Compositions and methods with a probiotic and a nutrient and/or mineral for the prevention or treatment of mastitis

Patent metadata

Field	Value
Publication number	US-2022409679-A1
Application number	US-202017756570-A
Country	US
Kind code	A1
Filing date	Nov 27, 2020
Priority date	Nov 29, 2019
Publication date	Dec 29, 2022
Grant date	—

Abstract

The invention provides a mix or a nutritional composition comprising a probiotic Lactobacillus Fermentum CECT-5716 and a nutrient selected from the group consisting of beta-carotene, fiber, Vitamin C, Folate, Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6, Vitamin B12 and Potassium, or combination of two of more thereof, for use in treating or preventing mastitis, especially subclinical mastitis, in a subject, preferably a pregnant or lactating woman.

First claim

1 . A method for use in treating or preventing mastitis in a subject comprising administering a mix comprising a probiotic Lactobacillus Fermentum CECT-5716 and a nutrient selected from the group consisting of: beta-carotene, fiber, Vitamin C, Folate, Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6, Vitamin B12 or Potassium and a combination of two of more thereof to the subject.

2 . The method according to claim 1 which is a combination of nutrients comprising fiber and folate.

3 . The method according to claim 1 which is a combination of nutrients comprising fiber and one vitamin selected from the group consisting of: Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6 and Vitamin B12.

4 . The method according to claim 1 which is a combination of nutrients comprising folate and one vitamin selected from the group consisting of: Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6 and Vitamin B12.

5 . The method according to claim 1 , which is a combination of nutrients comprising fiber, folate and one vitamin selected from the group consisting of: Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6 and Vitamin B12.

6 . The method according to claim 1 , wherein the nutrient is in combination with one or more further nutrients selected from the group consisting of beta-carotene, fiber, Vitamin C, Folate, Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6, Vitamin B12 and Potassium.

7 . The method according to claim 1 , wherein the nutrient is in combination with vitamin E.

8 . The method according to claim 1 , wherein the combination further comprises a mineral selected from the group consisting of: iron, manganese, magnesium, copper, zinc and selenium.

9 . The method according to claim 1 , wherein the nutrient is in combination with:
(a) an n-3 fatty acid, preferably wherein the nutrient is in combination with a fatty acid selected from the group consisting of docosahexaenoic acid (DHA) and 18:3 n-3 octadecatrienoic acid (alpha-linolenic acid); (b) a protein selected from the group consisting of alpha-lactalbumin, lactoferrin and albumin; and/or phosphatidylcholine and/or lecithin.

10 . The method according to claim 1 , wherein the mix is in the form of a nutritional composition.

11 . The method according to claim 1 , wherein the mastitis is sub-clinical mastitis or clinical mastitis, preferably sub-clinical mastitis.

12 . The method according to claim 1 , wherein the subject is at risk of suffering from sub-clinical mastitis or clinical mastitis.

13 . The method according to claim 1 , wherein the treatment or prevention increases the probability of initiating and/or continuing breastfeeding by the subject; and/or increases the probability of the subject exclusively breast-feeding her infant and/or increases the duration of breastfeeding of the subject.

14 . The method according to claim 1 , wherein the subject continues to breast-feed for at least 4 months.

15 . The method according to claim 1 , wherein the treatment or prevention increases the quality and/or quantity of the subject's breast milk.

16 . The method according to claim 1 in a subject who is a lactating woman.

17 - 18 . (canceled)

Assignees

• Nestle Sa

Inventors

• Samuel Tinu Mary

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K33/26

  Iron; Compounds thereof · CPC title

• A61K31/525

  Isoalloxazines, e.g. riboflavins, vitamin B2 · CPC title

• A61K33/32

  Manganese; Compounds thereof · CPC title

• A23L33/135

  Bacteria or derivatives thereof, e.g. probiotics · CPC title