Apparatus and Method For Delivery of Antimicrobial During a Transdermal Sampling and Delivery Process

Patent metadata

Field	Value
Publication number	US-2022104732-A1
Application number	US-202117553286-A
Country	US
Kind code	A1
Filing date	Dec 16, 2021
Priority date	Aug 3, 2015
Publication date	Apr 7, 2022
Grant date	—

Abstract

A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.

First claim

1 . A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid of a user comprising:
a substrate having thereon
a mechanism for accessing the interstitial fluid of the user having at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for causing a micropore in the user's skin by thermal ablation of at least a portion of the skin's stratum corneum; and
a nanofiber mat loaded with at least one antimicrobial material, wherein the nanofiber mat is disposed on a skin-facing side of the substrate and is arranged on the skin-facing side such that it contacts the user's skin and encircles an opening of the micropore.

2 . The device of claim 1 , wherein the nanofiber mat is generally ring shaped.

3 . The device of claim 1 , wherein the nanofiber mat is loaded with more than one antimicrobial material.

4 . The device of claim 1 , wherein one of the at least one antimicrobial material is LL-37.

5 . The device of claim 1 , wherein the substrate includes thereon multiple individually controllable sites for accessing interstitial fluid of a user, each of the multiple individually controllable sites including:
a mechanism for accessing the interstitial fluid of the user; and a nanofiber mat loaded with at least one antimicrobial material.

6 . The device of claim 5 , wherein each mechanism includes at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion.

7 . The device of claim 6 , wherein each microheating element causes a micropore in the user's skin.

8 . The device of claim 7 , wherein each nanofiber mat is disposed on a skin-facing side of the substrate and is arranged on the skin-facing side such that it contacts the user's skin and encircles an opening of an associated micropore.

9 . The device of claim 5 , wherein each nanofiber mat is loaded with more than one antimicrobial material.

10 . The device of claim 5 , wherein one of the at least one antimicrobial material is LL-37.

11 . A hand-held device for electrochemically monitoring an analyte in interstitial fluid of a user comprising:
a first end configured to contact the skin of the user, the first end including a mechanism for ablating the skin of the user to form a micropore to access interstitial fluid and further including a nanofiber mat formed thereon, the nanofiber mat including at least one antimicrobial material; a cartridge connected to the first end and having disposed therein a plurality of disposable sensing elements for contacting interstitial fluid from the micropore to monitor an analyte therein; a second end connected electrically and mechanically to the cartridge and the first end for facilitating operation of the mechanism for ablating the skin, dispensing of a disposable sensing element and monitoring of the analyte.

12 . The hand-held device of claim 11 , wherein the mechanism for ablating the skin includes at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion located at an open-ended tip of the first end.

13 . The device of claim 11 , wherein the nanofiber mat is arranged on a tip of the first end such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element.

14 . The device of claim 11 , wherein the nanofiber mat is loaded with more than one antimicrobial material.

15 . The device of claim 11 , wherein one of the at least one antimicrobial material is LL-37.

16 . A patch including multiple individually controllable sites for accessing interstitial fluid of a user and monitoring at least one analyte therein, comprising:
a substrate having formed thereon the multiple individually controllable sites each including:
a mechanism for producing a micropore in the user's skin and accessing the interstitial fluid of the user the mechanism having at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for producing the micropore in the user's skin by thermal ablation of at least a portion of the skin's stratum corneum; and
a nanofiber mat loaded with at least one antimicrobial material, wherein the nanofiber mat is disposed on a skin-facing side of the substrate and is arranged on the skin-facing side such that it contacts the user's skin and encircles an opening of the micropore; and
an adhesive disposed on the skin-facing side of the substrate for adhering the patch to the skin of the user.

17 . The device of claim 16 , wherein the nanofiber mat is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element; and further wherein the at least one antimicrobial material is LL-37.

18 . The device of claim 16 , wherein the nanofiber mat is loaded with more than one antimicrobial material.

Assignees

• Univ Georgetown

Inventors

• Paranjape Makarand
• Paranjape Shruti M

Classifications

• A61B5/15134 Primary

  Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids · CPC title

• A61B5/157

  {Devices} characterised by integrated means for measuring characteristics of blood · CPC title

• A61B5/150328

  by aseptic fluid · CPC title

• A61B18/082

  Probes or electrodes therefor · CPC title

• A61B2018/00577

  Ablation · CPC title