Blood-filtering devices for use with clot treatment systems

Patent metadata

Field	Value
Publication number	US-2023310751-A1
Application number	US-202318192855-A
Country	US
Kind code	A1
Filing date	Mar 30, 2023
Priority date	Mar 31, 2022
Publication date	Oct 5, 2023
Grant date	—

Abstract

Disclosed herein are clot treatment systems with filtering syringes, and associated devices and methods. The filtering syringe can be coupled to a catheter subsystem insertable within a patient. The filtering syringe can aspirate material (e.g., clot material, blood, etc.) from a patient via the catheter subsystem. The filtering syringe can include a plunger assembly, and the plunger assembly can include one or more filters. Each of the filters can be configured to (i) allow at least a first portion of aspirated material (e.g., blood) to pass through at least one of the filters, and (ii) prevent at least a second portion of the aspirated material (e.g., clot material) from passing through at least one of the filters. In some embodiments, the filtering syringe is fluidly coupled to a filtered material subsystem that can fluidly couple the filtering syringe to the patient or another suitable fluid outflow location.

First claim

I/We claim:

1 . A filtering syringe for treatment of clot material from within a blood vessel of a patient, the filtering syringe comprising:
a barrel defining a chamber configured to receive at least a portion of the clot material and blood from the patient; and a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate to the first end portion, a port proximate to the second end portion, and a lumen therebetween and fluidly coupling the filter and the port; wherein at least the first end portion of the plunger assembly is insertable within the chamber and slidable relative to the barrel; and wherein the filter is configured to allow at least part of the blood received within the chamber to separate from the portion of the clot material and enter the lumen of the plunger assembly.

2 . The filtering syringe of claim 1 , further comprising a tip configured to fluidly couple the filtering syringe to a clot treatment system.

3 . The filtering syringe of claim 1 wherein the filter has a circular, annular, cylindrical, and/or pleated shape.

4 . The filtering syringe of claim 1 wherein the filter has a porosity between about 40 microns and about 200 microns.

5 . The filtering syringe of claim 1 wherein the filter includes at least one of a polyester, a polyamide, and/or a hemocompatible material.

6 . The filtering syringe of claim 1 wherein the filter is a first filter having a first porosity, the filtering syringe further comprising a second filter having a second porosity.

7 . The filtering syringe of claim 6 wherein the first porosity is different than the first porosity.

8 . The filtering syringe of claim 6 wherein the first porosity is the same as the second porosity.

9 . The filtering syringe of claim 6 wherein the second filter is positioned proximate the first end portion of the plunger assembly.

10 . The filtering syringe of claim 6 wherein the second filter is spaced apart from the first filter.

11 . The filtering syringe of claim 1 wherein the port includes a luer-activated valve.

12 . The filtering syringe of claim 1 wherein the first end portion of the plunger assembly is a distal end portion of the plunger assembly and the second end portion is a proximal end portion of the plunger assembly, wherein the filter is positioned proximally from the distal end portion.

13 . The filtering syringe of claim 1 wherein the chamber includes an inner surface, and wherein first end portion of the plunger assembly is radially spaced apart from chamber such that the barrel assembly and the plunger assembly at least partially define (i) a first chamber portion positioned on a first side of the first end portion of the plunger assembly, (ii) a second chamber portion positioned on a second side of the first end portion of the plunger assembly, the second side opposite the first side, and (iii) a gap fluidly coupling the first chamber portion and the second chamber portion.

14 . The filtering syringe of claim 13 wherein the filter is positioned in the second chamber portion, wherein the first chamber portion is configured to receive at least the portion of the clot material from the patient, wherein the gap is configured to at least partially prevent the portion of the clot material from entering the second chamber portion, and wherein the filter is configured to allow blood within the second chamber portion to enter the lumen.

15 . The filtering syringe of claim 1 wherein the first end portion of the plunger assembly is configured to at least partially prevent contact between the filter and the portion of the clot material.

16 . The filtering syringe of claim 1 wherein the plunger assembly defines a filter chamber configured to receive the filter, and wherein the first end portion of the plunger assembly includes one or more holes in fluid communication with the filter chamber.

17 . The filtering syringe of claim 16 wherein the filter is an annular filter defining a central space, and wherein individual ones of the one or more holes are positioned to direct at least a portion of the clot material and/or the blood received from the patient into the central space.

18 . A system for intravascular treatment of clot material from within a blood vessel of a human patient, the system comprising:
a catheter configured to be intravascularly positioned at a treatment site proximate to the clot material within the blood vessel; and a filtering syringe configured to generate negative pressure, wherein the filtering syringe includes—
a tip configured to be fluidly coupled to the catheter to receive at least a portion of the clot material and blood from within the blood vessel via the catheter, and
a filter assembly including one or more filters configured to filter the blood from the portion of the clot material.

19 . The system of claim 18 , further comprising a filtered material system fluidly coupled to the filtering syringe and configured to receive at least a portion of the filtered blood.

20 . The system of claim 19 , wherein the filtered material system includes a fluid drive component operable to drive flow of the filtered blood through at least part of the filtered material system.

21 . The system of claim 20 wherein the filtered material system includes at least one flow path, and wherein fluid drive component is operable to drive the flow of the filtered blood through the at least one flow path.

22 . The system of claim 21 wherein the at least one flow path is configured to direct fluid flow away from the filtering syringe.

23 . The system of claim 19 wherein the filtering syringe further includes a valve opposite the tip, wherein the filtered material system includes (i) a fluid control device fluidly coupled to the valve and (ii) tubing fluidly coupled to the fluid control device, and wherein the fluid control device is configured to at least partially prevent filtered blood within the tubing from entering the filtering syringe.

24 . A method for removing clot material from within a blood vessel of a human patient, the method comprising:
positioning a distal portion of a catheter proximate to the clot material within the blood vessel; coupling a filtering and pressure-generating syringe to the catheter via a fluid control device, wherein (i) opening of the fluid control device fluidly connects the filtering and pressure-generating syringe to the catheter, and (ii) closing the fluid control device fluidly disconnects the filtering and pressure-generating syringe from the catheter; activating the syringe to generate a vacuum while the fluid control device is closed; opening the fluid control device to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material into the catheter; and filtering blood from the portion of the clot material via a filter of the syringe.

25 . The method of claim 24 wherein filtering the blood includes moving a plunger of the syringe to cause the filter to move toward the portion of the clot material.

26 . The method of claim 24 wherein filtering the blood includes actuating a fluid drive component of a filtered material system to cause the blood to flow through the filter proximally toward the fluid drive component.

27 . A filtering syringe for removing t

Assignees

• Inari Medical Inc

Inventors

• Merritt Benjamin Edward
• Zikry Christopher Andrew
• Thress John Coleman
• Ozenne Parker
• Mcconnell Steven

Classifications

• A61M1/79

  Filters for solid matter (specially adapted for dental use A61C17/065) · CPC title

• A61B17/3207

  Atherectomy devices {working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions (A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016)} · CPC title

• A61B2217/005

  with suction drainage system · CPC title

• A61B17/22

  Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for · CPC title

• A61M5/3145 Primary

  Filters incorporated in syringes · CPC title