High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods

Patent metadata

Field	Value
Publication number	US-2023248973-A1
Application number	US-202318131760-A
Country	US
Kind code	A1
Filing date	Apr 6, 2023
Priority date	Jan 19, 2017
Publication date	Aug 10, 2023
Grant date	—

Abstract

High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods. A representative method includes addressing the patient's somatosensory dysfunction and/or motor dysfunction, resulting from neuropathy and/or spinal cord injury, by directing an electrical therapy signal to the patient's spinal cord region, the therapy signal having a frequency in a frequency range from 1.5 kHz to 100 kHz.

First claim

1 - 30 . (canceled)

31 . A method of treating a patient having diabetic neuropathy, via spinal cord stimulation, comprising:
at least partially in response to the patient having a symptom of tingling caused by the patient's diabetic neuropathy, programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia producing electrical signal has a frequency of 10 kHz, a pulse width in a pulse width range of from about 30 microseconds to about 35 microseconds, and an amplitude in an amplitude range of from 0.5 mA to 7 mA, wherein the non-paresthesia producing electrical signal at least partially eliminates the tingling caused by the diabetic neuropathy without causing a side-effect of signal-induced paresthesia.

32 . The method of claim 31 wherein the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region.

33 . The method of claim 31 wherein the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region between T8 and T12, inclusive.

34 . The method of claim 31 wherein the at least one implanted signal delivery element is positioned in the patient's epidural space.

35 . The method of claim 31 wherein the tingling is in the patient's foot.

36 . The method of claim 31 wherein the patient also has foot pain caused by the patient's diabetic neuropathy, and wherein the non-paresthesia producing electrical signal also reduces the patient's foot pain without causing the side-effect of signal-induced paresthesia.

37 . The method of claim 36 wherein programming the signal generator is performed at least partially in response to the patient having foot pain.

38 . A method of treating a patient having diabetic neuropathy, via spinal cord stimulation, comprising:
at least partially in response to the patient having a symptom of tingling associated with the patient's diabetic neuropathy, programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia-producing electrical signal has a frequency in a frequency range of from about 5 kHz to about 15 kHz, a pulse width in a pulse width range of from about 20 microseconds to about 40 microseconds, and an amplitude in an amplitude range of from 0.5 mA to 10 mA, wherein the non-paresthesia producing electrical signal at least partially eliminates the tingling associated with the diabetic neuropathy without causing a side-effect of signal-induced paresthesia.

39 . The method of claim 38 wherein the at least one implanted signal delivery element is positioned in the patient's epidural space at a thoracic vertebral region between T8 and T12, inclusive.

40 . The method of claim 38 wherein the non-paresthesia producing electrical signal has a duty cycle of between about 10% and about 100%.

41 . The method of claim 40 wherein the non-paresthesia producing electrical signal has a duty cycle of about 14%.

42 . The method of claim 38 wherein the tingling is concentrated in one or both of the patient's feet and/or one or both of the patient's hands.

43 . The method of claim 38 wherein the signal generator is implanted.

44 . A method of treating a patient having diabetic neuropathy, via spinal cord stimulation, comprising:
at least partially in response to the patient having tingling associated with the patient's diabetic neuropathy, programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia producing electrical signal has a frequency in a frequency range of from about 1.5 kHz to about 20 kHz, a pulse width in a pulse width range of from about 20 microseconds to about 100 microseconds, and an amplitude in an amplitude range of from 0.5 mA to 10 mA, wherein the non-paresthesia producing electrical signal at least partially eliminates the tingling associated with the diabetic neuropathy without causing a side-effect of signal-induced paresthesia.

45 . The method of claim 44 wherein the at least one implanted signal delivery element is positioned at a thoracic vertebral region between T8 and T12, inclusive.

46 . The method of claim 44 wherein the non-paresthesia producing electrical signal has a duty cycle of between about 10% and about 100%.

47 . The method of claim 46 wherein the non-paresthesia producing electrical signal has a duty cycle of about 14%.

48 . The method of claim 44 wherein the tingling is in one or both of the patient's feet.

49 . The method of claim 44 wherein the signal generator is implanted.

50 . The method of claim 44 wherein the signal generator is external.

Assignees

• Nevro Corp

Inventors

• Subbaroyan Jeyakumar
• Bradley Kerry
• Lee Dongchul

Classifications

• A61N1/36062 Primary

  Spinal stimulation · CPC title

• A61N1/36171

  Frequency · CPC title

• A61N1/37217

  characterised by the communication link, e.g. acoustic or tactile · CPC title

• A61N1/36157

  Current (A61N1/3616 takes precedence) · CPC title

• A61N1/36175

  Pulse width or duty cycle · CPC title