Near-infrared fluorescent indicators for lysosome and application thereof

Patent metadata

Field	Value
Publication number	US-2023073652-A1
Application number	US-202217873248-A
Country	US
Kind code	A1
Filing date	Jul 26, 2022
Priority date	Jul 27, 2021
Publication date	Mar 9, 2023
Grant date	—

Abstract

The present disclosure relates to Near-infrared fluorescent indicators for lysosomes and application thereof. These indicators are composed of lipophilic NIR BODIPY derivatives and ionizable bis-tertiary amine moiety, which enable the formation of a transient amphiphilic state in acidic environments specifically. This structural feature affords accurate lysosomal membrane targeting ability at nanomole staining concentration.

First claim

What is claimed is:

1 . A compound of formula I:

Wherein, R 1 and R 2 are each independently H, Cl, Br or I;
R 3 is H, CH 3 , CF 3 , C 3 H 6 COOCH3, C 2 H 4 COOC 2 H 5 , C 2 H 5 ,

X 1 is

X 2 is H or

Y is each independently

2 . A composition targeting lysosomes comprising a compound of claim 1 .

3 . A composition tracking lysosomes comprising a compound of claim 1 .

Assignees

• Univ Dalian Tech

Inventors

• Zhang Xinfu
• Xiao Yi
• Li Xiangli

Classifications

• C09K11/06

  containing organic luminescent materials · CPC title

• C09B23/04

  one >CH- group, e.g. cyanines, isocyanines, pseudocyanines · CPC title

• C07F5/022 Primary

  without C-boron linkages · CPC title

• C07D517/14 Primary

  Ortho-condensed systems · CPC title

• C07D209/58

  [b]- or [c]-condensed · CPC title