Sustained release of antiinfectives

Patent metadata

Field	Value
Publication number	US-2023008563-A1
Application number	US-202217930931-A
Country	US
Kind code	A1
Filing date	Sep 9, 2022
Priority date	Oct 29, 2002
Publication date	Jan 12, 2023
Grant date	—

Abstract

Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 µm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75: 1 or less, or about 0.50: 1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.

First claim

1 - 32 . (canceled)

33 . A lipid antiinfective formulation comprising a lipid formulation and an antiinfective, wherein the lipid to antiinfective ratio is 1:1 or less.

34 - 52 . (canceled)

53 . A method of preparing a lipid antiinfective formulation comprising a lipid formulation and an antinfective comprising: mixing a stream of a lipid solution or mixture, with a stream of an antiinfective solution or mixture, wherein the two streams are mixed in line.

54 - 92 . (canceled)

Assignees

• Insmed Inc

Inventors

• Boni Lawrence T
• Miller Brian S
• Malinin Vladimir
• Li Xingong

Classifications

• A61K31/545 Primary

  Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: [IMAGE cpc-sch-A61K-0953.gif] , e.g. cephalosporins, {cefaclor, or cephalexine} · CPC title

• A61K31/704

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K47/28 Primary

  Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid · CPC title

• A61K9/0078

  for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions · CPC title