High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods

Patent metadata

Field	Value
Publication number	US-2023241388-A1
Application number	US-202318131791-A
Country	US
Kind code	A1
Filing date	Apr 6, 2023
Priority date	Jan 19, 2017
Publication date	Aug 3, 2023
Grant date	—

Abstract

High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods. A representative method includes addressing the patient's somatosensory dysfunction and/or motor dysfunction, resulting from neuropathy and/or spinal cord injury, by directing an electrical therapy signal to the patient's spinal cord region, the therapy signal having a frequency in a frequency range from 1.5 kHz to 100 kHz.

First claim

1 - 30 . (canceled)

31 . A method of treating a patient having diabetic neuropathy, via spinal cord stimulation, comprising:
at least partially in response to the patient having symptoms of tingling and sensation loss caused by the patient's diabetic neuropathy, programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia producing electrical signal has a frequency of 10 kHz, a pulse width in a pulse width range of from about 30 microseconds to about 35 microseconds, and an amplitude in an amplitude range of from 0.5 mA to 7 mA, wherein the non-paresthesia producing electrical signal (a) at least partially eliminates the tingling, and (b) at least partially restores sensation.

32 . The method of claim 31 wherein the tingling and the sensation loss are in the patient's foot.

33 . The method of claim 31 wherein the patient also has pain caused by the patient's diabetic neuropathy, and wherein the non-paresthesia producing electrical signal (c) at least partially reduces the pain.

34 . The method of claim 33 wherein the pain is in the patient's foot.

35 . The method of claim 33 wherein programming the signal generator is performed at least partially in response to the patient having the pain.

36 . The method of claim 31 wherein the patient does not have pain caused by the patient's diabetic neuropathy.

37 . The method of claim 31 wherein the at least one implanted signal delivery element is positioned in the patient's epidural space at a thoracic vertebral region between T8 and T12, inclusive.

38 . A method of treating a patient having diabetic neuropathy, via spinal cord stimulation, comprising:
at least partially in response to the patient having tingling and sensation loss associated with the diabetic neuropathy, programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia-producing electrical signal has a frequency in a frequency range of from about 5 kHz to about 15 kHz, a pulse width in a pulse width range of from about 20 microseconds to about 40 microseconds, and an amplitude in an amplitude range of from 0.5 mA to 10 mA, wherein the non-paresthesia producing electrical signal (a) at least partially eliminates the tingling, and (b) at least partially restores sensation.

39 . The method of claim 38 wherein the tingling and sensation loss are in the patient's foot and/or leg.

40 . The method of claim 39 wherein the patient also has foot and/or leg pain associated with the patient's diabetic neuropathy, and wherein the non-paresthesia producing electrical signal (c) at least partially reduces the foot and/or leg pain.

41 . The method of claim 38 wherein the patient does not have foot and/or leg pain associated with the patient's diabetic neuropathy.

42 . The method of claim 38 wherein the at least one implanted signal delivery element is positioned in the patient's epidural space at a thoracic vertebral region between T8 and T12, inclusive.

43 . The method of claim 38 wherein the signal generator is implanted.

44 . A method of treating a patient having diabetic neuropathy, via spinal cord stimulation, comprising:
at least partially in response to the patient having tingling and sensation loss associated with the diabetic neuropathy, programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia-producing electrical signal has a frequency in a frequency range of from about 1.5 kHz to about 20 kHz, a pulse width in a pulse width range of from about 20 microseconds to about 100 microseconds, and an amplitude in an amplitude range of from 0.5 mA to 10 mA, wherein the non-paresthesia producing electrical signal (a) at least partially eliminates the tingling, and (b) at least partially restores sensation.

45 . The method of claim 44 wherein the patient also has foot and/or leg pain associated with the patient's diabetic neuropathy, and wherein the non-paresthesia producing electrical signal (c) at least partially reduces the foot and/or leg pain.

46 . The method of claim 44 wherein the patient does not have foot and/or leg pain associated with the patient's diabetic neuropathy.

47 . The method of claim 44 wherein the tingling and sensation loss are concentrated in the patient's feet and/or hands.

48 . The method of claim 44 wherein the at least one implanted signal delivery element is positioned at a thoracic vertebral region between T8 and T12, inclusive.

49 . The method of claim 44 wherein the signal generator is implanted.

50 . The method of claim 44 wherein the signal generator is external.

Assignees

• Nevro Corp

Inventors

• Subbaroyan Jeyakumar
• Bradley Kerry
• Lee Dongchul

Classifications

• A61N1/36062 Primary

  Spinal stimulation · CPC title

• A61N1/36171

  Frequency · CPC title

• A61N1/37217

  characterised by the communication link, e.g. acoustic or tactile · CPC title

• A61N1/36157

  Current (A61N1/3616 takes precedence) · CPC title

• A61N1/36175

  Pulse width or duty cycle · CPC title