Single-pass filtration systems and processes
US-2015360180-A1 · Dec 17, 2015 · US
Tangential flow depth filtration systems and methods of filtration using same
US2022228098A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2022228098-A1 |
| Application number | US-202217713289-A |
| Country | US |
| Kind code | A1 |
| Filing date | Apr 5, 2022 |
| Priority date | Mar 8, 2018 |
| Publication date | Jul 21, 2022 |
| Grant date | — |
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Abstract
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The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
First claim
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What is claimed is: 1 . A method of filtering a fluid, comprising: performing alternating tangential flow (ATF) of a fluid through a tangential flow depth filter (TFDF) at a feed flow rate, the TFDF comprising a thick-walled hollow fiber, and controlling the feed flow rate of the fluid so that the flowing fluid undergoes turbulent flow. 2 . The method of claim 1 , wherein a Reynolds number of the flowing fluid is greater than about 2263. 3 . The method of claim 1 , wherein the hollow fiber comprises a density between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber. 4 . The method of claim 1 , wherein flowing the fluid comprises a flux of at least about 400 LMH. 5 . The method of claim 1 , further comprising: culturing the fluid within a lumen of the hollow fiber; and clarifying the fluid within the lumen. 6 . The method of claim 1 , wherein the hollow fiber comprises a porous wall formed by assembling at least one of a plurality of filaments and a plurality of particles into a tubular shape. 7 . The method of claim 6 , wherein a density of the hollow fiber is between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber. 8 . The method of claim 6 , wherein the porous wall further comprises at least one of a plurality of particles and a plurality of filaments. 9 . The method of claim 1 , wherein performing alternating tangential flow (ATF) of a fluid comprises pumping the fluid via an ATF pump. 10 . The method of claim 1 , wherein the fluid is flowed in a pulsatile manner. 11 . A method of filtering a fluid, comprising: performing alternating tangential flow (ATF) of a fluid through a tangential flow depth filter (TFDF) in a pulsatile manner, the TFDF comprising a thick-walled hollow fiber with a porous wall, and controlling a feed flow rate of the fluid so that the flowing fluid undergoes turbulent flow. 12 . The method of claim 11 , wherein a Reynolds number of the flowing fluid is greater than about 2263. 12 . The method of claim 11 , wherein the hollow fiber comprises a density between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber. 13 . The method of claim 11 , wherein performing alternating tangential flow (ATF) of a fluid comprises pumping the fluid via an ATF pump. 14 . The method of claim 11 , wherein the pulsatile manner comprises at least about 200 cycles per minute. 15 . The method of claim 11 , wherein the pulsatile manner comprises at least about 2000 cycles per minute. 16 . The method of claim 11 , wherein the hollow fiber comprises a porous wall formed by assembling at least one of a plurality of filaments and a plurality of particles into a tubular shape. 17 . The method of claim 11 , further comprising: culturing the fluid within a lumen of the hollow fiber; and clarifying the fluid within the lumen. 18 . A method of filtering a fluid, comprising: performing alternating tangential flow (ATF) of a fluid through a tangential flow depth filter (TFDF) using an ATF pump, wherein the TFDF comprises a thick-walled hollow fiber comprising at least one of a plurality of filaments and a plurality of particles formed into a tubular shape, and controlling a feed flow rate of the fluid such that the flowing fluid undergoes turbulent flow. 19 . The method of claim 18 , wherein a Reynolds number of the flowing fluid is greater than about 2263. 20 . The method of claim 18 , wherein the fluid is flowed in a pulsatile manner.
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- What does patent US2022228098A1 cover?
- The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
- Who is the assignee on this patent?
- Repligen Corp
- What technology area does this patent fall under?
- Primary CPC classification B01D61/18. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Thu Jul 21 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).