Saponin containing extracts prepared from hesperaloe useful in the treatment of non-human animals

Patent metadata

Field	Value
Publication number	US-2023263815-A1
Application number	US-202118011341-A
Country	US
Kind code	A1
Filing date	Jun 21, 2021
Priority date	Jun 19, 2020
Publication date	Aug 24, 2023
Grant date	—

Abstract

Disclosed are animal feed compositions comprising a saponin extracted from a non-woody plant of the genus Hesperaloe. The saponin containing extracts, which generally constitute the water soluble fraction, are useful as additives to basal animal feed to reduce the production of ammonia. In certain embodiments, saponin containing compositions of the present invention may inhibit proteolytic microorganisms, reducing ammonia and improving animal welfare and animal performance. In other embodiments, administration of saponin containing compositions of the present invention to non-human animal inhibits the release of gaseous ammonia through the inhibition urease. The compositions of the present invention may be administered to non-human animals, particularly poultry, to reduce ammonia emissions. In certain embodiment, the animal feed composition comprises a basal animal feed and an extract from a non-woody plant of the genus Hesperaloe, the extract comprising 25(27)-dehydrofucreastatin, 5(6), 25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin, yuccaloiside, or a mixture thereof.

First claim

What is claimed is:

1 . An animal feed composition for reducing gaseous emissions, the feed comprising:
a. a basal animal feed; and b. an extract from a non-woody plant of the genus Hesperaloe , the extract comprising 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin, yuccaloiside, or a mixture thereof.

2 . The animal feed composition of claim 1 comprising from about 1 to about 100 g of total saponins per 100 kg of basal animal feed.

3 . The animal feed composition of claim 1 wherein extract solids further comprise saccharides, proteins, lipids, or a mixture thereof.

4 . The animal feed composition of claim 1 wherein the extract substantially free from saccharides, proteins, and lipids.

5 . The animal feed composition of claim 1 wherein the extract comprises at least about 90% water soluble solids.

6 . The animal feed composition of claim 1 wherein the extract comprises less than about 2% water insoluble solids.

7 . The animal feed composition of claim 1 wherein the extract comprises 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside, 5(6)-disdehydroyuccaloiside, furcreastatin and yuccaloiside.

8 . The animal feed composition of claim 1 wherein the non-woody plant is selected from Hesperaloe funifera, Hesperaloe nocturne, Hesperaloe parviflora and Hesperaloe chiangii,

9 . The animal feed composition of claim 1 comprising from about 100 to about 1,000 g water soluble solids per kilogram of basal animal feed.

10 . The animal feed composition of claim 1 wherein the extract comprise from about 5 to about 25 wt % saponin.

11 . The animal feed composition of claim 10 wherein the saponins comprise a mixture of 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside, furcreastatin and yuccaloiside C.

12 . A method of reducing gaseous emissions from a non-human animal comprising administering thereto a feed composition comprising a basal animal feed and an extract from a non-woody plant of the genus Hesperaloe , the extract comprising at least one saponin.

13 . The method of claim 12 wherein the total amount of saponin ranges from about 1 to about 100 g per 100 kg of animal feed.

14 . The method of claim 12 wherein the extract further comprise saccharides, proteins, and lipids.

15 . The method of claim 12 wherein the extract is substantially free from saccharides, proteins, and lipids.

16 . The method of claim 12 wherein the at least one saponin is selected from 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside, furcreastatin and yuccaloiside C.

17 . The method of claim 12 wherein the extract comprise a mixture of 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside, furcreastatin and yuccaloiside C.

18 . The method of claim 12 wherein the feed composition comprises from about 100 to about 1,000 g water soluble solids per kilogram of basal animal feed.

19 . The method of claim 12 wherein the extract comprises from about 10 to about 25 wt % saponin.

20 . The method of claim 12 wherein the gas emissions are ammonia or carbon dioxide.

21 . The method of claim 12 wherein the non-human is a bovine, a fowl, a porcine, an ovine or an equine species.

22 . The method of claim 12 wherein the feed composition is administered orally.

23 . The method of claim 12 wherein the feed composition is a liquid, a slurry, a dry powder, a dry granular mix, a paste, or a solid.

24 . The method of claim 12 wherein the basal animal feed comprises one or more of corn meal, corncob grits, soybean meal, alfalfa meal, rice hulls, soybean mill run, cottonseed oil meal, bone meal, ground corn, corncob meal, wheat middlings, limestone, dicalcium phosphate, sodium chloride, urea or distillers dried grain.

25 . The method of claim 12 wherein the basal animal feed comprises water and is a liquid.

Assignees

• Kimberly Clark Co

Inventors

• Wei Ning
• Shannon Thomas G

Classifications

• A61P33/02

  Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis · CPC title

• A61K39/012

  Coccidia antigens · CPC title

• A61K39/39

  characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title

• A61K2039/55577

  Saponins; Quil A; QS21; ISCOMS · CPC title

• A61K31/704

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title