug delivery in endotracheal tubes A61M16/04)} · CPC title

• A61K31/7036 Primary

  having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61K9/0078

  for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions · CPC title