Methods and compositions for generating oligodendrocyte progenitor cells
US-2024158744-A1 · May 16, 2024 · US
Production method for microglia
US2023323295A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2023323295-A1 |
| Application number | US-202318176959-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 1, 2023 |
| Priority date | Mar 22, 2022 |
| Publication date | Oct 12, 2023 |
| Grant date | — |
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- Title
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Abstract
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There is provided a production method for microglia, including a step of introducing, into pluripotent stem cells, a nucleic acid including an open reading frame of a transcription factor that increases expression of a Complement C3 (C3) gene. In the production method, the transcription factor is selected from the group consisting of SPI1, CEBPA, PTAFR, FLI1, MEF2C, EGR2, RUNX1, TNF, CEBPB, IKZF1, KLF6, NFIC, ELF4, PAX8, PRDM1, MEF2A, and NR4A3.
First claim
Opening claim text (preview).
What is claimed is: 1 . A production method for microglia, comprising: introducing, into pluripotent stem cells, a nucleic acid including an open reading frame of a transcription factor that increases expression of a Complement C3 (C3) gene. 2 . The production method according to claim 1 , wherein the transcription factor is selected from the group consisting of SPI1, CEBPA, PTAFR, FLI1, MEF2C, EGR2, RUNXI, TNF, CEBPB, 1KZF1, KLF6, NFIC, ELF4, PAX8, PRDM1, MEF2A, and NR4A3. 3 . The production method according to claim 2 , wherein the transcription factor includes at least CEBPA. 4 . The production method according to claim 2 , wherein the transcription factor is two or more transcription factors including at least CEBPA. 5 . The production method according to claim 3 . wherein the transcription factor is two or more transcription factors including at least CEBPA.
Assignees
Inventors
Classifications
- C12N5/0622Primary
Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells · CPC title
Transcription factors · CPC title
from artificially induced pluripotent stem cells · CPC title
- C12N5/10Primary
Cells modified by introduction of foreign genetic material · CPC title
Cells of the nervous system · CPC title
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- What does patent US2023323295A1 cover?
- There is provided a production method for microglia, including a step of introducing, into pluripotent stem cells, a nucleic acid including an open reading frame of a transcription factor that increases expression of a Complement C3 (C3) gene. In the production method, the transcription factor is selected from the group consisting of SPI1, CEBPA, PTAFR, FLI1, MEF2C, EGR2, RUNX1, TNF, CEBPB, IKZ…
- Who is the assignee on this patent?
- Yumoto Masayuki, Kawashima Yudai, Watanabe Hikaru, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0622. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Oct 12 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).