Mixture composition comprising glycolipids and triethyl citrate

Patent metadata

Field	Value
Publication number	US-2023121094-A1
Application number	US-202117905835-A
Country	US
Kind code	A1
Filing date	Mar 8, 2021
Priority date	Mar 11, 2020
Publication date	Apr 20, 2023
Grant date	—

Abstract

A composition contains glycolipids and Methyl citrate (TEC). The TEC can assist in stabilizing a foam of a corresponding aqueous composition. A method can be used for preparing a corresponding formulation, preferably a cosmetical or pharmaceutical formulation, by providing the composition and diluting the composition. The pH of the composition may be adjusted during the dilution by adding an organic or inorganic base

First claim

1 . A composition, comprising:
0.2% by weight to 70% by weight of at least one, glycolipid, 0.01% by weight to 14% by weight of triethyl citrate, and water, wherein the percentages by weight refer to the total composition wherein a weight ratio of all glycolipids to all triethyl citrate comprised in the composition is in a range of from 5:1 to 20:1.

2 . The composition according to claim 1 , wherein a pH of the composition at 25° C. is from 4.5 to 7.0.

3 . The composition according to claim 1 , wherein the composition comprises 40% by weight to 70% by weight of the at least one glycolipid, wherein the percentages by weight refer to the total composition.

4 The composition according to claim 1 wherein the composition comprises 0.2% by weight to 12% by weight of the at least one glycolipid, wherein the percentages by weight refer to the total coposition.

5 . The composition according to claim 1 , wherein said composition comprises 51% by weight to 95% by weight of diRL-C10C10, wherein the percentages by weight refer to a sum total of all rhamnolipids present.

6 . The composition according to claim 1 , wherein said composition comprises 0.5% by weight to 9% by weight of monoRL,C10C10, wherein the percentages by weight refer to a sum total of all rhamnolipids present.

7 . The composition accordine to claim 1 , wherein a weight ratio of all di-rhamnolipids present to all mono-rhamnolipids present is greater than 51:49.

8 . The composition according to claim 1 , wherein said composition comprises 0.5 to 25% by weight of diRL-C10C12, wherein the percentages by weight refer to a sum total of all rhamnolipids present.

9 . The composition according to claim 1 , wherein said composition comprises:
0.1% by weight to 5% by weight of monoRL-C10C12, and/or 0.1% by weight to 5% by weight of monoRL-C10C12:1, wherein the percentages by weight refer to a sum total of all rhamnolipids present

10 . The composition according to claim 1 , wherein said composition comprises:
0.5% by weight to 15% by weight of diRL-C10C12:1, 0.5 to 25% by weight of diRL-C10C12, 0.1% by weight to 5% by weight of monoRL-C10C12, and 0.1% by weight to 5% by weight of monoRL-C10C1 2:1, wherein the percentages by weight refer to a sum total of all rhamnolipids present

11 . The composition according to claim 1 wherein said composition comprises at least one preservative selected from the group consisting of p-anisic acid, levulinic acid, lactic acid, citric acid, and a salt of the aforementioned acids.

12 . A method for preparing a formulation of at least one glycolipid, the method comprising:
a) providing a composition comprising
40% by weight to 70 weight of at least one glycolipid,
2.0% by weight to 14% by weight of triethyl citrate, and water,
wherein the percentages by weight refer to the total composition, wherein a weight ratio of all glycolipids to all triethyl citrate comprised in the composition is in a range of from 5:1 to 20:1, and b) diluting the composition with at least partially water to a formulation comprising 0.2% by weight to 12% by weight of the at least one glycolipid, where the percentages by weight refer to the total formulation.

13 . The method according to claim 12 , wherein a pH of the formulation in b) is adjusted to a pH of at 25 20 C. from 4.5 to 7.0.

14 . A method, comprising:
adding triethyl citrate to an aqueous composition containing at least one glycolipid, to stabilize a foam of the aqueous composition.

15 . (canceled)

16 . The composition according to claim 1 , comprising:
0.4% by weight to 55% by weight of the at least one glycolipid, and 0.02% by weight to 11% by weight of triethyl citrate, wherein the percentages by weight refer to the total composition.

17 . The composition according to claim 9 , wherein the composition comprises:
0.1% by weight to 5% by weight of the monoRL-C10C12, and 0.1.% by weight to 5% by weight of the monoRL-C10C12:1, wherein the percentages by weight refer to the sum total of all rhamnolipids present.

18 . The composition according to claim 1 , wherein the composition comprises the at least one preservative at a concentration of from 0.01% by weight to 14% by weight, where the percentages by weight refer to the total composition.

19 . The method according to claim 12 , wherein the formulation is a cosmetical or pharmaceutical composition.

20 . The method according to claim 13 . wherein the pH of the formulation is adjusted in b) by adding an organic or inorganic base.

Assignees

• Evonik Operations Gmbh
• Evonik Dr Straetmans Gmbh

Inventors

• Brandt Kathrin Daniela
• Liebig Stefan Julian
• Wenk Hans Henning
• Salmina-Petersen Manuela
• Tölle Christoph
• Muss Alina

Classifications

• A61K8/602

  Glycosides, e.g. rutin · CPC title

• A61Q19/10

  Washing or bathing preparations · CPC title

• A61K8/37 Primary

  Esters of carboxylic acids · CPC title

• A61K8/60 Primary

  Sugars; Derivatives thereof · CPC title

• A61K8/046

  Aerosols; Foams · CPC title