Pipette tip extension

Patent metadata

Field	Value
Publication number	US-2023302442-A1
Application number	US-202218090579-A
Country	US
Kind code	A1
Filing date	Dec 29, 2022
Priority date	Mar 24, 2022
Publication date	Sep 28, 2023
Grant date	—

Abstract

A pipette tip extension attachable to a pipette tip with the pipette tip extension having a proximal end, a distal end, and exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall having an outer side and inner side and forming at the proximal end a reception aperture for inserting a pipette tip, and at a distal end a dispense aperture. An inner cavity is enclosed by the inner side of the exterior wall and one or more distance elements connected to the inner side of the exterior wall. The distance element(s) being configured to position a pipette tip within the inner cavity and to establish fluid uptake area adjacent the inner side of the exterior wall with the fluid uptake area extending from the dispense aperture towards the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture.

First claim

What is claimed is:

1 . A pipette tip extension ( 1 ) attachable to a pipette tip ( 20 ), the pipette tip extension ( 1 ) comprising:
a proximal end ( 2 ), a distal end ( 3 ), and an exterior wall ( 4 ) extending between the proximal end ( 2 ) and the distal end ( 3 ), the exterior wall ( 4 ) having an outer side ( 5 ) and an inner side ( 6 ) and forming at the proximal end ( 2 ) a reception aperture ( 7 ) for inserting a pipette tip ( 14 ), and at the distal end a dispense aperture ( 8 ), an inner cavity ( 9 ) enclosed by the inner side ( 6 ) of the exterior wall ( 4 ), one or more distance elements ( 10 ) connected to the inner side ( 6 ) of the exterior wall ( 4 ), the distance element(s) ( 10 ) being configured to position a pipette tip ( 20 ) within the inner cavity ( 9 ) and to establish a fluid uptake area ( 11 ) adjacent to the inner side ( 6 ) of the exterior wall ( 4 ), the fluid uptake area ( 11 ) extending from the dispense aperture ( 8 ) towards the reception aperture ( 7 ) and being in fluid connection with the surrounding atmosphere at the reception aperture ( 7 ), the pipette tip extension being configured as an integrally produced workpiece, and being made of a non-polar olefine based polypropylene (PP) composition comprising at least 85% of a heterophasic polypropylene copolymer (h-PP), the latter comprising a propylene random copolymer matrix phase (r-PPM), an elastomeric propylene copolymer (e-PP) dispersed in the matrix, and optionally the PP composition may comprise polyethylene (PE) dispersed in the matrix, whereat the polypropylene composition has a shore hardness D from 45-60.

2 . The pipette tip extension according to claim 1 , whereat the polypropylene composition has:
a melting temperature between 130-160° C. and a melt flow rate (MFR, 230° C./2.16 kg) according to ISO 1133 from 0.5-6.0 g/10 min.

3 . The pipette tip extension according to claim 1 , whereat the heterophasic polypropylene copolymer (h-PP) comprises at least 65 to 90 wt-% of the propylene random copolymer matrix phase (r-PPM), whereat the comonomer of the r-PPM is ethylene and/or C 4 to C 12 olefins, and the h-PP comprises 15 to 35 wt-% of a dispersed phase comprising an elastomeric propylene copolymer (e-PP) having ethylene and/or C 4 to C 12 olefins as comonomers.

4 . The pipette tip extension according to claim 1 , whereat the r-PPM has ethylene as comonomer and/or the e-PP has ethylene as comonomer.

5 . The pipette tip extension according to claim 4 , whereat the ethylene comonomer content of the r-PPM is 3 to 20 wt-% with reference to the r-PPM.

6 . The pipette tip extension according to claim 4 , whereat the ethylene comonomer content of the e-PP is 20 to 40 wt-% with reference to the e-PP.

7 . The pipette tip extension according to claim 1 , whereat the content of the PE dispersed in the matrix phase is equal or less than 15 wt-% of the composition.

8 . The pipette tip extension according to claim 1 , the composition further comprising a polymeric α-nucleating agent in a range of 0.0001 to 5 wt-% of the composition.

9 . The pipette tip extension according to claim 1 , further comprising a constriction element ( 12 ) to control an insertion depth of a pipette tip ( 20 ) within the pipette tip extension ( 1 ), the constriction element defining a gap height between a distal end of an inserted pipette tip and the distal end of the pipette tip extension.

