Tandem bio-organic light-emitting diode for photodynamic therapy and photodynamic apparatus comprising same

Patent metadata

Field	Value
Publication number	US-2023046173-A1
Application number	US-202117758283-A
Country	US
Kind code	A1
Filing date	Aug 6, 2021
Priority date	Nov 20, 2020
Publication date	Feb 16, 2023
Grant date	—

Abstract

The present invention is directed to a tandem-structured bio-organic light emitting diode (bio-OLED) for photodynamic therapy, and to a photodynamic therapy device including the same to convert a red light emitted from the bio-organic light emitting diode into a near-infrared light (NIR) emission, thereby enabling the use of a PBM therapy in a wide wavelength range of 600 to 1,000 nm.

First claim

1 . A tandem-structured bio-organic light emitting diode for photodynamic therapy comprising:
a first electrode layer; a second electrode layer formed to face the first electrode layer; an organic light emitting diode unit (OLED unit) layer disposed between the first electrode layer and the second electrode layer and emitting a red light (RED); and a charge generation layer (CGL) disposed between each organic light emitting diode unit layer, wherein at least two or more organic light emitting diode unit layers are formed between the first electrode layer and the second electrode layer.

2 . The tandem-structured bio-organic light emitting diode for photodynamic therapy of claim 1 , wherein the organic light emitting diode unit layer emits a broadband emission spectrum with a full width at half maximum of about 80 nm or more.

3 . The tandem-structured bio-organic light emitting diode for photodynamic therapy of claim 1 , wherein the organic light emitting diode unit layer comprises: a hole injection layer (HIL) formed on the first electrode layer, a hole transport layer (HTL) formed on the hole injection layer, an emission layer (EML) formed on the hole transport layer and emitting a red light (RED), a hole block layer (HBL) formed on the emission layer, an electron transport layer (ETL) formed on the hole block layer, and an electron injection layer (EIL) formed on the electron transport layer, and
the hole injection layer is formed to a thickness in a range of 1 to 150 nm, and the hole transport layer is formed to a thickness in a range of 1 to 50 nm.

4 . A photodynamic therapy device comprising a tandem-structured bio-organic light emitting diode, comprising:
(A) an encapsulation substrate layer, (B) a tandem-structured bio-organic light emitting diode (bio-OLED) layer comprising a first electrode layer on the encapsulation substrate layer; a second electrode layer formed to face the first electrode layer; at least two or more organic light emitting diode unit (OLED unit) layers disposed between the first electrode layer and the second electrode layer and emitting a red light (RED); and a charge generation layer (CGL) disposed between each organic light emitting diode unit layer, (C) a transparent encapsulation substrate layer formed on the bio-organic light emitting diode layer, and (D) a light conversion layer on, or on and below the transparent encapsulation substrate layer, wherein the light conversion layer converts the red light emitted from the bio-organic light emitting diode layer into a near-infrared (NIR) emission.

5 . The photodynamic therapy device comprising the tandem-structured bio-organic light emitting diode of claim 4 , wherein the photodynamic therapy device emits a red light and a near-infrared light (NIR) or emits only a near-infrared light (NIR).

6 . The photodynamic therapy device comprising the tandem-structured bio-organic light emitting diode of claim 4 , wherein the photodynamic therapy device comprises a near-infrared-light-pass dichroic filter (NIR-pass-dichroic filter, NPD) layer on the light conversion layer; or comprises the NPD layer on the light conversion layer and a red-light-pass dichroic filter (RPD) layer below the light conversion layer.

7 . The photodynamic therapy device comprising the tandem-structured bio-organic light emitting diode of claim 6 , wherein the NPD layer and the RPD layer are each formed as a unit in which a low refractive index layer and a high refractive index layer are repeated.

8 . The photodynamic therapy device comprising the tandem-structured bio-organic light emitting diode of claim 4 , wherein the light conversion layer comprises an adhesive polymer layer; and quantum dots (QD), a dye or a mixture of quantum dots and dye as a light conversion material formed on the adhesive polymer layer.

9 . A tandem-structured bio-organic light emitting diode array for photodynamic therapy, comprising:
a plurality of bio-organic light emitting diodes (bio-OLEDs) comprising: a first electrode layer; a second electrode layer formed to face the first electrode layer; at least two or more organic light emitting diode unit (OLED unit) layers disposed between the first electrode layer and the second electrode layer and emitting a red light (RED); and a charge generation layer (CGL) disposed between each organic light emitting diode unit layer, wherein a light conversion layer comprising a light conversion material for converting the red light into a near-infrared light (NIR) is formed on a part of or all of the plurality of bio-organic light emitting diodes.

10 . The tandem-structured bio-organic light emitting diode array of claim 9 , emitting a red light and a near-infrared light in a wide wavelength range of 600 to 1,000 nm.

11 . The photodynamic therapy device comprising the tandem-structured bio-organic light emitting diode of claim 4 , wherein the organic light emitting diode unit layers emit a broadband emission spectrum with a full width at half maximum of about 80 nm or more.

12 . The photodynamic therapy device comprising the tandem-structured bio-organic light emitting diode of claim 4 , wherein the organic light emitting diode unit layers comprise: a hole injection layer (HIL) formed on the first electrode layer, a hole transport layer (HTL) formed on the hole injection layer, an emission layer (EML) formed on the hole transport layer and emitting a red light (RED), a hole block layer (HBL) formed on the emission layer, an electron transport layer (ETL) formed on the hole block layer, and an electron injection layer (EIL) formed on the electron transport layer, and
the hole injection layer is formed to a thickness in a range of 1 to 150 nm, and the hole transport layer is formed to a thickness in a range of 1 to 50 nm.

13 . The tandem-structured bio-organic light emitting diode array of claim 9 , wherein the organic light emitting diode unit layers emit a broadband emission spectrum with a full width at half maximum of about 80 nm or more.

14 . The tandem-structured bio-organic light emitting diode array of claim 9 , wherein the organic light emitting diode unit layers comprise: a hole injection layer (HIL) formed on the first electrode layer, a hole transport layer (HTL) formed on the hole injection layer, an emission layer (EML) formed on the hole transport layer and emitting a red light (RED), a hole block layer (HBL) formed on the emission layer, an electron transport layer (ETL) formed on the hole block layer, and an electron injection layer (EIL) formed on the electron transport layer, and
the hole injection layer is formed to a thickness in a range of 1 to 150 nm, and the hole transport layer is formed to a thickness in a range of 1 to 50 nm.

15 . The tandem-structured bio-organic light emitting diode array of claim 9 , wherein the light conversion layer comprises an adhesive polymer layer; and quantum dots (QD), a dye or a mixture of quantum dots and dye as a light conversion material formed on the adhesive polymer layer.

Assignees

• Dslab Inc
• Research & Business Found Sungkyunkwan Univ

Inventors

• Jo Deok Su
• Chung Ho Kyoon
• Cho Sung Min
• Kim Min Jung
• Dang Thi My Linh
• Tran Thien Tri

Classifications

• A61N2005/0653

  Organic light emitting diodes · CPC title

• A61N2005/0659

  infrared · CPC title

• A61N5/062 Primary

  Photodynamic therapy, i.e. excitation of an agent · CPC title

• A61N2005/0652

  Arrays of diodes · CPC title

• A61N2005/0662

  Visible light · CPC title