Chitosan-based nanocomposite as an antimicrobial agent and corrosion inhibitor

Patent metadata

Field	Value
Publication number	US-2022127436-A1
Application number	US-202017423380-A
Country	US
Kind code	A1
Filing date	Jan 18, 2020
Priority date	Jan 19, 2019
Publication date	Apr 28, 2022
Grant date	—

Abstract

Antimicrobial agents and corrosion inhibitors are widely used as biocides in the oil and gas industry to disinfect the water and inhibit excessive biofilm formation and microbial induced corrosion (MIC) caused mainly by sulfate reducing bacteria (SRB). However, traditional biocides may induce bacterial resistance and/or be detrimental to environment by forming harmful disinfection byproducts. A chitosan-based nanocomposite is successfully implemented as a novel green biocide for treatment of water, the inhibition of sulfate reducing bacteria (SRB) and reduction of biocorrosion on SS400 carbon steel.

First claim

1 - 26 . (canceled)

27 . A formulation comprising:
chitosan; and at least one component selected from the group consisting of lignin, lignosulfonate (Ln), lignosulfonic acid (LS), milled wood lignin, milled wood enzyme lignin, lignocellulose, brauns' native lignin, chemical lignin, klason lignin, organsolv lignin, pyrolytic lignin, steam explosion lignin, lignophenol, kraft lignin and sodium-lignosulfonate, lignin nanoparticles, and combinations thereof, wherein the chitosan is chemically and/or physically crosslinked with the at least one component selected from the group consisting of lignin, lignosulfonate (Ln), lignosulfonic acid (LS), milled wood lignin, milled wood enzyme lignin, lignocellulose, brauns' native lignin, chemical lignin, klason lignin, organsolv lignin, pyrolytic lignin, steam explosion lignin, lignophenol, kraft lignin and sodium-lignosulfonate, lignin nanoparticles, and combinations thereof.

28 . The formulation according to claim 1 , wherein the crosslinking agent is selected from the group consisting of formaldehyde, phthalaldehyde, glyoxal, succindialdehyde, glutaraldehyde, acetaldehyde, propionaldehyde, butyraldehyde, benzaldehyde (phenylmethanal), cinnamaldehyde, tolualdehyde, furfural, malondialdehyde, dodecyl aldehyde, lauric aldehyde, other types of aldehyde such as dialdehyde, and combinations thereof.

29 . The formulation according to claim 1 , wherein the crosslinking agent is formaldehyde.

30 . The formulation according to claim 1 , wherein the chitosan has molecular weight ranging between 50000 Da and 375000 Da.

31 . The formulation according to claim 1 , wherein the chitosan has a degree of acetylation between 0 and 99/a.

32 . A chitosan-based nanocomposite comprising: chitosan and at least one component selected from the group consisting of chemically and/or physically crosslinked chitosan-lignosulfonate nanoparticles, chemically and/or physically crosslinked chitosan-lignosulfonic acid nanocomposites, chemically and/or physically crosslinked chitosan-milled wood lignin nanoparticles, chemically and/or physically crosslinked chitosan-milled wood enzyme lignin nanoparticles, chemically and/or physically crosslinked chitosan-lignocellulose nanoparticles, chemically and/or physically crosslinked chitosan-brauns' native lignin nanoparticles, chemically and/or physically crosslinked chitosan-chemical lignin nanoparticles, chemically and/or physically crosslinked chitosan-klason lignin nanoparticles, chemically and/or physically crosslinked chitosan-organsolv lignin nanoparticles, chemically and/or physically crosslinked chitosan-pyrolytic lignin nanoparticles, chemically and/or physically crosslinked chitosan-steam explosion lignin nanoparticles, chemically and/or physically crosslinked chitosan-lignophenol nanoparticles, chemically and/or physically crosslinked chitosan-kraft lignin nanoparticles, and combinations thereof.

33 . The chitosan-based nanocomposite of claim 6 , wherein the at least one component is selected from the group consisting of chemically crosslinked chitosan-lignosulfonate nanoparticles, chemically crosslinked chitosan-lignosulfonic acid nanocomposites, chemically crosslinked chitosan-milled wood lignin nanoparticles, chemically crosslinked chitosan-milled wood enzyme lignin nanoparticles, chemically crosslinked chitosan-lignocellulose nanoparticles, chemically crosslinked chitosan-brauns' native lignin nanoparticles, chemically crosslinked chitosan-chemical lignin nanoparticles, chemically crosslinked chitosan-klason lignin nanoparticles, chemically crosslinked chitosan-organsolv lignin nanoparticles, chemically crosslinked chitosan-pyrolytic lignin nanoparticles, chemically crosslinked chitosan-steam explosion lignin nanoparticles, chemically crosslinked chitosan-lignophenol nanoparticles, chemically crosslinked chitosan-kraft lignin nanoparticles, and combinations thereof.

