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Magnetic responsive particle and immunoassay method using same, reagent for immunoassay
US2022187287A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2022187287-A1 |
| Application number | US-202017598015-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 25, 2020 |
| Priority date | Mar 26, 2019 |
| Publication date | Jun 16, 2022 |
| Grant date | — |
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- Title
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Abstract
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Disclosed is a sensitized magnetic responsive particle including: a magnetic responsive particle having a core particle and at least one magnetic layer that is disposed on the core particle and includes microparticles of a magnetic metal and/or an oxide thereof; and a substance that is supported on the magnetic responsive Particle and interacts specifically with an analyte, wherein the coefficient of variation in the weight-average particle size of the magnetic responsive particles is 15% or less. The magnetic responsive particle provided has excellent magnetic separability.
First claim
Opening claim text (preview).
1 . A sensitized magnetic responsive particle comprising: a magnetic responsive particle having a core particle and at least one magnetic layer disposed on the core particle, the magnetic layer comprising microparticles of a magnetic metal and/or an oxide thereof; and a substance that specifically interacts with an analyte, the substance being supported on the magnetic responsive particle, wherein a coefficient of variation in a weight-average particle size of the magnetic responsive particles is 15% or less. 2 . The sensitized magnetic responsive particle according to claim 1 , wherein the coefficient of variation in a volume-average particle size of the magnetic responsive particles is 20% or less. 3 . A sensitized magnetic responsive particle comprising: a magnetic responsive particle having a core particle and at least one magnetic layer disposed on the core particle, the magnetic layer comprising microparticles of a magnetic metal and/or an oxide thereof; and a substance that specifically interacts with an analyte, the substance being supported on the magnetic responsive particle, wherein a coefficient of variation in a weight-average particle size of the sensitized magnetic responsive particles is 15% or less. 4 . The sensitized magnetic responsive particle according to claim 3 , wherein the coefficient of variation in a volume-average particle size of the sensitized magnetic responsive particles is 20% or less. 5 . The sensitized magnetic responsive particle according to claim 1 , further comprising a nonmagnetic layer comprising a nonmagnetic metal oxide and/or an organic metal compound between the magnetic layer and the substance interacting specifically with the analyte. 6 . The sensitized magnetic responsive particle according to claim 1 , wherein the substance interacting specifically with the analyte is chemically bonded onto the magnetic layer through a one-step or multi-step reaction. 7 . The sensitized magnetic responsive particle according to claim 1 , wherein the substance interacting specifically with the analyte is bonded onto the nonmagnetic layer via one or multiple chemical bonds. 8 . A heterogeneous immunoassay method using the sensitized magnetic responsive particle according to claim 1 . 9 . An immunoassay reagent comprising the sensitized magnetic responsive particle according to claim 1 . 10 . The sensitized magnetic responsive particle according to claim 2 , further comprising a nonmagnetic layer comprising a nonmagnetic metal oxide and/or an organic metal compound between the magnetic layer and the substance interacting specifically with the analyte. 11 . The sensitized magnetic responsive particle according to claim 3 , further comprising a nonmagnetic layer comprising a nonmagnetic metal oxide and/or an organic metal compound between the magnetic layer and the substance interacting specifically with the analyte. 12 . The sensitized magnetic responsive particle according to claim 4 , further comprising a nonmagnetic layer comprising a nonmagnetic metal oxide and/or an organic metal compound between the magnetic layer and the substance interacting specifically with the analyte. 13 . The sensitized magnetic responsive particle according to claim 2 , wherein the substance interacting specifically with the analyte is chemically bonded onto the magnetic layer through a one-step or multi-step reaction. 14 . The sensitized magnetic responsive particle according to claim 3 , wherein the substance interacting specifically with the analyte is chemically bonded onto the magnetic layer through a one-step or multi-step reaction. 15 . The sensitized magnetic responsive particle according to claim 4 , wherein the substance interacting specifically with the analyte is chemically bonded onto the magnetic layer through a one-step or multi-step reaction. 16 . The sensitized magnetic responsive particle according to claim 5 , wherein the substance interacting specifically with the analyte is chemically bonded onto the magnetic layer through a one-step or multi-step reaction. 17 . The sensitized magnetic responsive particle according to claim 2 , wherein the substance interacting specifically with the analyte is bonded onto the nonmagnetic layer via one or multiple chemical bonds. 18 . The sensitized magnetic responsive particle according to claim 3 , wherein the substance interacting specifically with the analyte is bonded onto the nonmagnetic layer via one or multiple chemical bonds. 19 . The sensitized magnetic responsive particle according to claim 4 , wherein the substance interacting specifically with the analyte is bonded onto the nonmagnetic layer via one or multiple chemical bonds. 20 . The sensitized magnetic responsive particle according to claim 5 , wherein the substance interacting specifically with the analyte is bonded onto the nonmagnetic layer via one or multiple chemical bonds.
Assignees
Inventors
Classifications
- G01N33/54306Primary
Solid-phase reaction mechanisms · CPC title
- G01N33/553Primary
Metal or metal coated · CPC title
- G01N33/54326Primary
Magnetic particles · CPC title
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Frequently asked questions
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- What does patent US2022187287A1 cover?
- Disclosed is a sensitized magnetic responsive particle including: a magnetic responsive particle having a core particle and at least one magnetic layer that is disposed on the core particle and includes microparticles of a magnetic metal and/or an oxide thereof; and a substance that is supported on the magnetic responsive Particle and interacts specifically with an analyte, wherein the coeffici…
- Who is the assignee on this patent?
- Sekisui Medical Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification G01N33/54306. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Thu Jun 16 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).