Filtration devices and methods related thereto

Patent metadata

Field	Value
Publication number	US-2023225850-A1
Application number	US-202218084230-A
Country	US
Kind code	A1
Filing date	Dec 19, 2022
Priority date	Aug 12, 2015
Publication date	Jul 20, 2023
Grant date	—

Abstract

In vivo and ex vivo positionable filtration devices are provided that are functionalized to bind one or more therapeutic agents in blood flowing in a blood vessel.

First claim

1 . A filtration device for filtering one or more therapeutic agents in blood flowing in a blood vessel, the filtration device comprising:
a solid elongated member; at least one channel or a plurality of channels formed in the solid elongated member, wherein the channel(s) extends along a longitudinal axis of the solid elongated member; wherein the filtration device is dimensioned for positioning within a blood vessel of a human or non-human animal; and wherein the filtration device comprises a surface functionalized to bind to a therapeutic agent in blood flowing through the filtration device.

2 . The filtration device according to claim 1 , wherein the solid elongated member comprises a cylindrical member comprising a frustoconical leading edge opposite a planar edge;
a plurality of channels formed in the solid elongated member, wherein the channels extend from the frustoconical leading edge to the planar edge.

3 . The filtration device according to claim 1 , wherein the solid elongated member is a cylindrical member comprising a first planar edge opposite a second planar edge and a plurality of channels extending from the first planar edge to the second planar edge.

4 . The filtration device according to claim 1 , wherein a channel of the plurality of channels is located in the center of the device and remaining plurality of channels are arranged concentrically around the central channel.

5 . The filtration device according to claim 1 , wherein the plurality of channels are (i) parallel to each other, (ii) extend along a non-linear path between the ends of the device, (iii) extend along a linear path between the ends of the device and are not parallel to each other.

6 . The filtration device according to claim 2 , wherein the plurality of channels are parallel to a longitudinal axis of the device, the longitudinal axis extending from the frustoconical leading edge to the planar edge.

7 . The filtration device according to claim 1 , wherein the cylindrical member is dimensioned to (a) fill a cross-section of the blood vessel, (b) have a diameter smaller than the blood vessel diameter, or (c) have a diameter larger than the blood vessel diameter.

8 . The filtration device according to claim 1 , wherein a surface of the device at one or more edge and/or a surface of the plurality of channels of the device is functionalized to bind to a first therapeutic agent or to a plurality of therapeutic agents.

9 . The filtration device according to claim 1 , wherein the plurality of channels comprise a circular or an oval shaped opening at an edge of the device.

10 . The filtration device according to claim 1 , wherein the plurality of channels comprise a hexagonal opening at an edge of the device.

11 . The filtration device according to claim 1 , wherein the periphery of the plurality of channels comprise a hexagonal shape along the length of the channels.

12 . The filtration device according to claim 1 , wherein the periphery of the plurality of channels comprise a cylindrical shape along the length of the channels.

13 . The filtration device according to claim 1 , wherein the outer surface of the device and/or the interior surface of the channels is functionalized with a moiety for binding to a first therapeutic agent.

14 . The filtration device according to claim 1 , wherein the outer surface of the device and/or the interior surface of the channels is functionalized with a plurality of moieties for binding to a plurality of therapeutic agents.

15 . A method for filtering a therapeutic agent from blood, the method comprising:
positioning a filtration device of claim 1 in a blood vessel of a body of a human or non-human animal, the filtration device positioned downstream from a target tissue site; and administering a therapeutic agent upstream from the target tissue site to direct flow of the therapeutic agent to the target tissue site and then to the filtration device; wherein the in vivo positioned filtration device binds the therapeutic agent as the blood containing the therapeutic agent traverses through the filtration device.

16 . The method according to claim 15 , further comprising:
removing the filtration device from the blood vessel of the body of the human or non-human animal after a completion of the filtering of the therapeutic agent.

17 . The method according to claim 15 , wherein the positioning of the filtration device comprises:
inserting a catheter within the blood vessel downstream from the target tissue site, wherein the catheter comprises the filtration device in a distal end of the catheter; and displacing the filtration device at least partially out the distal end of the catheter to position the filtration device downstream from the target tissue site in the blood vessel.

18 . The method according to claim 15 , wherein the filtration device is positioned 10 mm to 1000 mm downstream from the target tissue site.

19 . The method according to claim 15 , wherein the catheter is positioned concentrically around the filtration device when the catheter is inserted within the blood vessel.

20 . The method according to claim 16 , further comprising:
inserting a replacement filtration device within the catheter; displacing the replacement filtration device at least partially out the distal end of the catheter to position the replacement filtration device downstream from the target tissue site in the blood vessel.

Assignees

• Univ California

Inventors

• Kilbride Bridget F
• Thorne Bradford R H
• Hetts Steven W
• Rayz Vitaliy Lvovich

Classifications

• A61F2/01 Primary

  Filters implantable into blood vessels · CPC title

• A61M1/3615

  Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit · CPC title

• A61M1/3687

  Chemical treatment (A61M1/3675 takes precedence) · CPC title

• A61B2017/00871

  polymeric · CPC title

• A61B2017/00893

  pharmaceutically effective · CPC title