Information processing device and program

Patent metadata

Field	Value
Publication number	US-2022276170-A1
Application number	US-202017623673-A
Country	US
Kind code	A1
Filing date	May 26, 2020
Priority date	Jul 9, 2019
Publication date	Sep 1, 2022
Grant date	—

Abstract

A specimen is analyzed with high accuracy. An information processing device includes an extraction unit ( 20 E) that extracts fluorescence correction information from a bright visual field image of a specimen, and a generation unit ( 20 F) that generates a fluorescence correction image based on fluorescence information of the specimen and the fluorescence correction information.

First claim

1 . An information processing device comprising:
an extraction unit that extracts fluorescence correction information from a bright visual field image of a specimen; and a generation unit that generates a fluorescence correction image based on fluorescence information of the specimen and the fluorescence correction information.

2 . The information processing device according to claim 1 , further comprising:
a fluorescence image acquisition unit that acquires a fluorescence image including the fluorescence information of the specimen; and a bright visual field image acquisition unit that acquires the bright visual field image.

3 . The information processing device according to claim 1 , wherein the fluorescence correction information is selected from color information, morphological information, or staining information of the bright visual field image.

4 . The information processing device according to claim 1 , further comprising:
an identification unit that identifies a correction target region of the bright visual field image based on the fluorescence correction information, wherein the generation unit generates the fluorescence correction image obtained by removing a region corresponding to the correction target region.

5 . The information processing device according to claim 1 , further comprising:
an identification unit that identifies a correction target region of the bright visual field image based on the fluorescence correction information, wherein the generation unit generates the fluorescence correction image based on peripheral information of the correction target region.

6 . The information processing device according to claim 4 , wherein
the generation unit generates the fluorescence correction image obtained by removing a region corresponding to the correction target region corrected based on a weight value according to a standard spectrum derived from a specimen.

7 . The information processing device according to claim 4 , wherein
the correction target region is an autofluorescence region or a light absorption region included in the bright visual field image.

8 . The information processing device according to claim 1 , further comprising:
a learning unit that learns a correspondence between the fluorescence information and the fluorescence correction information, wherein the generation unit generates the fluorescence correction image based on a learning result by the learning unit.

9 . The information processing device according to claim 2 , further comprising:
a display unit that displays at least one or more of the bright visual field image, a fluorescence image including the fluorescence information of the specimen, the fluorescence correction image, and a superimposed image obtained by superimposing the bright visual field image, and the fluorescence image or the fluorescence correction image.

10 . The information processing device according to claim 9 , wherein
the display unit is caused to display annotation information based on information about a correction target region of the bright visual field image.

11 . The information processing device according to claim 9 , wherein
the display unit is caused to display, in a bright visual field image, a correction target region of the bright visual field image and fluorescence signal information in the correction target region.

12 . The information processing device according to claim 1 , wherein the specimen includes an identical tissue section or continuous tissue sections.

13 . The information processing device according to claim 9 , wherein
the display unit changes one of the bright visual field image, the fluorescence image, the fluorescence correction image, and the superimposed image that are being displayed when a screen switching signal is received to any other one.

14 . The information processing device according to claim 1 , wherein
the information processing device further comprises a storage control unit that stores, for each of the specimens, a combined image defining, for each of pixels, a fluorescence intensity value of a fluorescence image including a color value of the bright visual field image and the fluorescence information of the specimens.

15 . The information processing device according to claim 1 , further comprising:
a learning unit that learns a correspondence between the fluorescence information of the specimen and the bright visual field image, wherein the generation unit generates a bright visual field correction image based on a learning result by the learning unit.

16 . A program causing a computer to execute the Steps of:
extracting fluorescence correction information from a bright visual field image of a specimen; and generating a fluorescence correction image based on fluorescence information of the specimen and the fluorescence correction information.

Assignees

• Sony Group Corp

Inventors

• Nakamura Tomohiko
• Nakagawa Kazuhiro
• Tatsuta Hirokazu

Classifications

• G06T2207/30024

  Cell structures in vitro; Tissue sections in vitro · CPC title

• G06T2207/10064

  Fluorescence image · CPC title

• G06T2207/10056

  Microscopic image · CPC title

• G01N21/6458 Primary

  Fluorescence microscopy (fluorescence microscopes per se G02B21/0076 and G02B21/16) · CPC title

• G01N2201/121

  Correction signals · CPC title