Implants and biodegradable tissue markers

Patent metadata

Field	Value
Publication number	US-2022125954-A1
Application number	US-202217571168-A
Country	US
Kind code	A1
Filing date	Jan 7, 2022
Priority date	Dec 15, 2009
Publication date	Apr 28, 2022
Grant date	—

Abstract

Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.

First claim

1 . A method for radiation therapy comprising introducing a hydrogel spacer at a site between a first tissue location and a second tissue location to increase a distance between the first tissue location and the second tissue location, the site being chosen to decrease radiation at the first tissue when the second tissue receives a dose of therapeutic radiation, wherein the hydrogel spacer comprises a polysaccharide and is visible under ultrasound.

2 . The method of claim 1 , wherein the polysaccharide is hyaluronic acid.

3 . The method of claim 1 , wherein the hydrogel spacer comprises an ultrasound contrast agent.

4 . The method of claim 1 , wherein the first tissue location is associated with the rectum and the second tissue location is associated with the prostate gland.

5 . The method of claim 1 , wherein the spacer provides a fiducial marker for administration of the therapeutic radiation.

6 . The method of claim 5 , further comprising visualizing the interface of the fiducial marker and the second tissue.

7 . The method of claim 1 , wherein the hydrogel spacer is echolucent under ultrasound.

8 . The method of claim 1 , further comprising making a radiation plan based on a visualization of the hydrogel spacer, with the hydrogel spacer being in contact with the second tissue.

9 . The method of claim 8 , with the plan having a reduced uncertainty in target definition relative to a radiation plan made without the hydrogel spacer.

10 . The method of claim 1 , wherein the hydrogel spacer, as placed in the tissue, has a volume between 1 and 40 ml.

11 . The method of claim 1 , further comprising visualizing margins of the hydrogel spacer using ultrasound imaging.

12 . The method of claim 1 , further comprising a therapeutic agent in the hydrogel spacer.

13 . A method for radiation therapy comprising introducing a hydrogel spacer at a site between a first tissue location and a second tissue location, the site being chosen to decrease radiation at the first tissue when the second tissue receives a dose of therapeutic radiation, wherein the hydrogel spacer comprises hyaluronic acid and is visible under ultrasound.

14 . The method of claim 13 , herein the first tissue location is associated with the rectum and the second tissue location is associated with the prostate gland.

15 . The method of claim 13 , wherein the hydrogel spacer, as placed in the tissue, has a volume between 1 and 40 ml.

16 . The method of claim 13 , wherein the hydrogel spacer comprises an ultrasound contrast agent.

17 . The method of claim 13 , wherein the spacer provides a fiducial marker for administration of the therapeutic radiation.

18 . The method of claim 13 , wherein the hydrogel spacer is echolucent under ultrasound.

19 . A method for radiation therapy comprising (a) introducing a hydrogel spacer at a site between a first tissue location and a second tissue location, the site being chosen to decrease radiation at the first tissue when the second tissue receives a dose of therapeutic radiation, wherein the hydrogel spacer comprises hyaluronic acid and is visible under ultrasound and (b) visualizing margins of the hydrogel spacer with ultrasound imaging.

20 . The method of claim 19 , wherein the hydrogel spacer is echolucent under ultrasound.

Assignees

• Incept Llc

Inventors

• Campbell Patrick
• Sawhney Amarpreet S

Classifications

• A61L27/50 Primary

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61K49/0442 Primary

  Polymeric X-ray contrast-enhancing agent comprising a halogenated group · CPC title

• A61L27/52

  Hydrogels or hydrocolloids · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title