Method of facilitating nerve growth

Patent metadata

Field	Value
Publication number	US-2022096711-A1
Application number	US-202117547583-A
Country	US
Kind code	A1
Filing date	Dec 10, 2021
Priority date	Jul 2, 2018
Publication date	Mar 31, 2022
Grant date	—

Abstract

Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth

First claim

What is claimed is:

1 . A method of facilitating nerve growth, the method comprising:
positioning a first nerve end of a first nerve into a form cavity; positioning a second nerve end of a second nerve into the form cavity; introducing an in situ forming media in contact with the first nerve end; introducing the in situ forming media in contact with the second nerve end, the in situ forming media being photoresponsive such that the in situ forming media is configured to transition from a flowable state to a nonflowable state upon photopolymerization of the in situ forming media; and photopolymerizing the in situ forming media to transition the in situ forming media from the flowable state to the nonflowable state.

2 . The method of claim 1 , wherein introducing the in situ forming media in contact with the first nerve end comprises delivering the in situ forming media at a junction between the first nerve and the form cavity.

3 . The method of claim 2 , wherein introducing the in situ forming media in contact with the second nerve end comprises delivering the in situ forming media at a second junction between the second nerve and the form cavity.

4 . The method of claim 1 further comprising:
placing a non-adhesive sterile sheet along the first nerve and the second nerve prior to introducing the in situ forming media; and
removing the non-adhesive sterile sheet after introducing the in situ forming media.

5 . The method of claim 4 , wherein the non-adhesive sterile sheet is configured to physically separate the in situ forming media from a surrounding tissue during photopolymerization.

6 . The method of claim 1 , wherein the form cavity comprises silicone.

7 . The method of claim 1 , wherein the form cavity comprises a nerve wrap.

8 . The method of claim 1 , wherein the form cavity comprises a nerve conduit.

9 . The method of claim 1 , wherein the in situ forming media comprises a color additive configured aid in visual contrast relative to background tissue.

10 . The method of claim 1 , wherein at least one of the first nerve end or the second nerve end comprises a coaptation site.

11 . The method of claim 1 , wherein the in situ forming media comprises PGSA.

12 . The method of claim 1 , wherein the in situ forming media comprises a liquid when in the flowable state.

13 . The method of claim 1 , wherein the form cavity is biodegradable.

14 . The method of claim 1 , wherein the in situ forming media is biodegradable.

15 . The method of claim 1 , wherein introducing the in situ forming media in contact with the first nerve end comprises delivering the in situ forming media circumferentially along the first nerve.

16 . The method of claim 1 , wherein introducing the in situ forming media in contact with the second nerve end comprises delivering the in situ forming media circumferentially along the second nerve.

Assignees

• Tulavi Therapeutics Inc
• Incept Llc

Inventors

• Bright Corinne
• Ren Yong
• Martin Kenneth M
• Khosravi Farhad
• Sawhney Amarpreet S

Classifications

• A61L31/145 Primary

  Hydrogels or hydrocolloids · CPC title

• A61F2240/001

  Designing or manufacturing processes · CPC title

• A61F2210/008

  Phase change materials [PCM], e.g. for storing latent heat · CPC title

• A61L2430/32

  for nerve reconstruction · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title