Uncaging stent

Patent metadata

Field	Value
Publication number	US-2023201014-A1
Application number	US-202318178377-A
Country	US
Kind code	A1
Filing date	Mar 3, 2023
Priority date	May 25, 2017
Publication date	Jun 29, 2023
Grant date	—

Abstract

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

First claim

1 . An endoluminal prosthesis comprising:
a scaffold patterned from a tubular body comprising a non-degradable material formed into a plurality of circumferential rings, said scaffold being configured to expand from a crimped configuration to an expanded configuration; wherein at least some of the circumferential rings comprise structural elements comprising struts joined by crowns, said structural elements comprising abluminal surfaces, luminal surfaces and two side surfaces; wherein at least some circumferential rings are axially joined to adjacent circumferential rings;
wherein at least some of the circumferential rings comprise at least one separation region comprising a pre-formed break in at least some circumferential rings, the preformed break providing a first segment having a first non-degradable free end on one side of the break in the circumferential ring from and a second segment having a second non-degradable free end on the other side of the break in the same circumferential ring, wherein prior to expansion said second free end fits into said first free end when the scaffold is in a crimped configuration; said first and second segments lying adjacent to each other along the side surfaces of said segments when the scaffold is in its crimped configuration; and
wherein said separation region is held together during expansion in a physiologic environment and is configured to separate at the break to form at least one discontinuity in said circumferential rings after expansion of the scaffold in said physiologic environment and wherein said at least one discontinuity allows a movement of said free ends relative to each other in an axial direction, a radial direction, a circumferential direction, or combinations thereof.

2 . An endoluminal prosthesis as in claim 1 , wherein the at least one separation region is joined by, covered by, or embedded in a biodegradable material comprising a polymer and/or adhesive formed as a coating, a sleeve, a solder, said biodegradable material holding said separation region together during expansion and which biodegradable material degrades in a physiologic environment, allowing said separation region to separate after expansion.

3 . An endoluminal prosthesis as in claim 2 , wherein the biodegradable polymer and/or adhesive comprises polylactide, poly-L-lactide, poly-DL-lactide, polylactide-co-glycolide, poly(L-lactic-co-glycolide), poly(ethylene-co-vinyl acetate), poly(L-lactide-co-epsilon-caprolactone), poly(DL-lactide-co-glycolide), poly(lactide-co-caprolactone), poly(D-lactide), polyglycolide, polycaprolactone, polyhydroxyalkanoate, polyvinyl alcohol, polyvinyl acetate or cyanoacrylate.

4 . An endoluminal prosthesis as in claim 1 , wherein all circumferential rings are axially joined by one or more axial links and wherein at least some said circumferential rings remain axially joined after all discontinuities are formed

5 . An endoluminal prosthesis as in claim 4 , wherein all axial links remain substantially intact after expansion in a physiologic environment.

6 . An endoluminal prosthesis as in claim 1 , wherein said first free end comprises a lock and said second free end comprises a key.

7 . An endoluminal prosthesis as in claim 6 , wherein said lock and key comprises male and female portions, wherein said male portion fits into a slot or channel between two arms of the female portion.

8 . An endoluminal prosthesis as in claim 7 , wherein the length of the male portion and slot or channel of the female portion are longer than the width of said strut containing said male and female portions.

9 . An endoluminal prosthesis as in claim 1 , wherein said at least one separation region is in a strut which joins two crowns on one circumferential ring.

10 . An endoluminal prosthesis of claim 1 , wherein the scaffold separates into two or more axially joined segments after all discontinuities are formed

11 . An endoluminal prosthesis as in claim 10 , wherein at least some of the two or more segments circumferentially separate along separation lines which extend from a first end of the scaffold to a second end of the scaffold,

12 . An endoluminal prosthesis as in claim 11 , wherein the separation lines have axial or spiral geometries along the length of the scaffold.

13 . An endoluminal prosthesis as in claim 1 , wherein the struts, crowns and said held-together separation region of said at least some of the circumferential rings provide a continuous perimeter around the scaffold and adjacent rings are axially joined.

14 . An endoluminal prosthesis as in claim 1 , wherein at least some of the circumferential rings have a discontinuous perimeter with end regions which join to form a helical scaffold.

15 . An endoluminal prosthesis as in claim 1 , wherein said prosthesis has an open cell, closed cell, or helical backbone design,

16 . An endoluminal prosthesis as in claim 1 , wherein each circumferential ring has from one to five struts having a separation region.

17 . An endoluminal prosthesis as in claim 1 , wherein all crowns of at least some circumferential rings are free from separation regions

18 . An endoluminal prosthesis as in claim 1 , wherein the discontinuities in the circumferential rings are configured to allow the scaffold to further expand after inward recoil from an initial expansion in a physiologic environment.

19 . An endoluminal prosthesis as in claim 1 , wherein the struts and crowns of at least some of the circumferential rings form a continuous circumferential path in each of said circumferential rings, and wherein the separation regions, located within at least some of the circumferential rings, form discontinuities in each of the said paths after expansion in a physiologic environment providing a discontinuous circumferential path in each of said at least some circumferential rings.

20 . An endoluminal prosthesis as in claim 1 , wherein said prosthesis comprises at least one coating on at least one surface of said prosthesis.

21 . An endoluminal prosthesis as in claim 1 , wherein said prosthesis comprises at least one drug on at least one surface of said prosthesis.

22 . An endoluminal prosthesis as in claim 21 , wherein said at least one drug comprising an m-TOR inhibitor comprising sirolimus, novolimus, biolimus, everolimus, ridaforolimus, temsirolimus, or zotarolimus.

23 . An endoluminal prosthesis as in claim 1 , wherein at least two adjacent rings are connected though an axial link between a crown on one of said two adjacent rings and a crown on the other of said two adjacent rings, and wherein none of the struts connected to said crowns comprises a separation region.

24 . An endoluminal prosthesis as in claim 1 , wherein at least two adjacent rings are connected though an axial link between a crown on one of said two adjacent rings and a crown on the other of said at two adjacent rings, wherein at least one of the struts connected to said crowns comprises a separation region

25 . An endoluminal prosthesis as in claim 1 , wherein said free ends comprise a male portion and a female portion, a ball and socket, disc and cap, interlocking combs, interlocking teeth or wavy or undulating interlocking surfaces.

26 . An endoluminal prosthesis as in claim 1 , wherein said separation regions of said circumferential rings have a random pattern or are rotationally offset between circumferential rings.

Assignees

• Elixir Medical Corp

Inventors

• Sirhan Motasim
• Yan John
• Bhat Vinayak
• Paraschac Joseph
• Cryer Brett
• Serna Benjamyn

Classifications

• A61F2002/075

  the stent being loosely attached to the graft material, e.g. by stitching · CPC title

• A61F2/90

  characterised by a net-like or mesh-like structure · CPC title

• A61F2/915 Primary

  with bands having a meander structure, adjacent bands being connected to each other · CPC title

• A61F2/89 Primary

  the wire-like elements comprising two or more adjacent rings flexibly connected by separate members · CPC title

• A61F2230/0069

  cylindrical · CPC title