Telemedicine system using artificial intelligence-based neurofeedback and method for operating same

Patent metadata

Field	Value
Publication number	US-2023200730-A1
Application number	US-202118008311-A
Country	US
Kind code	A1
Filing date	Jun 11, 2021
Priority date	Jun 12, 2020
Publication date	Jun 29, 2023
Grant date	—

Abstract

A telemedicine system according to one embodiment includes a gateway for transmitting monitoring information including a stimulation signal and a biosignal corresponding to the stimulation signal to a cloud; and a server for extracting the stimulation signal and the biosignal from the transmitted monitoring information, providing the extracted stimulation signal and biosignal as inputs of a pre-stored artificial intelligence machine learning algorithm-based stimulation control model, regenerating the biosignal as an output of the stimulation control model into a stimulation signal to be regulated for the balance between sympathetic and parasympathetic nerves, and feeding back the regenerated stimulation signal to a personalized vagus nerve stimulation and pulse electromagnetic field treatment device, wherein the monitoring information includes a biosignal measured when vagus nerves are stimulated in the form of electromagnetism at a stimulation site based on a stimulation signal generated from the personalized vagus nerve stimulation and pulse electromagnetic field treatment device, and the personalized vagus nerve stimulation and pulse electromagnetic field treatment device newly stimulates vagus nerves with the feedback stimulation signal.

First claim

1 . A telemedicine system, comprising:
a gateway for transmitting monitoring information comprising a stimulation signal and a biosignal corresponding to the stimulation signal to a cloud; and a server for extracting the stimulation signal and the biosignal from the transmitted monitoring information, providing the extracted stimulation signal and biosignal as inputs of a pre-stored artificial intelligence machine learning algorithm-based stimulation control model, regenerating the biosignal as an output of the stimulation control model into a stimulation signal to be regulated for balance between sympathetic and parasympathetic nerves, and feeding back the regenerated stimulation signal to a personalized vagus nerve stimulation and pulse electromagnetic field treatment device, wherein the monitoring information comprises a biosignal measured when vagus nerves are stimulated in a form of electromagnetism at a stimulation site based on a stimulation signal generated from the personalized vagus nerve stimulation and pulse electromagnetic field treatment device, and the personalized vagus nerve stimulation and pulse electromagnetic field treatment device newly stimulates vagus nerve with the feedback stimulation signal.

2 . The telemedicine system according to claim 1 , further comprising a medical staff terminal for outputting information comprising at least one of the measured biosignal and the regenerated stimulation signal,
wherein the regenerated stimulation signal is updated based on electroceutical prescription information generated according to the information output from the medical staff terminal.

3 . A personalized vagus nerve stimulation and pulse electromagnetic field treatment device, comprising:
a stimulator for generating, based on a stimulation signal, at least one of electrical stimulation that stimulates vagus nerves in a form of cranial electrotherapy stimulation (CES) at two or more stimulation sites located on an auricle and an earlobe, respectively, electrical stimulation that stimulates vagus nerves in a form of transcutaneous electrical nerve stimulation (TENS) at two or more stimulation sites located in bilateral carotid arteries of a neck, and a magnetic field that stimulates vagus nerves in a form of pulsed electromagnetic field (PEMF) at stimulation sites located around a brain from a heart; a biosignal monitor for measuring a biosignal that responds to stimulation applied to the vagus nerve and outputting monitoring information comprising the stimulation signal and the biosignal through an artificial intelligence encoder; and a communicator for transmitting the output monitoring information to a mobile terminal or a server using short-range wireless communication, wherein the stimulator receives a regenerated stimulation signal fed back from the mobile terminal or the server based on a stimulation control model and regenerates electrical stimulation or a magnetic field.

4 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the stimulation control model determines whether interaction between a heart and a brain or an autonomic nervous system is abnormal based on variability of a time interval between adjacent heartbeats using heart rate variability (HRV) measured from the biosignal, or
determines whether the autonomic nervous system is abnormal by determining a degree of maintaining blood pressure homeostasis using baroreflex sensitivity (BRS) measured from the biosignal, and regenerates the stimulation signal in real time.

5 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the biosignal monitor monitors a brain response by electroencephalogram (EEG) as the biosignal, and encodes and outputs frontal lobe activation information according to the brain response through an artificial intelligence encoder.

6 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the biosignal monitor monitors a nerve response by photoplethysmography (PPG) measured from at least one of an ear, a neck, and a wrist as the biosignal, and encodes and outputs autonomic nerve information according to the nerve response through an artificial intelligence encoder.

7 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the biosignal monitor monitors a body response by physical activity measurement (Actigraph) measured from at least one of an ear, a neck, and a wrist as the biosignal, and encodes and outputs movement information according to the body response through an artificial intelligence encoder.

8 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the stimulator generates electrical stimulation at an intensity of 0 to 20 mA, a frequency band of 0 to 1,000 Hz, and a pulse width of 0 to 1,000 μS or a magnetic field at a frequency band of 0 to 1,000 Hz and a pulse width of 0 to 1,000 μS.

9 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the mobile terminal transmits the output monitoring information to a server,
the server extracts the stimulation signal and a biosignal that responds according to the stimulation signal from the transmitted monitoring information, provides the extracted stimulation signal and biosignal as inputs of a pre-stored artificial intelligence machine learning algorithm-based stimulation control model, regenerates the biosignal as an output of the stimulation control model into a stimulation signal to be regulated for balance between sympathetic and parasympathetic nerves, and feeds back the regenerated stimulation signal to the communicator, and the stimulator newly generates electrical stimulation or a magnetic field as the feedback stimulation signal.

10 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the mobile terminal extracts the stimulation signal and a biosignal that responds according to the stimulation signal from the output monitoring information, provides the extracted stimulation signal and biosignal as inputs of a pre-stored artificial intelligence machine learning algorithm-based stimulation control model, regenerates the biosignal as an output of the stimulation control model into a stimulation signal to be regulated for balance between sympathetic and parasympathetic nerves, and feeds back the regenerated stimulation signal to the communicator, and
the stimulator newly generates electrical stimulation or a magnetic field as the feedback stimulation signal.

11 . The personalized vagus nerve stimulation and pulse electromagnetic field treatment device according to claim 3 , wherein the mobile terminal downloads or periodically updates the stimulation control model from the server.

12 . A server, comprising:
a monitoring information collector for collecting monitoring information comprising a biosignal measured when a stimulation signal is generated from a personalized vagus nerve stimulation and pulse electromagnetic field treatment device, and at least one of stimulation of vagus nerves in a form of cranial electrotherapy stimulation (CES) at two or more stimulation sites located on an auricle and an earlobe, respectively, stimulation of vagus nerves in a form of transcutaneous electrical nerve stimulation (TENS) at two or more stimulation sites located in bilateral carotid arteries of a neck, and a magnetic field that stimulates vagus n

Assignees

• Univ Korea Res & Bus Found

Inventors

• Kim Dong Joo
• Kim Young Tak
• Kim Hyun Ji

Classifications

• A61N1/36053

  adapted for vagal stimulation (A61N1/36114 takes precedence) · CPC title

• A61N1/0456

  Specially adapted for transcutaneous electrical nerve stimulation [TENS] · CPC title

• A61N1/36025

  for treating a mental or cerebral condition · CPC title

• A61B5/4035

  Evaluating the autonomic nervous system · CPC title

• A61B5/02405

  Determining heart rate variability · CPC title