34 . The chitosan-based nanocomposite of claim 7 , wherein the chemically crosslinked chitosan-lignosulfonate nanoparticles, the chemically crosslinked chitosan-lignosulfonic acid nanocomposites, the chemically crosslinked chitosan-milled wood lignin nanoparticles, the chemically crosslinked chitosan-milled wood enzyme lignin nanoparticles, the chemically crosslinked chitosan-lignocellulose nanoparticles, the chemically crosslinked chitosan-brauns' native lignin nanoparticles, the chemically crosslinked chitosan-chemical lignin nanoparticles, the chemically crosslinked chitosan-klason lignin nanoparticles, the chemically crosslinked chitosan-organsolv lignin nanoparticles, the chemically crosslinked chitosan-pyrolytic lignin nanoparticles, the chemically crosslinked chitosan-steam explosion lignin nanoparticles, the chemically crosslinked chitosan-lignophenol nanoparticles, and the chemically crosslinked chitosan-kraft lignin nanoparticles comprise a crosslinking agent.

35 . The chitosan-based nanocomposite of claim 8 , wherein the crosslinking agent is selected from the group consisting of formaldehyde, phthalaldehyde, glyoxal, succindialdehyde, glutaraldehyde, acetaldehyde, propionaldehyde, butyraldehyde, benzaldehyde (phenylmethanal), cinnamaldehyde, tolualdehyde, furfural, malondialdehyde, dodecyl aldehyde, lauric aldehyde, other types of aldehyde such as dialdehyde, and combinations thereof.

36 . The chitosan-based nanocomposite of claim 8 , wherein the crosslinking agent is formaldehyde.

37 . The chitosan-based nanocomposite of claim 6 , wherein the chitosan has molecular weight ranging between 50000 Da and 375000 Da.

38 . The chitosan-based nanocomposite of claim 6 , wherein the chitosan has a degree of acetylation between 0 and 99%.

39 . A method of preparing a chitosan-based nanocomposite comprising steps of:
(1) preparing a chitosan (Ch) solution and a lignin-based compound solution; (2) mixed the chitosan (Ch) solution and the lignin-based compound solution of step (1) together under constant stirring for a first duration of time to form a mixed solution; (3) preparing a cross-linking agent solution by adding a metal sulfate, an aldehyde, and an acid in water under constant stirring for a second duration of time; (4) adding a chemically sufficient amount of the cross-linking agent solution gradually with the help of syringe into the mixed solution and stirring the resulting solution for a third duration of time; and (5) washing the resulting solution in step (4) and centrifuging the resulting solution to obtain the chitosan-based nanocomposite.

40 . The method of claim 13 , wherein the lignin-based compound solution is a lignosulfate solution.

41 . The method of claim 13 , wherein the metal sulfate is sodium sulfate.

42 . The method of claim 13 , wherein the aldehyde is formaldehyde.

43 . The method of claim 13 , wherein the acid is sulfuric acid.

44 . The method of claim 13 , wherein the resulting solution in step (5) is centrifuged at 10,000 rpm.

45 . A method for treating a condition selected from the group consisting of antimicrobial coatings, water disinfection, adsorbent, water pollutant removal, membranes, wastewater treatment, seawater disinfection, food packaging, removal of dyes, Scaffold for tissue engineering, drug delivery, wound dressing, anti-fungal, acid removal, sulfate-reducing bacteria, acid-producing bacteria, and iron-reducing bacteria, the method comprising administering a chemically sufficient amount of the formulation of claim 1 .

46 . A method for treating a condition selected from the group consisting of Antimicrobial coat

Assignees

• Qatar Found Education Science & Community Dev

Inventors

• Rasheed Abdul P
• Rasool Kashif
• Pandey Ravi P
• Mahmoud Khaled A

Classifications

• C08L5/08 Primary

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title

• C08L97/005

  Lignin · CPC title

• A01N59/16

  Heavy metals; Compounds thereof · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• C08K5/07

  Aldehydes; Ketones · CPC title