Use of synaptotagmin-7 in the diagnosis and treatment of bipolar disorder

Patent metadata

Field	Value
Publication number	US-2023003717-A1
Application number	US-202117794541-A
Country	US
Kind code	A1
Filing date	Jan 22, 2021
Priority date	Jan 22, 2020
Publication date	Jan 5, 2023
Grant date	—

Abstract

Provided is a biomarker for bipolar disorder, comprising Syt7 gene and/or an expression product thereof. Also provided is use of the Syt7 gene and/or the expression product thereof in the preparing a medicament for treating bipolar disorder. By monitoring the Syt7 gene and/or the expression product thereof, medicaments for treating bipolar disorder can be screened, thus providing support for diagnosis and treatment targeting Syt7 molecules.

First claim

1 . (canceled)

2 . A method for preparing a medicament for treating bipolar disorder and/or a complication thereof, wherein the medicament comprising Syt7 gene and/or an expression product thereof.

3 . The method according to claim 2 , wherein the medicament is capable of increasing an expression level of the Syt7 gene.

4 . A bipolar disorder cell model, comprising a reduced amount of Syt7 gene and/or an expression product thereof as compared to a wild-type cell.

5 . A bipolar disorder animal model, comprising a reduced amount of Syt7 gene and/or an expression product thereof as compared to a wild-type animal.

6 . The bipolar disorder animal model according to claim 5 , wherein the animal includes at least one selected from a mouse, a rat and a primate.

7 . A method for screening a medicament for treating bipolar disorder, comprising:
administering medicament candidates to the bipolar disorder cell model according to claim 4 ; selecting a medicament candidate causing an increase in an amount of the Syt7 gene or the expression product thereof, or selecting a medicament candidate causing alleviation in symptoms of bipolar disorder, as the medicament for treating bipolar disorder.

8 . (canceled)

9 . (canceled)

10 . A system for diagnosing bipolar disorder or determining a prognostic outcome for bipolar disorder, comprising:
an acquisition device for acquiring an amount of Syt7 gene or an expression product thereof in a biological sample; and a determination device connected with the acquisition device for diagnosing bipolar disorder or determining the prognostic outcome for bipolar disorder based on the amount of the Syt7 gene or the expression product thereof in the biological sample.

11 . The system according to claim 10 , wherein the determination device further comprises:
the amount of the Syt7 gene or the expression product thereof in the biological sample being lower than an amount of the Syt7 gene or the expression product thereof in a normal sample, is an indication that the biological sample has bipolar disorder; or the amount of the Syt7 gene or the expression product thereof in the biological sample being at least not lower than the amount of the Syt7 gene or the expression product thereof in the normal sample, is an indication of good prognostic outcome in a patient with bipolar disorder.

12 . A method for diagnosing bipolar disorder in a subject, comprising: detecting Syt7 gene and/or an expression product thereof in a biological sample from the subject.

13 . A method for screening a medicament for treating bipolar disorder, comprising:
administering medicament candidates to the bipolar disorder animal model according to claim 5 ; selecting a medicament candidate causing an increase in an amount of the Syt7 gene or the expression product thereof, or selecting a medicament candidate causing alleviation in symptoms of bipolar disorder, as the medicament for treating bipolar disorder.

14 . A method according to claim 13 , wherein the animal includes at least one selected from a mouse, a rat and a primate.

Assignees

• Univ Tsinghua

Inventors

• Yao Jun
• Shen Wei
• Wang Qiuwen
• Liu Yaonan

Classifications

• A01K2227/105

  Murine · CPC title

• A01K2217/075

  inducing loss of function, i.e. knock out · CPC title

• A01K67/0276

  Knock-out vertebrates · CPC title

• A61P25/18

  Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title

• G01N2800/52

  Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title