Fasting mimicking ketogenic diet (fmd) to promote skeletal muscle regeneration and strength

Patent metadata

Field	Value
Publication number	US-2022175006-A1
Application number	US-202117541558-A
Country	US
Kind code	A1
Filing date	Dec 3, 2021
Priority date	Dec 3, 2020
Publication date	Jun 9, 2022
Grant date	—

Abstract

A dietary composition and method for treating a subject that is in need of muscle regeneration and/or maintenance and improvement of muscle mass and strength. The method includes a step of administering an FMD to a subject that is in need of muscle regeneration and/or maintenance and improvement of muscle mass and strength for a first time period.

First claim

What is claimed is:

1 . A method comprising:
administering a fasting-mimicking diet to a subject that is in need of muscle regeneration and/or maintenance and/or improvement of muscle mass and strength for a first time period.

2 . The method of claim 1 , wherein the fasting-mimicking diet includes lyophilized vegetable soups, bars, olives, crackers, herbal teas, supplements of vitamins and minerals.

3 . The method of claim 1 , wherein the fasting-mimicking diet is administered for 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 days.

4 . The method of claim 1 , wherein the fasting-mimicking diet is formulated to provide 800 to 1250 kcal on day 1 and 500 to 950 kcal on days 2, 3, 4, 5, or any additional days.

5 . The method of claim 1 , wherein the fasting-mimicking diet is formulated to provide 2.4 to 7 kcal per day for each day of the fasting-mimicking diet, less than or equal to 30 g of sugar for each day of the fasting-mimicking diet, less than 30 g of proteins for each day of the fasting-mimicking diet, 15-30 grams of monounsaturated fats for each day of the fasting-mimicking diet, 2-10 g of polyunsaturated fats for each day of the fasting-mimicking diet, and less than 12 g of saturated fats for each day of the fasting-mimicking diet.

6 . The method of claim 1 , wherein the fasting-mimicking diet for day 1, total calorie consumption is 3.5-5 kcal per pound of the subject.

7 . The method of claim 6 , wherein for day 1, the fasting-mimicking diet includes less than 25 g of sugar, less than 23 g of proteins, 16-25 grams of monounsaturated fats, 4.8-8 g of polyunsaturated fats, and 1-10 g of saturated fats.

8 . The method of claim 7 , wherein for days 2-5 or any additional days, total calorie consumption is 2.4-4 kcal per pound of the subject.

9 . The method of claim 8 , wherein for days 2, 3, 4, 5, or any additional days, the fasting-mimicking diet includes contain less than 16 g of sugars, less than 15 g of protein, 8 to 12 g of monounsaturated fats, 2 to 4 g of polyunsaturated fats and 1 to 6 grams of saturated fats.

10 . The method of claim 1 , wherein the fasting-mimicking diet includes soups, nutrition bars, crackers, an optional drink with a glucose substitute, olives, vitamin and mineral supplements, algal oil, and optional teas.

11 . The method of claim 10 , wherein the fasting-mimicking diet includes nutrition bars and soups to be consumed for breakfast, lunch, and dinner.

12 . The method of claim 11 , wherein the fasting-mimicking diet includes an FMD soup formulated to provide less than about 1 gram of saturated fat per serving, less than about 5 grams of trans fat per serving, less than about 10 grams of protein per serving, less than about 40 grams of carbohydrates per serving.

13 . The method of claim 12 , wherein the FMD soup is formulated from any combination of components selected from the group consisting of black beans, butternut squash, quinoa , tomatoes, mushrooms, white beans, brown beans, spinach, green tea extract, rice flour, onions, brown rice powder, carrots, inulin, leeks, olive oil, cabbage, potatoes, olives, peas, pumpkin, maltodextrin, and celery, chicory root fiber, sea salt, yeast, basil, parsley, garlic, rosemary extract, coriander, oregano, potato starch, potato flakes, zucchini squash, turmeric.

