Dental bone plug

Patent metadata

Field	Value
Publication number	US-2023211047-A1
Application number	US-202218091130-A
Country	US
Kind code	A1
Filing date	Dec 29, 2022
Priority date	Dec 31, 2021
Publication date	Jul 6, 2023
Grant date	—

Abstract

A method and system for making a bone plug using cortical bone material. A patient jaw having insufficient bone at a surgical site may be scanned to provide a 3D image which may be used to design a virtual bone plug and to fabricate the bone plug for placement within the patient. The bone plug may be formed from cortical bone that can be reconstituted and demineralized or demineralized and milled to shape.

First claim

What is claimed is:

1 . A method of forming a bone plug comprising:
at least one of milling or reconstituting a bone plug to a desired shape to yield a reconstituted bone plug, the bone plug comprising bone; and demineralizing the reconstituted bone plug until a desired percentage of bone morphogenetic proteins (BMP) is exposed in the reconstituted bone plug.

2 . The method of claim 1 , wherein the bone is cortical bone and comprises at least one of artificial bone, allograft bone, or xenograft bone.

3 . The method of claim 1 , wherein the bone plug is a patient specific bone plug.

4 . The method of claim 1 , further comprising:
obtaining a virtual 3D image of a patient including a bone void at a surgical site; determining dimensions of the bone void of the patient from the virtual 3D image; developing a 3D virtual representation of a bone plug; and determining features of the virtual representation of the bone plug corresponding to the desired shape.

5 . The method of claim 4 , wherein the virtual 3D image of the surgical site is obtained from a CBCT, MRI and/or intraoral scan.

6 . The method of claim 1 , wherein the desired percentage of the BMP exposed is less than or equal to about 8%.

7 . The method of claim 1 , wherein the reconstituted bone plug is demineralized using at least one of an acid solution, a phosphate buffered solution, an ethanol solution.

8 . The method of claim 1 , wherein a first portion of the reconstituted bone plug is demineralized to expose a first desired percentage of BMP and a second portion of the reconstituted bone plug is demineralized to expose a second desired percentage of BMP.

9 . A method of forming a bone plug comprising:
milling the bone plug to a desired shape; and demineralizing a bone plug until a desired percentage of bone morphogenetic proteins (BMP) is exposed, the bone plug comprising cortical bone.

10 . The method of claim 9 , further comprising:
obtaining a virtual 3D image of a patient including a bone void at a surgical site; determining dimensions of the bone void of the patient from the virtual 3D image; developing a 3D virtual representation of a bone plug; and determining features of the virtual representation of the bone plug corresponding to the desired shape.

11 . The method of claim 10 , wherein the virtual 3D image of the surgical site is obtained from a CBCT, MM and/or intraoral scan.

12 . The method of claim 9 , wherein the desired percentage of the BMP exposed is less than or equal to about 8%.

13 . The method of claim 9 , wherein the bone plug is demineralized using at least one of an acid solution, a phosphate buffered solution, an ethanol solution.

14 . The method of claim 9 , wherein a first portion of the bone plug is demineralized to expose a first desired percentage of BMP and a second portion of the bone plug is demineralized to expose a second desired percentage of BMP.

15 . A bone plug comprising:
a body extending from a first end to a second end, the body shaped in a desired shape using at least one of reconstitution or milling, and the body having a desired percentage of BMP exposed by demineralization.

16 . The bone plug of claim 15 , wherein the body comprises cortical bone.

17 . The bone plug of claim 16 , wherein the cortical bone comprises at least one of allograft and xenograft.

18 . The bone plug of claim 15 , wherein the bone plug is a patient specific bone plug.

19 . The bone plug of claim 15 , wherein the desired percentage of the BMP exposed is less than or equal to about 8%.

20 . The bone plug of claim 15 , wherein a first portion of the body is demineralized to expose a first desired percentage of BMP and a second portion of the body is demineralized to expose a second desired percentage of BMP.

Assignees

• Zimmer Biomet Spine Inc

Inventors

• Kumar Kaushal
• Berger Stefan

Classifications

• A61L27/3691

  characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation · CPC title

• A61L27/365

  Bones · CPC title

• A61L27/227 Primary

  Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24 · CPC title

• A61L27/3608

  Bone, e.g. demineralised bone matrix [DBM], bone powder · CPC title

• A61L27/3687

  characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents · CPC title