Biodegradable iron-containing compositions, methods of preparing and applications therefor

Patent metadata

Field	Value
Publication number	US-2023211053-A1
Application number	US-202318113676-A
Country	US
Kind code	A1
Filing date	Feb 24, 2023
Priority date	Oct 5, 2012
Publication date	Jul 6, 2023
Grant date	—

Abstract

The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular.

First claim

1 . A biodegradable iron-based alloy, comprising:
magnesium, manganese and calcium; and a remainder of iron.

2 . The alloy of claim 1 , wherein the magnesium constitutes from greater than zero weight percent to about 10.0 weight percent, the manganese constitutes from about 5.0 weight percent to about 75.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 10.0 weight percent, based on total weight of the composition.

3 . A method of preparing a biodegradable iron-based alloy, comprising:
charging in a high energy mill (i) magnesium, manganese, calcium, and a remainder of iron, or (ii) magnesium, zirconium, calcium, and a remainder of iron, or (iii) magnesium, zinc, calcium, and a remainder of iron; and conducting high energy milling of the magnesium, manganese, calcium and a remainder of iron.

4 . The method of claim 3 , wherein the high energy milling is conducted in dry conditions followed by high energy milling conducted in wet conditions.

5 . The method of claim 3 , wherein material resulting from the high energy milling is subjected to a casting process to form an iron-based alloy cast.

6 . The method of claim 3 , wherein for (i) the magnesium constitutes from greater than zero weight percent to about 10.0 weight percent, the manganese constitutes from about 5.0 weight percent to about 75.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 10.0 weight percent, based on total weight of the composition.

7 . The method of claim 3 , wherein for (ii) the magnesium constitutes from about greater than zero weight percent to about 7.0 weight percent, the zirconium constitutes from about 8.0 weight percent to about 52.0 weight percent, and the calcium constitutes from about greater than zero weight percent to about 30.0 weight percent, based on total weight of the composition.

8 . The method of claim 3 , wherein for (iii) the magnesium constitutes from about greater than zero weight percent to about 10.0 weight percent, the zinc constitutes from about greater than zero weight percent to about 10.0 weight percent, and the calcium constitutes from about greater than zero weight percent to about 30.0 weight percent, based on total weight of the composition.

9 . A biodegradable medical device comprising the iron-based alloy of claim 1 .

10 . The device of claim 9 , wherein said device is selected from the group consisting of plate, mesh, staple, screw, pin, tack, rod, suture anchor, tubular mesh, coil, x-ray marker, catheter, pipe, shield, bolt, clip, plug, dental implant, graft device, endoprosthesis, bone-fracture healing device, bone replacement device, joint replacement device, tissue regeneration device, cardiovascular stent, nerve guide, surgical implant, surgical wire and combinations thereof.

11 . The device of claim 9 , wherein said device is an implantable device.

12 . The device of claim 11 , wherein the implantable device is selected from the group consisting of an orthopedic device, a craniofacial device and a cardiovascular device.

Assignees

• Univ Pittsburgh Commonwealth Sys Higher Education

Inventors

• Kumta Prashant N
• Chung Sung Jae
• Saha Partha
• Velikokhatnyi Oleg
• Datta Moni Kanchan
• Hong Dae Ho
• Chou Da-Tren

Classifications

• C22C38/04

  containing manganese · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61L31/022 Primary

  Metals or alloys · CPC title

• C22C38/002

  containing In, Mg, or other elements not provided for in one single group C22C38/001 - C22C38/60 · CPC title

• C22C38/00

  Ferrous alloys, e.g. steel alloys (cast-iron alloys C22C37/00) · CPC title