Method for making solid silica spheres

Patent metadata

Field	Value
Publication number	US-2022409538-A1
Application number	US-202217823750-A
Country	US
Kind code	A1
Filing date	Aug 31, 2022
Priority date	May 3, 2019
Publication date	Dec 29, 2022
Grant date	—

Abstract

The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS

First claim

1 . (canceled)

2 . The method of claim 18 , wherein the hollow silica spheres are prepared by a process comprising hydrolysis of a mixture comprising Fe 3 O 4 and phenyl-tri-methoxysilane (“PTMS”) followed by condensation with a hydroxide base.

3 . The method of claim 18 , wherein the Fe—HSS are not calcined.

4 . The method of claim 18 , wherein the Fe—HSS are calcined.

5 . The method of claim 18 , wherein the surfaces of the Fe—HSS are substantially free of phenyl or aryl groups.

6 . (canceled)

7 . (canceled)

8 . (canceled)

9 . (canceled)

10 . (canceled)

11 . (canceled)

12 . (canceled)

13 . (canceled)

14 . The method of claim 18 , wherein the Fe—HSS have average diameters ranging from 415 to 615 nm.

15 . The method of claim 18 , wherein the Fe—HSS comprises Fe 3 O 4 particles having an average diameter ranging from 9.5 nm to 21.3 nm.

16 . The method of claim 15 , wherein the Fe 3 O 4 particles are crystalline and present in an amount ranging from 0.1 to 10 wt % of a combined weight of the HSS and Fe 3 O 4 in the Fe—HSS.

17 . (canceled)

18 . A method for forming hollow silica spheres incorporating Fe 3 O 4 (“Fe—HSS”) comprising:
dissolving a hydrolyzable aryl silane in an aqueous solution comprising Fe 3 O 4 , water and an acid to form a hydrolyzed silane solution, wherein a molar ratio of the hydrolysable aryl silane to the Fe 3 O 4 ranges from 100:1;
mixing the hydrolyzed silane solution with a hydroxide base to form a precipitate; and
recovering Fe—HSS from the precipitate.

19 . The method of claim 18 , wherein the hydrolyzable aryl silane is trimethoxy(phenyl) silane and the hydroxide base is NH 4 OH.

20 . The method of claim 18 , wherein the precipitate is not calcined.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Bozkurt Ayhan
• Anil Seyda Tugba Gunday
• Khan Firdos Alam
• Akhtar Sultan

Classifications

• A61K9/0043

  Nose · CPC title

• A61K33/00

  Medicinal preparations containing inorganic active ingredients · CPC title

• A61K9/16 Primary

  Agglomerates; Granulates; Microbeadlets {; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction (A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51)} · CPC title

• A61K33/26

  Iron; Compounds thereof · CPC title

• A61K9/5115

  Inorganic compounds · CPC title