Device for delivering ionic material and method of controlling the same

Patent metadata

Field	Value
Publication number	US-2023140234-A1
Application number	US-202217731445-A
Country	US
Kind code	A1
Filing date	Apr 28, 2022
Priority date	Nov 4, 2021
Publication date	May 4, 2023
Grant date	—

Abstract

A device for delivering an ionic material includes a storage module including a reservoir configured to store the ionic material, a bipolar membrane configured to pass the ionic material in a single direction based on an ionic current, electrodes, disposed on a lower end of the reservoir and an upper end of the bipolar membrane, respectively, configured to form an electric field generating the ionic current, and a control module configured to control either one or both of a release amount and a release period of the ionic material passing through the bipolar membrane by adjusting a direction and an intensity of the electric field.

First claim

What is claimed is:

1 . A device for delivering an ionic material, the device comprising:
a storage module comprising a reservoir configured to store the ionic material; a bipolar membrane configured to pass the ionic material in a single direction based on an ionic current; electrodes, disposed on a lower end of the reservoir and an upper end of the bipolar membrane, respectively, configured to form an electric field generating the ionic current; and a control module configured to control either one or both of a release amount and a release period of the ionic material passing through the bipolar membrane by adjusting a direction and an intensity of the electric field.

2 . The device of claim 1 , wherein the control module is further configured to:
control the ionic material to be released through the bipolar membrane by generating the ionic current based on a forward bias voltage provided by applying a cathode voltage to a region adjacent to a cationic polymer of the bipolar membrane and applying an anode voltage to a region adjacent to an anionic polymer of the bipolar membrane through the electrodes.

3 . The device of claim 1 , wherein the control module is further configured to:
control the ionic material not to pass through the bipolar membrane by blocking generation of the ionic current by forming a depletion layer in a bonding portion of the bipolar membrane based on a reverse bias voltage provided by applying an anode voltage to a region adjacent to a cationic polymer of the bipolar membrane and applying a cathode voltage to a region adjacent to an anionic polymer of the bipolar membrane through the electrodes.

4 . The device of claim 1 , further comprising:
a sensing module configured to detect either one or both of an amount and a concentration of the ionic material in a human body into which the device is inserted.

5 . The device of claim 4 , wherein the control module is further configured to:
determine any one or any combination of any two or more of whether to release the ionic material, the release amount, and the release period of the ionic material according to a detection result of the sensing module; and adjust the direction and the intensity of the electric field based on a result of the determine.

6 . The device of claim 1 , wherein
the bipolar membrane comprises an anionic polymer having a first permeability to ions having same charges and a cationic polymer having a second permeability to ions having opposite charges, and the second permeability is greater than the first permeability.

7 . The device of claim 6 , wherein
the anionic polymer comprises one of sulfonated polyphenylene oxide, sulfonated polyethersulfone, sulfonated polyether ether ketone, sulfonated polystyrene, phosphorylated polyphenylene oxide, phosphorylated polysulfone, and carboxylated polyethylene, and the cationic polymer comprises one of quaternized polyphenylene oxide, quaternized polysulfone, imidazolated polyphenylene oxide, quaternized polyether ether ketone, amidated polyphenylene oxide, amidated polysulfone, and amidated polyether ether ketone.

8 . The device of claim 1 , further comprising:
a drug receptor accommodated in the reservoir, the drug receptor comprising the ionic material and any one or any combination of any two or more of phosphate-buffered saline, an aqueous sodium chloride solution, an agarose gel, an alginate gel, and a chitosan gel.

9 . The device of claim 1 , wherein
the storage module is further configured to store a cell generating and secreting a therapeutic factor, and the bipolar membrane is further configured to store or release the therapeutic factor based on the ionic current.

10 . The device of claim 1 , wherein the storage module comprises one of polybutylene adipate terephthalate (PBAT), polyurethane, polyethylene, polysulfone, polydimethylsiloxane, and polymethyl methacrylate.

11 . The device of claim 1 , wherein the electrodes comprise any one or any combination of any two or more of platinum, gold, stainless steel, silver, silver chloride, carbon, and oxides thereof.

12 . The device of claim 1 , further comprising:
a communication module configured to receive a control signal based on the release amount and the release period of the ionic material.

13 . The device of claim 1 , further comprising:
a wireless power reception module configured to wirelessly receive power inducing the electric field.

14 . The device of claim 1 , further comprising:
a power supply module configured to supply power inducing the electric field.

15 . A method of delivering an ionic material in a device, the method comprising:
detecting a concentration of the ionic material in a human body into which the device is inserted; comparing the concentration with a reference concentration; determining any one or any combination of any two or more of whether to release the ionic material and a release time, a release period, a release rate, and a release amount of the ionic material, based on a result of the comparing; and controlling either one or both of a direction and an intensity of an electric field of an ionic material carrier of the device based on the determining.

16 . The method of claim 15 , wherein the determining comprises:
determining to release the ionic material in response to the concentration being less than the reference concentration; and determining any one or any combination of any two or more of the release time, the release rate, and the release amount to release the ionic material in proportion to a difference between the concentration and the reference concentration.

17 . The method of claim 16 , wherein the controlling comprises controlling the direction of the electric field to form a forward bias with respect to the ionic material carrier in response to a determination to release the ionic material.

18 . The method of claim 15 , wherein the determining comprises determining to block a release of the ionic material in response to the concentration being greater than or equal to the reference concentration.

19 . The method of claim 18 , wherein the controlling comprises controlling the direction of the electric field to form a reverse bias with respect to the ionic material carrier in response to a determination to block the release of the ionic material.

20 . A non-transitory computer-readable storage medium storing instructions that, when executed by one or more processors, configure the one or more processors to perform the method of claim 15 .

Assignees

• Samsung Electronics Co Ltd
• Seoul Nat Univ R&Db Foundation

Inventors

• Kang Joonseong
• Kang Seung-Kyun
• Choi Sung-Geun
• Hong Young Jun
• Lee Don-Wook

Classifications

• B01D61/422

  Electrodialysis · CPC title

• A61M5/14248

  of the skin patch type · CPC title

• A61M5/14276 Primary

  specially adapted for implantation · CPC title

• A61M31/002

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title

• A61M2005/14208

  with a programmable infusion control system, characterised by the infusion program · CPC title