Thin, soft, skin-mounted microfluidic networks for detection and analysis of targets of interest in sweat
US-2020093416-A1 · Mar 26, 2020 · US
US2023031505A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2023031505-A1 |
| Application number | US-202017784135-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 10, 2020 |
| Priority date | Dec 10, 2019 |
| Publication date | Feb 2, 2023 |
| Grant date | — |
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There is provided a method of forming a thin film-based microfluidic electronic device. The method includes: providing a first elastomeric thin film layer on a substrate; depositing a first elastomer on the first elastomeric thin film by direct ink writing to form an elastomeric structure configured to define a microfluidic channel on the first elastomeric thin film layer; providing a second elastomeric thin film layer over the elastomeric structure to cover the microfluidic channel; providing a sacrificial layer on the second elastomeric thin film; depositing liquid metal into the microfluidic channel to form a conductor in the microfluidic channel; and electrically connecting the conductor to an electronic component. The thin film-based microfluidic electronic device is a tissue or skin adhesive sensor including a skin adhesive acoustic device.
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1 . A method of forming a thin film-based microfluidic electronic device, the method comprising: providing a first elastomeric thin film layer on a substrate; depositing a first elastomer on the first elastomeric thin film by direct ink writing to form an elastomeric structure configured to define a microfluidic channel on the first elastomeric thin film layer; providing a second elastomeric thin film layer over the elastomeric structure to cover the microfluidic channel; providing a sacrificial layer on the second elastomeric thin film layer; depositing liquid metal into the microfluidic channel to form a conductor in the microfluidic channel; and electrically connecting the conductor to an electronic component. 2 . The method according to claim 1 , wherein the first elastomer comprises an elastomeric adhesive material. 3 . The method according to claim 2 , wherein the elastomeric adhesive material comprises a silicone sealant. 4 . The method according to claim 3 , wherein the first elastomeric thin film layer and the second thin film layer of the elastomer comprises silicone elastomers. 5 . The method according to claim 1 , wherein the sacrificial layer comprises a liquid soluble layer. 6 . The method according to claim 5 , further comprising removing the sacrificial layer after depositing the liquid metal into the microfluidic channel by dissolving the sacrificial layer in a liquid. 7 . The method according to claim 1 , further comprising embedding a portion of the electronic component in a portion of the elastomeric structure during formation of the elastomeric structure. 8 . The method according to claim 7 : wherein said embedding a portion of the electronic component in a portion of the elastomeric structure comprises disposing the electronic component on a portion of the first elastomer; and further comprising depositing a second elastomer over the first elastomer and the electronic component by direct ink writing to form the elastomeric structure having the electronic component embedded in a portion of elastomeric structure. 9 . The method according to claim 1 , further comprising embedding a portion of a conductive element in the microfluidic channel during formation of the elastomeric structure, the conductive element configured to electrically connect the conductor and the electronic component. 10 . The method according to claim 1 , wherein the electronic component comprises an integrated circuit chip. 11 . The method according to claim 1 , wherein the electronic component comprises light emitting diode (LED) chips. 12 . The method according to claim 1 , wherein the elastomeric structure is configured to define the microfluidic channel having a shape of a coil; and said depositing liquid metal into the microchannel forms an antenna coil in the microfluidic channel. 13 . The method according to claim 1 , wherein the liquid metal comprises a Gallium-based liquid metal alloy. 14 . The method according to claim 13 , wherein the Gallium-based liquid metal alloy comprises Galinstan. 15 . The method according to claim 1 , wherein said providing a first elastomeric thin film layer further comprises: forming a supporting layer on a base; depositing uncured elastomer on the base; performing thermal treatment on the uncured elastomer to form the first elastomeric thin film layer; forming a support frame on the first elastomeric thin film layer; and removing the supporting layer from the first elastomeric thin film layer, the first elastomeric thin film layer being free standing. 16 . The method according to claim 1 , wherein said providing a first elastomeric thin film layer on a substrate comprises spin coating uncured elastomer on the substrate and performing thermal treatment to the uncured elastomer to form the first elastomeric thin film layer. 17 . The method according to claim 1 , further comprising removing the substrate from the first elastomeric thin film layer to form a free-standing thin film-based microfluidic electronic device. 18 . The method according to claim 17 , further comprising coating the free-standing thin film-based microfluidic electronic device with a bio-adhesive material for attaching the free-standing thin film-based microfluidic electronic device to a tissue. 19 . The method according to claim 1 , further comprising: providing a skin-adhesive patch on the substrate; said providing a first elastomeric thin film layer on a substrate comprises providing the first elastomeric thin film layer on the skin-adhesive patch; and removing the substrate from the skin-adhesive patch and the first elastomeric thin film layer from to form a free-standing skin-adhesive thin film-based microfluidic electronic device. 20 . A thin film-based microfluidic electronic device formed according to the method of claim 1 . 21 - 22 . (canceled)
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