Disease diagnosis device and diagnosis method thereof

Patent metadata

Field	Value
Publication number	US-2022369952-A1
Application number	US-202217735343-A
Country	US
Kind code	A1
Filing date	May 3, 2022
Priority date	May 24, 2021
Publication date	Nov 24, 2022
Grant date	—

Abstract

Disclosed are a disease diagnosis device and a diagnosis method thereof. The disease diagnosis device includes a pump for pumping a respiratory gas, a first pre-treatment portion connected to the pump and removing moisture and bad breath in the respiratory gas, and a volatile organic compound (VOC) detection portion connected between the first pre-treatment portion and the pump to detect VOCs in the respiratory gas.

First claim

What is claimed is:

1 . A disease diagnosis device comprising:
a pump configured to pump a respiratory gas; a first pre-treatment portion connected to the pump and configured to remove moisture and bad breath in the respiratory gas; and a volatile organic compound (VOC) detection portion connected between the first pre-treatment portion and the pump to detect VOCs in the respiratory gas, wherein the first pre-treatment portion comprises: a first chamber; a moisture filter disposed in the first chamber to remove the moisture; and a bad breath filter disposed between the moisture filter and the VOC detection portion to remove the bad breath.

2 . The disease diagnosis device of claim 1 , wherein the bad breath filter comprises metal powder.

3 . The disease diagnosis device of claim 2 , wherein the metal powder comprises copper oxide or platinum.

4 . The disease diagnosis device of claim 1 , wherein the moisture filter comprises cotton.

5 . The disease diagnosis device of claim 1 , wherein the first pre-treatment portion further comprises a first heater disposed in the first chamber and surrounding the moisture filter and the bad breath filter.

6 . The disease diagnosis device of claim 1 , further comprising a second pre-treatment portion disposed between the first pre-treatment portion and the VOC detection portion to adjust moisture of the respiratory gas,
wherein the second pre-treatment portion comprises: a water bubbler configured to vaporize DI water; and a hygrometer disposed between the water bubbler and the VOC detection portion to detect moisture of the respiratory gas.

7 . The disease diagnosis device of claim 6 , wherein the water bubbler comprises:
a water bath configured to store the DI water; and a first nitrogen supply portion connected to the water bath and configured to generate vapor of the DI water by supplying a nitrogen gas into the DI water.

8 . The disease diagnosis device of claim 6 , further comprising a third pre-treatment portion disposed between the second pre-treatment portion of the VOC detection portion to adjust non-polar VOCs of the respiratory gas,
wherein the third pre-treatment portion comprises: a benzene bubbler configured to vaporize a benzene solution; and a non-polar VOC gas sensor disposed between the benzene bubbler and the VOC detection portion to detect the non-polar VOCs of the VOCs.

9 . The disease diagnosis device of claim 8 , wherein the benzene bubbler comprises:
a benzene bath configured to store the benzene solution; and a second nitrogen supply portion connected to the benzene bath and configured to generate the benzene gas by supplying a nitrogen gas into the benzene solution.

10 . The disease diagnosis device of claim 1 , wherein the VOC detection portion comprises a polar VOC sensor array.

11 . A disease diagnosis device comprising:
a pump configured to pump a respiratory gas; a first intake line connected to the pump; a first pre-treatment portion connected between the first intake line and the pump and configured to remove moisture and bad breath in the respiratory gas; a volatile organic compound (VOC) detection portion connected between the first pre-treatment portion and the pump to detect VOCs in the respiratory gas; a second intake line configured to connect the first pre-treatment portion to the VOC detection portion; and a first bypass line branched from the first intake line and connected to the second intake line to bypass the first pre-treatment portion.

12 . The disease diagnosis device of claim 11 , wherein the first intake line has a first intake valve,
the first bypass line has a first bypass valve that is opened and closed in an opposite manner to the first intake valve, and the disease diagnosis device further comprises a second intake valve disposed between the pump and the VOC detection portion.

13 . The disease diagnosis device of claim 11 , further comprising:
a second pre-treatment portion disposed between the first pre-treatment portion and the VOC detection portion; a third intake line disposed between the first pre-treatment portion and the second pre-treatment portion; and a second bypass line branched from the first bypass line and connected to the second intake line to bypass the second pre-treatment portion.

14 . The disease diagnosis device of claim 13 , further comprising:
a third pre-treatment portion disposed between the second pre-treatment portion and the VOC detection portion; a fourth intake line disposed between the second pre-treatment portion and the third pre-treatment portion; and a third bypass line branched from the second bypass line and connected to the third intake line to bypass the third pre-treatment portion.

15 . The disease diagnosis device of claim 14 , wherein the third intake line has a third intake valve,
the second bypass line has a second bypass valve that is opened and closed in an opposite manner to the third intake valve, the fourth intake line has a fourth intake valve, and the third bypass line has a third bypass valve that is opened and closed in an opposite manner to the fourth intake valve.

16 . A disease diagnosis method comprising:
pumping a respiratory gas; removing moisture in the respiratory gas by using a moisture filter; removing bad breath in the respiratory gas by using a bad breath filter; and determining lung cancer of a human body by detecting volatile organic compounds (VOCs) in the respiratory gas by using a sensor array.

17 . The disease diagnosis method of claim 16 , further comprising adjusting the moisture of the respiratory gas to reference moisture by vaporizing DI water.

18 . The disease diagnosis method of claim 17 , wherein the reference moisture is about 40% to about 60%.

19 . The disease diagnosis method of claim 16 , further comprising adjusting a concentration of non-polar VOCs in the respiratory gas to a reference concentration by vaporizing a benzene solution.

20 . The disease diagnosis method of claim 19 , wherein the reference concentration is about 0.1 ppm to about 0.5 ppm.

Assignees

• Electronics & Telecommunications Res Inst

Inventors

• Lee Dae-Sik
• Kwack Myungjoon
• Park Hyung Ju
• Lee Hyung-Kun
• Kim Doyeob
• Lee Jae Eun

Classifications

• A61B5/082 Primary

  Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath (A61B5/083, A61B5/091 take precedence) · CPC title

• A61B5/097

  Devices for facilitating collection of breath or for directing breath into or through measuring devices · CPC title

• B01D2257/90

  Odorous compounds not provided for in groups B01D2257/00 - B01D2257/708 · CPC title

• B01D2257/80

  Water · CPC title

• B01D2253/1122

  Metals · CPC title