14 . The method of claim 12 , wherein the FMD soup is formulated from a first component selected from the group consisting of black beans, butternut squash, quinoa , tomatoes, mushrooms, white beans, brown beans, spinach, and combinations thereof and a second component selected from the group consisting of green tea extract, rice flour, onions, brown rice powder, carrots, inulin, leeks, olive oil, cabbage, potatoes, olives, peas, pumpkin, maltodextrin, and celery, chicory root fiber, sea salt, yeast, basil, parsley, garlic, rosemary extract, coriander, oregano, potato starch, potato flakes, zucchini squash, turmeric, and combinations thereof.

15 . The method of claim 11 , wherein the fasting-mimicking diet includes a first FMD nutrition bar formulated to provide about bout 150 kcal to 350 kcal per serving, 10 to 35 grams of total fat per serving, less than about 8 grams of saturated fat per serving, less than about 5 grams of trans fat per serving, less than about 10 grams of protein per serving, and less than about 30 grams of carbohydrates per serving.

16 . The method of claim 15 , wherein the first FMD nutrition bar is formulated from a combination of macadamia nuts, honey, pecans, almonds, almond butter, coconut flour, sea salt, mixed tocopherols (vitamin E), citric acid, and/or ascorbic acid.

17 . The method of claim 11 , wherein the fasting-mimicking diet includes a second FMD nutrition bar formulated to provide about bout 70 kcal to 120 kcal per serving, 3 to 10 grams of total fat per serving, less than about 5 grams of saturated fat per serving, less than about 5 gram of trans fat per serving, less than about 6 grams of protein per serving, and less than about 20 grams of carbohydrates per serving.

18 . The method of claim 17 , wherein the second FMD nutrition bar is formulated from a combination of inulin, almond butter, brown rice crispy, cocoa powder, almonds, chocolate chips, rolled oats, brown rice syrup, flaxseed oil, rice dextrin, grape juice, and salt.

19 . The method of claim 1 , wherein the fasting-mimicking diet includes a drink that includes a glucose substitute.

20 . The method of claim 1 , wherein a refeeding diet is administered to the subject for a second time period.

21 . The method of claim 20 , wherein the fasting-mimicking diet and the refeeding diet are repeated for a plurality of cycles.

22 . A method for preparing a fasting-mimicking diet package for treating a subject that is in need of muscle regeneration and/or maintenance and/or improvement of muscle mass and strength, the fasting-mimicking diet package including breakfast, lunch, and dinner meal portions for administering a fasting-mimicking diet for each day of a first time period. the method comprising:
receiving subject information for the subject that includes a subject's weight; and forming meal portions for each day of a predetermined time period during which the fasting-mimicking diet is administered, the meal portions providing the subject with at most 50 percent of a subject's normal calorie consumption per day with protein and sugar rejection.

23 . The method of claim 22 , wherein the fasting-mimicking diet is formulated to provide 2.4 to 7 kcal per day for each day of the fasting-mimicking diet, less than or equal to 30 g of sugar for each day of the fasting-mimicking diet, less than 30 g of proteins for each day of the fasting-mimicking diet, 15-30 grams of monounsaturated fats for each day of the fasting-mimicking diet, 2-10 g of polyunsaturated fats for each day of the fasting-mimicking diet, and less than 12 g of saturated fats for each day of the fasting-mimicking diet.

24 . The method of claim 23 , wherein the ranges are scaled with by a factor of subjects weight in pounds divided by 180.

25 . The method of claim 23 , wherein the meal portions provide the subject with from 30 to 50 percent of the subject's normal calorie consumption per day.

26 . The method of claim 22 , wherein the fasting-mimicking diet is administered for 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 consecutive days.

27 . The method of claim 26 , wherein the fastin

Assignees

• Univ Southern California

Inventors

• Longo Valter D
• Crupi Annunziata Nancy

Classifications

• A23L33/155

  Vitamins A or D · CPC title

• A23L33/30 Primary

  Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence) · CPC title

• A23L33/16

  Inorganic salts, minerals or trace elements · CPC title

• A23L19/03

  consisting of whole pieces or fragments without mashing the original pieces · CPC title

• A23F3/163 Primary

  Liquid or semi-liquid tea extract preparations, e.g. gels or liquid extracts in solid capsules · CPC title