A bioprocess system

Patent metadata

Field	Value
Publication number	US-2022275317-A1
Application number	US-202017763135-A
Country	US
Kind code	A1
Filing date	Sep 30, 2020
Priority date	Oct 1, 2019
Publication date	Sep 1, 2022
Grant date	—

Abstract

Disclosed is a bioprocess system (1) comprising a flow path (3; 3a, 3) comprising: a plurality of inlets (7); at least one bio-processing device inlet connection (9a) and at least one bioprocessing device outlet connection (9b); a plurality of outlets (11); and flow path parts (5a′, 5b′, 5c′, 5d′, 5e′) of at least some active components (5a, 5b, 5c, 5d, 5e) comprised in the bioprocess system; and active parts (5a″, 5b″, 5c″, 5d″, 5e″) of said active components (5a, 5b, 5c, 5d, 5e). The flow path (3; 3a, 3b) of the bioprocess system is positioned centrally within the bioprocess system (1) and in a vertical orientation, whereby the active parts (5a″, 5b″, 5c″, 5d″, 5e″) are positioned around the flow path (3; 3a, 3b) being accessible from outside the bioprocess system (1) and each in connection with a corresponding flow path part (5a′, 5b′, 5c′, 5d′, 5e′) of an active component (5a, 5b, 5c, 5d, 5e).

First claim

1 . A bioprocess system comprising:
a flow path comprising:
a plurality of inlets;
at least one bioprocessing device inlet connection and at least one bioprocessing device outlet connection;
a plurality of outlets; and
flow path parts of at least some active components comprised in the bioprocess system: and
active parts of said active components,
wherein the flow path of the bioprocess system is positioned substantially centrally within the bioprocess system and in a substantially vertical orientation, whereby the active parts are positioned around the flow path being accessible from outside the bioprocess system and each in connection with a corresponding flow path part of an active component.

2 . The bioprocess system according to claim 1 , wherein the flow path is 3D printed in a number of sections or in one section.

3 . The bioprocess system according to claim 1 , wherein the flow path is at least to some degree self-supporting.

4 . The bioprocess system according to claim 1 , wherein the flow path is 3D printed with a thickness which is adapted such that the flow path is at least to some degree self-supporting, which thickness may vary for different parts of the flow path and/or wherein the flow path is 3D printed together with additional external support structures.

5 . The bioprocess system according claim 1 , wherein said active components comprise a number of valves and possibly also one or more pumps and one or more sensing components.

6 . The bioprocess system according to claim 1 , wherein said flow path is 3D printed from a corrosion resistant metal.

7 . The bioprocess system according to claim 1 , wherein the bioprocess system further comprises a support structure which comprises a central spine provided inside the flow path or a frame which is partly surrounding the flow path and which comprises user interface and tube connections.

8 . The bioprocess system according to claim 1 , having a footprint ranging from about 17 cm×17 cm to about 1.3 m×1.3 m for bioprocess systems having a capacity from 5 L to 1.000 L; a footprint ranging from about 14 cm×14 cm to about 1.1 m×1.1 m for bioprocess systems having a capacity from 5 L to 1.000 L; or a footprint ranging from about 11 cm×11 cm to about 85 cm×85 cm for bioprocess systems having a capacity from 5 L to 1.000 L.

9 . The bioprocess system according to claim 1 , having a footprint ranging from about 0.03 m 2 to about 1.7 m 2 for bioprocess systems having a capacity from 5 L to 1.000 L, a footprint ranging from about 0.02 m 2 to about 1.2 m 2 for bioprocess systems having a capacity from 5 L to 1.000 L. or a footprint ranging from about 0.01 m 2 to about 0.8 m 2 for bioprocess systems having a capacity from 5 L to 1,000 L.

10 . The bioprocess system according to claim 1 , wherein the flow path is at least partially 3D printed and provides a parts replacement ratio of >2:1, >3:1, >5:1 or >10:1.

Assignees

• Cytiva Sweden Ab

Inventors

• Marteleur Klas
• Marcstrom Andreas
• Olsson Mats
• Gebauer Klaus

Classifications

• C12M41/48

  Automatic or computerized control (automatic analysis G01N35/00) · CPC title

• C12M23/06 Primary

  Tubular (C12M23/08, C12M23/16 take precedence) · CPC title

• C12M29/00 Primary

  Means for introduction, extraction or recirculation of materials, e.g. pumps (pumps per se F04B) · CPC title

• B33Y80/00

  Products made by additive manufacturing · CPC title

• C12M23/40

  Manifolds; Distribution pieces (fluid transfer means B01L3/563) · CPC title