Bioprocessing system and tubing and component management apparatus for a bioprocessing system

Patent metadata

Field	Value
Publication number	US-2023250380-A1
Application number	US-202118014370-A
Country	US
Kind code	A1
Filing date	Jul 8, 2021
Priority date	Jul 15, 2020
Publication date	Aug 10, 2023
Grant date	—

Abstract

A component management apparatus for a bioprocessing system includes a frame having a plurality of segments, including at least a first segment and a second segment pivotably connected to the first segment such that at least the second segment is movable between a closed position and an open position, and at least one mounting bracket connected to the frame for connection of a bioprocess component.

First claim

1 . A component management apparatus for a bioprocessing system, comprising:
a frame having a plurality of segments, including at least a first segment and a second segment pivotably connected to the first segment such that at least the second segment is movable between a closed position and an open position; and at least one mounting bracket connected to the frame for connection of a bioprocess component.

2 . The component management apparatus of claim 1 , further comprising:
a connection mechanism configured to maintain the second segment in the closed position.

3 . The component management apparatus of claim 2 , wherein:
the connection mechanism is a mechanical lock or magnetic coupling.

4 . The component management apparatus of claim 1 , wherein:
the at least one mounting bracket is a filter heater mounting bracket configured for mounting a filter heater in a position generally above the frame.

5 . The component management apparatus of claim 1 , wherein:
the at least one mounting bracket is a pinch valve mounting bracket configured for receiving a pinch valve, the pinch valve mounting bracket depending downwardly from the frame.

6 . The component management apparatus of claim 1 , wherein:
the at least one mounting bracket is a plurality of mounting brackets; wherein the plurality of mounting brackets include a plurality of filter heater mounting brackets configured for mounting filter heaters in a position generally above the frame; and wherein the plurality of mounting brackets further include a plurality of pinch valve mounting brackets configured for receiving pinch valves, the plurality of pinch valve mounting brackets depending downwardly from the frame.

7 . The component management apparatus of claim 1 , wherein:
the plurality of segments further include at least a third segment; wherein the first segment is arcuate in shape and has a first end and a second end; wherein the second segment is pivotably connected to the first end of the first segment; and wherein the third segment is pivotably connected to the second end of the first segment.

8 . The component management apparatus of claim 7 , wherein:
at least one of the first segment, the second segment and/or the third segment is shaped and/or dimensioned to correspond to an internal wall of a bioreactor vessel; and at least another of the first segment, the second segment and / or the third segment is shaped and dimensioned so as to accommodate an internal baffle of the bioreactor vessel.

9 . The component management apparatus of claim 1 , wherein:
the frame has a peripheral shape that corresponds to an interior sidewall of the bioreactor vessel and internal baffles of the bioreactor vessel.

10 . The component management apparatus of claim 1 , wherein:
at least one of the segments is movable so as to extend from an opening in a bioreactor vessel to which the frame is connected.

11 . The component management apparatus of claim 4 , further comprising:
a filter heater holder mounted to the filter heater mounting bracket, the filter heater holder including a plurality of interconnected sleeve elements forming a sleeve having a top opening, the sleeve having a cross-sectional area that is greatest at the top opening and decreases moving away from the top opening; wherein the sleeve elements are configured so as to be biased outwardly upon insertion of a filter heater or filter through the top opening.

12 . A bioprocessing system, comprising:
a vessel defining an interior space for receiving a flexible bioprocessing bag, the vessel having an access door in a sidewall of the vessel providing access to the interior space; and a tubing and component management apparatus operatively connected to the vessel for mounting at least one component of the bioprocessing system; wherein the tubing and component management apparatus includes a frame having a plurality of segments including at least a first segment and a second segment pivotably connected to the first segment such that at least the second segment is movable between a closed position and an open position, and at least one mounting bracket connected to the frame for connection of the at least one component.

13 . The bioprocessing system of claim 12 , wherein:
the frame is moveable vertically into and out of the interior space.

14 . The bioprocessing system of claim 12 , wherein:
the frame is fixed to the vessel.

15 . The bioprocessing system of any one of claim 12 , wherein:
the tubing and component management apparatus further includes a connection mechanism configured to maintain the second segment in the closed position; wherein the connection mechanism is a mechanical lock or magnetic coupling.

16 . The bioprocessing system of any one of claim 12 , wherein:
the at least one mounting bracket is a plurality of mounting brackets; wherein the plurality of mounting brackets include a plurality of filter heater mounting brackets configured for mounting filter heaters in a position generally above the frame; and wherein the plurality of mounting brackets further include a plurality of pinch valve mounting brackets configured for receiving pinch valves, the plurality of pinch valve mounting brackets depending downwardly from the frame.

17 . The bioprocessing system of any one of claim 12 , wherein:
the frame has a peripheral shape that corresponds to an interior sidewall of the bioreactor vessel and internal baffles of the bioreactor vessel.

18 . The bioprocessing system of any one of claim 12 , wherein:
at least one of the segments is movable so as to extend from an access door opening in the bioreactor vessel.

19 . The bioprocessing system of any one of claim 12 , further comprising a filter heater, the filter heater comprising:
a sleeve having a plurality of interconnected sleeve elements, the sleeve having a top opening; wherein the sleeve has a cross-sectional area that is greatest at the top opening and decreases moving away from the top opening; and wherein the sleeve elements are configured so as to be biased outwardly upon insertion of a filter heater through the top opening.

20 . The bioprocessing system of claim 19 , wherein:
the plurality of sleeve elements are interconnected by webs of material adjacent to the top opening; and wherein distal portions of the plurality of sleeve elements opposite the top opening are configured to be resiliently biased by the filter heater.

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Stegner Elizabeth
• Murugesan Kandakumar
• Cherunni Sairam
• Dash Manas
• Bagiyanathan Prasad
• Selvaraj Shivakumar
• Kandoth Bineesh
• Maiya Nityananda
• Brocato Nicholas
• Dhanariya Chandra Prakash
• Sundaramoorthy Suresh

Classifications

• C12M23/46 Primary

  Means for fastening · CPC title

• C12M23/14

  Bags · CPC title

• C12M23/48

  Holding appliances; Racks; Supports (holding devices for laboratory apparatus B01L9/00) · CPC title

• C12M25/10

  Hollow fibers or tubes (hollow fiber modules in general B01D63/02) · CPC title

• C12M27/20

  Baffles; Ribs; Ribbons; Auger vanes · CPC title