4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Patent metadata

Field	Value
Publication number	US-2023210808-A1
Application number	US-202318120484-A
Country	US
Kind code	A1
Filing date	Mar 13, 2023
Priority date	Sep 19, 2003
Publication date	Jul 6, 2023
Grant date	—

Abstract

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

First claim

1 - 56 . (canceled)

57 . A compound of Formula (II):

wherein
X is a covalent bond;
Y is S or O;
- - - - - W - - - - - represents a group selected from —CH═, —CH 2 —, —CH 2 —CH 2 —, —CH 2 —CH═, and —CH═CH—;
Z is selected from O, CH, and CH 2 , provided when Y is O, Z is O;
R 1 and R 2 are independently selected from H, C 1-3 alkyl, C 1-3 alkoxy, halo, and NR a R b wherein R a and R b are independently H or C 1-3 alkyl;
R 3 is independently selected from H, F, Cl, methyl, and methoxy and
R 4 is selected from H, Cl, and methyl; provided that R 3 and R 4 are not both H;
n is 1 or 2;

or a pharmaceutically acceptable salt thereof.

58 . (canceled)

59 . (canceled)

60 . (canceled)

61 . The compound of claim 57 wherein Y is O.

62 . The compound of claim 57 wherein Y is S.

63 . The compound of claim 57 wherein Z is O.

64 . The compound of claim 57 wherein Z is CH or CH 2 .

65 . The compound of claim 57 wherein - - - - - W - - - - - represents —CH 2 — or —CH 2 —CH 2 —.

66 . The compound of claim 65 wherein - - - - - W - - - - - represents —CH 2 —.

67 . The compound of claim 57 wherein - - - - - W - - - - - represents —CH═, —CH 2 —CH═, or —CH═CH—.

68 . (canceled)

69 . The compound of claim 57 wherein R 1 and R 2 are independently selected from H, C 1-3 alkyl, C 1-3 alkoxy, F, Cl, and Br.

70 . The compound of claim 69 wherein R 1 and R 2 are independently selected from H, methyl, methoxy, F and Cl.

71 - 75 . (canceled)

76 . The compound of claim 57 wherein R 1 is selected from H, CF 3 , methyl, Cl, and methoxy, and R 2 is selected from H, Cl, and methyl.

77 - 93 . (canceled)

94 . A pharmaceutical composition comprising a compound of claim 57 .

95 . (canceled)

Assignees

• Janssen Pharmaceutica Nv

Inventors

• Kuo Gee-Hong
• Zhang Rui
• Wang Aihua
• Deangelis Alan R

Classifications

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61K31/277 Primary

  having a ring, e.g. verapamil · CPC title

• C07C323/62

  having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton · CPC title

• C07C59/70 Primary

  Ethers of hydroxy-acetic acid {, e.g. substitutes on the ring} · CPC title

• C07C59/68

  the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring · CPC title