Nitrogenous gas sustained releasing agent and nitrogenous gas sustained releaser composed of the same as well as nitrogenous gas sustained releasing method, respiratory equipment, package, and sustained releasing apparatus using the sustained releaser

Patent metadata

Field	Value
Publication number	US-2022211748-A1
Application number	US-202017604387-A
Country	US
Kind code	A1
Filing date	Apr 1, 2020
Priority date	Apr 19, 2019
Publication date	Jul 7, 2022
Grant date	—

Abstract

The invention provides a nitrogenous gas sustained releasing agent that is capable of sustainably releasing off nitrogenous gases in the air at normal temperature and safe to handle and a nitrogenous gas sustained releaser composed of the same as well as a nitrogenous gas sustained releasing method, respiratory equipment, a package and a nitrogenous gas sustained releasing apparatus using said sustained releaser. The nitrogenous gas sustained releasing agent contains a layered double hydroxide having nitrite ions (NO 2 − ) and/or nitrate ions (NO 3 − ) included between layers. The nitrogenous gas sustained releaser composed of the sustained releasing agent is exposed to a gas containing carbon dioxide and water vapor to induce any one or more processes of sustained release of nitrous acid, self-decomposition of nitrous acid, oxidization/reduction of nitrous acid, and reduction of nitrite ions/nitrate ions thereby sustainably releasing off nitrogenous gases.

First claim

1 . A sustained releasing agent of sustainably releasing off nitrogenous gases, which contains a layered double hydroxide having a nitrite ion (NO 2 − ) and/or a nitrate ion (NO 3 − ) included between layers.

2 . The sustained releasing agent according to claim 1 , wherein said nitrogenous gases are at least one gas selected from the group consisting of nitrogen monoxide gas (NO), nitrous acid vapor (HNO 2 ) and nitrogen dioxide gas (NO 2 ).

3 . The sustained releasing agent according to claim 1 , wherein said layered double hydroxide is represented by the following general formula (1):
Q x R(OH) 2(x+1) {(NO 2 − ) d (NO 3 − ) g Z j }·n H 2 O  (1)
where Q is a divalent metal ion, R is a trivalent metal ion, Z is an anion other than NO 2 − and NO 3 − , each of x, d, g and j is a number that satisfies 1.8≤x≤4.2, 0.01≤d+g≤2.0 and 0≤j≤1.0, and n is a number that changes depending on an environmental humidity.

4 . The sustained releasing agent according to claim 3 , wherein, in said general formula (1), said Q is at least one selected from the group consisting of Mg 2+ , Mn 2+ , Fe 2+ , Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ and Ca 2+ , and said R is at least one selected from the group consisting of Al 3 , Ga 3+ , Cr 3+ , Mn 3+ , Fe 3+ , Co 3+ and Ni 3+ .

5 . (canceled)

6 . A nitrogenous gas sustained releaser, which is composed of said sustained releasing agent according to claim 1 .

7 . The sustained releaser according to claim 6 , which further contains a solid reducing agent or a solid oxidizing agent.

8 . The sustained releaser according to claim 7 , wherein said sustained releasing agent is mixed with said solid reducing agent or said solid oxidizing agent.

9 . (canceled)

10 . (canceled)

11 . (canceled)

12 . A nitrogenous gas sustained releasing method using a nitrogenous gas sustained releaser,
wherein said sustained releaser is composed of a nitrogenous gas sustained releasing agent containing a layered double hydroxide having a nitrite ion (NO 2 − ) and/or a nitrate ion (NO 3 − ) included between layers, and being capable of sustainably releasing off nitrogenous gases, and comprises a step of bringing a gas containing carbon dioxide and/or water vapor in contact with the nitrogenous gas sustained releaser.

13 . (canceled)

14 . The nitrogenous gas sustained releasing method according to claim 12 ,
wherein the layered double hydroxide that composes the nitrogenous gas sustained releaser includes at least a nitrite ion (NO 2 − ) between layers, and further includes a step of bringing nitrous acid vapor obtained in the gas contact step in contact with a solid reducing agent or solid oxidizing agent.

15 . The nitrogenous gas sustained releasing method according to claim 12 , wherein a mixture of said sustained releasing agent with a solid reducing agent and/or a solid oxidizing agent is used as said sustained releaser, and the method further includes a step of bringing a gas having a relative humidity of 40% or more in contact with said releaser.

16 . The nitrogenous gas sustained releasing method according to claim 12 , which further include a step of removing impurities in the gas sustainably released out of said releaser using an adsorbent.

17 . The nitrogenous gas sustained releasing method according to claim 16 , wherein said adsorbent contains magnesium hydroxide or calcium hydroxide.

18 . (canceled)

19 . A package comprising:
the sustained releaser according to claim 6 ; and a wrapping material adapted to seal up and contain said releaser.

20 . The package according to claim 19 , wherein an atmosphere selected from the group consisting of a voidless atmosphere, a vacuum atmosphere, an inert gas atmosphere and a dry atmosphere fills in said wrapping material.

21 . An apparatus for sustainably releasing off nitrogenous gases comprising:
an atmospheric gas feeding portion adapted to feed an atmospheric gas; and a nitrogenous gas sustained releasing portion adapted to sustainably release off nitrogenous gases by the atmospheric gas fed from said atmospheric gas feeding portion, wherein said nitrogenous gas sustained releasing portion comprises a nitrogenous gas releaser composed of a sustained releasing agent containing a layered double hydroxide having a nitrite ion (NO 2 − ) and/or a nitrate ion (NO 3 − ) included between layers, and being capable of sustainably releasing off the nitrogenous gases.

22 . The apparatus according to claim 21 , which further comprise an impurity removal portion adapted to remove impurities in said nitrogenous gases sustainably released out of said nitrogenous gas releasing portion.

23 . The apparatus according to claim 22 , wherein said sustained releaser further contains a solid reducing agent or a solid oxidizing agent, which is in a mixture with said sustained releasing agent, and said atmospheric gas feeding portion is adapted to feed a gas having a relative humidity of 40% or more.

24 . (canceled)

25 . The apparatus according to claim 21 , wherein said sustained releaser further includes a solid reducing agent or a solid oxidizing agent in the rear stage of said sustained releasing agent.

26 . The apparatus according to claim 25 , wherein said atmospheric gas feeding portion is adapted to feed a gas containing at least water vapor or carbon dioxide.

27 . The apparatus according to claim 21 , wherein said nitrogenous gas is nitrogen monoxide.

Assignees

• Nat Inst Materials Science

Inventors

• Ishihara Shinsuke
• Iyi Nobuo

Classifications

• A61M16/12

  by mixing different gases · CPC title

• A61K9/0004

  Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas · CPC title

• A61M2202/0275

  Nitric oxide [NO] · CPC title

• B01J20/041

  Oxides or hydroxides · CPC title

• A61K33/00 Primary

  Medicinal preparations containing inorganic active ingredients · CPC title