Occlusive implant compositions

Patent metadata

Field	Value
Publication number	US-2022168461-A1
Application number	US-202217651509-A
Country	US
Kind code	A1
Filing date	Feb 17, 2022
Priority date	Nov 12, 2015
Publication date	Jun 2, 2022
Grant date	—

Abstract

Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

First claim

What is claims is:

1 . A composition comprising:
one or more species with a diameter of 0.1 to 1 μm in solvent; wherein the one or more species are capable of forming an implantable network with pores with a diameter of less than or equal to 3 μm; wherein the one or more species and/or the implantable network are capable of being injected into a bodily lumen; and wherein the implantable network has a permanent lifespan in vivo.

2 . The composition of claim 1 , wherein one or more of the species comprises one or more of natural or synthetic monomers, polymers, copolymers or block copolymers, biocompatible monomers, polymers, copolymers or block copolymers, polystyrene, neoprene, polyetherether 10 ketone (PEEK), carbon reinforced PEEK, polyphenylene, polyetherketoneketone (PEKK), polyaryletherketone (PAEK), polyphenylsulphone, polysulphone, polyurethane, polyethylene, low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), high-density polyethylene (HDPE), polypropylene, polyetherketoneetherketoneketone (PEKEKK), nylon, fluoropolymers, polytetrafluoroethylene (PTFE or TEFLON®), TEFLON® TFE (tetrafluoroethylene), polyethylene terephthalate (PET or PETE), TEFLON® FEP (fluorinated ethylene propylene), TEFLON® PFA (perfluoroalkoxy alkane), and/or polymethylpentene (PMP) styrene maleic anhydride, styrene maleic acid (SMA), polyurethane, silicone, polymethyl methacrylate, polyacrylonitrile, poly (carbonate-urethane), poly (vinylacetate), nitrocellulose, cellulose acetate, urethane, urethane/carbonate, polylactic acid, polyacrylamide (PAAM), poly (N-isopropylacrylamine) (PNIPAM), poly (vinylmethylether), poly (ethylene oxide), poly (ethyl (hydroxyethyl) cellulose), poly(2-ethyl oxazoline), polylactide (PLA), polyglycolide (PGA), poly(lactide-co-glycolide) PLGA, poly(e-caprolactone), polydiaoxanone, polyanhydride, trimethylene carbonate, poly(β-hydroxybutyrate), poly(g-ethyl glutamate), poly(DTH-iminocarbonate), poly(bisphenol A iminocarbonate), poly(orthoester) (POE), polycyanoacrylate (PCA), polyphosphazene, polyethyleneoxide (PEO), polyethyleneglycol (PEG), polyacrylacid (PAA), polyacrylonitrile (PAN), polyvinylacrylate (PVA), polyvinylpyrrolidone (PVP), polyglycolic lactic acid (PGLA), poly(2-hydroxypropyl methacrylamide) (pHPMAm), poly(vinyl alcohol) (PVOH), PEG diacrylate (PEGDA), poly(hydroxyethyl methacrylate) (pHEMA), N-isopropylacrylamide (NIPA), poly(vinyl alcohol) poly(acrylic acid) (PVOH-PAA), collagen, silk, fibrin, gelatin, hyaluron, cellulose, chitin, dextran, casein, albumin, ovalbumin, heparin sulfate, starch, agar, heparin, alginate, fibronectin, fibrin, keratin, pectin, elastin, ethylene vinyl acetate, ethylene vinyl alcohol (EVOH), polyethylene oxide, PLA or PLLA (poly(L-lactide) or pol(L-lactic acid)), poly(D.L-lactic acid), poly(D,L-lactide), polydimethylsiloxane or dimethicone (PDMS), poly(isopropyl acrylate) (PIPA), polyethylene vinyl acetate (PEVA), PEG styrene, polytetraflurorethylene RFE, TEFLON® RFE, KRYTOX® RFE, fluorinated polyethylene (FLPE or NALGENE®, methyl palmitate, temperature responsive polymers, poly(N-isopropylacrylamide) (NIPA), polycarbonate, polyethersulfone, polycaprolactone, polymethyl methacrylate, polyisobutylene, nitrocellulose, medical grade silicone, cellulose acetate, cellulose acetate butyrate, polyacrylonitrile, poly(lactide-co-caprolactone (PLCL), and/or chitosan.

3 . The composition of claim 1 , wherein one or more of the species are capable of crosslinking.

4 . The composition of claim 1 , wherein one or more of the species are capable of crosslinking and forming an implantable network by way of a bio-orthogonal reaction.

5 . The composition of claim 1 , wherein the solvent comprises an aqueous solvent, organic solvent, or a combination of both aqueous and organic solvents.

6 . The composition of claim 1 , wherein the solvent comprises one or more of dimethyl sulfoxide (DMSO), sodium bicarbonate, potassium bicarbonate, chloroform, or alkaline solutions.

7 . The composition of claim 1 , wherein one or more of the species is a polymer with a weight average molecular weight (M w ) or number-average molecular weight (M n ) ranging from about 1,000 to 1,000,000 Daltons.

8 . The composition of claim 1 having a viscosity of 1-7 Pa*s.

9 . The composition of claim 1 having a pH in the range of 8 to 9.

10 . The composition of claim 1 having an alkaline pH.

11 . The composition of claim 1 having a pH in the range of neutral to acidic.

12 . The composition of claim 1 , wherein the composition has a storage modulus G′ ranging from 0.001 Pa to 10,000 Pa at a temperature ranging from 20-160° C.

13 . The composition of claim 1 , wherein the composition has a loss modulus G″ ranging from 0.1 Pa to 1,000 Pa at a temperature ranging from 20-160° C.

14 . The composition of claim 1 , wherein the composition has a mass percent swelling in the range of 40-120%.

15 . The composition of claim 1 , wherein one or more of the species comprises microbubbles.

Assignees

• Univ Virginia Patent Foundation

Inventors

• Herr John C
• Klibanov Alexander L
• Eisenfrats Kevin Simon

Classifications

• A61F6/22 Primary

  implantable in tubes {(occluding by internal devices A61B17/12022)} · CPC title

• A61P15/16

  Masculine contraceptives · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• A61L2300/626

  Liposomes, micelles, vesicles · CPC title