10 . The pipette tip extension according to claim 9 , the constriction element being configured as a fluid-permeable sieve-like structure, wherein the constriction element ( 12 ) comprises a guiding plate ( 14 ), support bars ( 15 ) and a connection channel ( 16 ), wherein the guiding plate ( 14 ) defines or is connected to an end stop ( 23 ) for a pipette tip ( 20 ), the guiding plate ( 14 ) being connected to an inner side ( 6 ) of the exterior wall ( 4 ) by the support bars 15 close to but offset of a distal end ( 3 ) of the pipette tip extension ( 1 ), delimiting together with the inner side ( 6 ) of the exterior wall ( 4 ) a gap ( 17 ) of a gap height (h) at the distal end ( 3 ) of the pipette tip extension ( 1 ), the support bars ( 15 ) providing one or more passages for fluidly connecting the gap ( 17 ) with the fluid uptake area ( 11 ).

11 . The pipette tip extension according to claim 1 , wherein the distance element(s)( 10 ) or the constriction element is or forms a sleeve ( 21 ) which is configured to receive and circumferentially enclose a distal end of a pipette tip ( 20 ) within the inner cavity ( 9 ), wherein the sleeve ( 21 ) is adapted to the shape of a distal end of a pipette tip ( 20 ) in a liquid-tight manner.

12 . The pipette tip extension ( 1 ) according to claim 1 , comprising at least two, preferably at least three additional distance elements ( 10 ), each distance element ( 10 ) being configured as a distance bar ( 24 ) which extends along a direction from the proximal end ( 2 ) towards the distal end ( 3 ) of the pipette tip extension ( 1 ), wherein the form of the distance bars and the position of the distance bars are configured such that each distance bar ( 24 ) can be abutted by an outer side of a pipette tip ( 20 ) when inserted into the pipette tip extension ( 1 ).

13 . The pipette tip extension according to claim 9 , wherein the distance element(s) ( 10 ) is connected to the inner side ( 6 ) of the exterior wall ( 4 ), and the constriction element ( 12 ) is connected to the inner side ( 6 ) of the exterior wall ( 4 ) of the pipette tip extension ( 1 ), thereby defining an end stop ( 23 ) for a pipette tip ( 20 ), and being configured as a fluid-permeable sieve-like structure.

14 . The pipette tip extension ( 1 ) according to claim 1 , wherein the distance element ( 10 ) is configured as a sleeve ( 21 ) for receiving and circumferentially enclosing a distal end of a pipette tip ( 2 ), the sleeve ( 21 ) being open at the distal end for allowing a liquid being dispensed from an inserted pipette tip ( 20 ) into the gap ( 17 ), and wherein the end stop ( 23 ) is configured as an elongated, tubular hollow cylinder which provides a passage for fluidly connecting an inserted pipette tip ( 20 ) with the gap ( 17 ),
wherein the sleeve ( 21 ) and the end stop ( 23 ) are fluidly connected to provide the fluid connection between the pipette tip ( 20 ) and the gap ( 17 ).

15 . The pipette tip extension ( 1 ) according to claim 1 , wherein the guiding plate ( 14 ) is configured as a ring-like guiding plate ( 14 ) or as a shim-like guiding plate ( 14 ) or as a plate-like guiding plate ( 14 ).

16 . The pipette tip extension according to claim 10 , wherein the one or more support bars ( 15 ) connecting the guiding plate to the inner side ( 6 ) of the exterior wall ( 4 ), or a connection element ( 28 ) connecting the inner wall to the sleeve have a cut out section ( 29 ) provided to extend the height (h) of the gap immediately adjacent to the inner side ( 6 ) of the exterior wall ( 4 ).

17 . The pipette tip extension according to claim 1 , wherein the pipette tip extension is produced by injection molding of the respective polypropylene composition.

18 . The pipette tip extension according to claim 1 , wherein the parting line ( 30 ) of at least two mold parts used to produce the pipette tip extension is shifted into the dispense aperture ( 8 ) or into the connection channel ( 16 ).

Assignees

• Tecan Trading Ag

Inventors

• Sager Adrian

Classifications

• B01L3/0275 Primary

  Interchangeable or disposable dispensing tips · CPC title

• B01L2300/123

  Flexible; Elastomeric · CPC title

• B01L2200/026

  Fluid interfacing between devices or objects, e.g. connectors, inlet details · CPC title

• B01L2200/04

  Exchange or ejection of cartridges, containers or reservoirs · CPC title

• B01L2300/06

  Auxiliary integrated devices, integrated components · CPC title