Needle free delivery system and operation method thereof

Patent metadata

Field	Value
Publication number	US-2023233181-A1
Application number	US-202217661564-A
Country	US
Kind code	A1
Filing date	May 1, 2022
Priority date	Jan 27, 2022
Publication date	Jul 27, 2023
Grant date	—

Abstract

The present disclosure provides a needle free delivery system, which includes a handheld device and a signal switching device. The signal switching device is electrically connected to the handheld device, and the handheld device includes an ultrasonic probe. The signal switching device provides a burst wave capable of generating a resonant carrier wave through piezoelectric material to the handheld device, so that an ultrasonic wave of the handheld device can perform a needleless delivery on a carrier.

First claim

What is claimed is:

1 . A needle free delivery system, comprising:
a handheld device comprising an ultrasonic probe; and a signal switching device electrically connected to the handheld device, and the signal switching device configured to provide a burst wave capable of generating a resonant carrier wave through a piezoelectric material to the handheld device, so that a ultrasonic wave performs a needleless delivery on a carrier.

2 . The needle free delivery system of claim 1 , wherein the signal switching device comprises:
a timer configured to generate a clock signal; and a conversion module electrically connected to the timer, and the conversion module based on the clock signal to convert an input voltage into the burst wave capable of generating the resonant carrier wave through the piezoelectric material.

3 . The needle free delivery system of claim 1 , wherein the handheld device comprises:
a probe circuit electrically connected to the ultrasonic probe.

4 . The needle free delivery system of claim 3 , wherein the probe circuit comprises:
an ultrasonic driver module configured to receive the burst wave capable of generating the resonant carrier wave through the piezoelectric material and to generate a burst wave signal capable of generating a plurality of resonant carrier waves with a plurality of ultrasonic frequencies through a plurality of piezoelectric materials; and a plurality of matching circuits electrically connected to the ultrasonic driver module and a plurality of transducer probes, the matching circuits configured to match impedances of the ultrasonic drive module and the transducer probes respectively, wherein the transducer probes are integrated into the ultrasonic probe.

5 . The needle free delivery system of claim 1 , wherein the handheld device further comprises:
a holder surrounding the ultrasonic probe; and a detachable dialysis membrane detachably sleeved on the holder, the detachable dialysis membrane having a perfusion area, and the perfusion area configured to accommodate the carrier and to access the ultrasonic probe.

6 . The needle free delivery system of claim 5 , wherein the handheld device further comprises:
a probe extension part connected to the ultrasonic probe and extending out of the holder, an end of the probe extension part being an output end, and the output end configured to send out the carrier.

7 . The needle free delivery system of claim 1 , wherein the handheld device further comprises:
a grip part; and a fixing part connected with the grip part, the ultrasonic probe exposed on one side of the fixing part, and the ultrasonic probe being a plane ultrasonic probe without a waveguide.

8 . The needle free delivery system of claim 1 , wherein the ultrasonic probe is an ultrasonic probe with a needle-type waveguide.

9 . The needle free delivery system of claim 8 , wherein the ultrasonic probe with the needle-type waveguide is an ultrasonic probe with a flexible needle-type waveguide.

10 . The needle free delivery system of claim 8 , wherein the ultrasonic probe with the needle-type waveguide has a first end and a second end opposite to each other, and a diameter of the first end is smaller than a diameter of the second end, wherein the handheld device further comprises:
a sleeve-type perfusion container detachably sleeved on the first end of the ultrasonic probe with the needle-type waveguide; and a stopper connected to the second end of the ultrasonic probe with the needle-type waveguide.

11 . The needle free delivery system of claim 1 , wherein the ultrasonic probe is a planar ultrasonic probe without a waveguide, and the handheld device further comprises:
a perfusion container having one side connected to the planar ultrasonic probe without the waveguide; a detachable rubber membrane detachably disposed on another side of the perfusion container; and a leak-proof rubber frame disposed on the perfusion container and surrounding the detachable rubber membrane.

12 . The needle free delivery system of claim 1 , wherein the handheld device further comprises:
an atomizer configured to atomize the carrier.

13 . The needle free delivery system of claim 12 , wherein the atomizer emits the ultrasonic wave.

14 . The needle free delivery system of claim 1 , wherein the ultrasonic probe comprises:
a hose; a spray tube surrounded by the hose; and an ultrasonic transducer having a hollow tubular shape, wherein an outer diameter of the ultrasonic transducer is smaller than an inner diameter of the hose, an inner diameter of the ultrasonic transducer is larger than an outer diameter of the spray tube, an ultrasonic resonant surface of the ultrasonic transducer and an outlet of the spray tube both point outward in a same direction, and the ultrasonic transducer emits the ultrasonic waves to the spray tube, so that the spray tube delivers the carrier.

15 . The needle free delivery system of claim 1 , wherein the ultrasonic probe comprises:
a hose; a spray tube surrounded by the hose; and an endoscope detachably disposed on the spray tube.

16 . An operation method of a needle free delivery system, the needle free delivery system comprising a handheld device and a signal switching device, and the operation method comprising:
using the signal switching device to provide a burst wave capable of generating a resonant carrier wave through a piezoelectric material to the handheld device, so that an ultrasonic wave of the handheld device performs a needleless delivery on a carrier.

17 . The operation method of claim 16 , further comprising:
using the signal switching device to generate a clock signal, so as to convert an input voltage into the burst wave capable of generating the resonant carrier wave through the piezoelectric material according to the clock signal.

18 . The operation method of claim 17 , further comprising:
using the handheld device to receive the burst wave capable of generating the resonant carrier wave through the piezoelectric material and to generate a burst wave signal capable of generating a plurality of resonant carrier waves with a plurality of ultrasonic frequencies through a plurality of piezoelectric materials.

19 . The operation method of claim 16 , further comprising:
using an atomizer to atomize the carrier.

20 . The operation method of claim 19 , further comprising:
using the atomizer to emit the ultrasonic wave.

Assignees

• Univ Nat Taiwan Science & Technology
• Univ Nat Taiwan
• Nat Defense Medical Center

Inventors

• Liao Ai-Ho
• Wang Chih-Hung
• Liu Hao-Li

Classifications

• A61B8/481 Primary

  involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream · CPC title

• A61B8/4444 Primary

  related to the probe · CPC title

• A61B8/4488

  the transducer being a phased array · CPC title

• A61B8/4494

  characterised by the arrangement of the transducer elements · CPC title

• A61B8/12

  in body cavities or body tracts, e.g. by using catheters · CPC title